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Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Bioorganic and Medicinal Chemistry Letters
,130
(January)
Ferroptosis is a regulated form of cell death characterized by lipid peroxidation and excessive reactive oxygen species (ROS) accumulation, which are driven primarily by iron dysregulation. It plays a critical role in ...
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Circulating tumour DNA as a predictor of survival of patients with diffuse large B-cell lymphoma in a daily practice
letter to the editors
open access
vydavatelská verze
2025
,Blackwell
,British Journal of Haematology
,online AoP
(07 September 2025)
Diffuse large B-cell lymphoma (DLBCL) is a relatively well treatable disease with long-term cure rates between 60% and 70% following standard front-line immunochemotherapy R-CHOP (i.e. rituximab, cyclophosphamide, doxorubicin, ...
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Acceptability of meat tax and subsidy removal by meat eaters: insights from five European countries
původní článek
open access
vydavatelská verze
2025
,SPRINGERNATURE
,Agricultural and food economics
,13
(1)
Governments worldwide are exploring policies aimed at promoting healthier and more sustainable dietary choices. This study examines the public acceptability of two promising yet controversial policy interventions: the ...
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TRAF6 Drives Dual Innate Immune Pathways During MPyV Infection: TLR4 and cGAS–STING
abstrakt v elektronické podobě
open access
postprint
2025
,Immunobiology of Pattern Recognition Receptors
A variety of pattern recognition receptors (PRRs) can simultaneously detect pathogens and trigger a broad spectrum of innate immune responses. Recent studies have increasingly highlighted the complex interplay between ...
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The role of snowmelt, glacier melt and rainfall in streamflow dynamics on James Ross Island, Antarctic Peninsula
původní článek
open access
vydavatelská verze
2025
,Copernicus Publ.
,Cryosphere
,19
(7)
The Antarctic Peninsula is experiencing a rapid increase in air temperature, which has a major impact on the entire ecosystem, including the runoff process. Understanding the water balance dynamics in such a fragile and ...
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Citizenship Education Curriculum Making for Troubled Times
původní článek
open access
vydavatelská verze
2025
,Univerzita Karlova, Nakladatelství Karolinum
,Orbis scholae
,18
(3)
The rise of far-right forces in Europe, the increase in the number ofilliberal and autocratic regimes, and influence operations against European democracies call for anew role of citizenship education. While education ...
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The WANDA Reflective Method as a Tool for Improving Teachers’ Well-being
původní článek
open access
vydavatelská verze
2025
,Založba PEF, Pedagoška fakulteta
,Revija za Elementarno Izobraževanje
,18
(Special Issue)
This qualitative research study focuses on teachers' well-being in the context of the WANDA reflective method. The aim was to explore teachers' subjective perceptions of the benefits of WANDA on their well-being. Data were ...
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Multi-region investigation of 'man' as default in attitudes
původní článek
open access
vydavatelská verze
2025
,Public Library of Science
,PLoS One
,20
(6)
Previous research has studied the extent to which men are the default members of social groups in terms of memory, categorization, and stereotyping, but not attitudes which is critical because of attitudes' relationship ...
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Complex temporal dynamics of mental health indicators: A longitudinal network approach perspective
původní článek
open access
vydavatelská verze
2025
,Cambridge University Press
,Psychological Medicine
,55
(Neuveden)
Background Although mental disorders have long been considered complex dynamic systems, our understanding of the mutual interactions and temporal patterns of their symptoms remains limited.Methods In this longitudinal ...
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Registered Replication Report: Study 3 From Trafimow and Hughes (2012)
původní článek
open access
vydavatelská verze
2025
,SAGE Publications
,Advances in Methods and Practices in Psychological Science
,8
(2)
Terror-management theory (TMT) proposes that when people are made aware of their own death, they are more likely to endorse cultural values. TMT is a staple of social psychology, featured prominently in textbooks and the ...
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Moisture governs diesel biodegradation in sand soil – polystyrene microplastic have a negligible impact
původní článek
open access
vydavatelská verze
2025
,Elsevier Science
,Journal of Hazardous Materials
,2025
(498)
Global plastic production has reached 450 million tons annually, yet less than 15 % is recycled, with nearly onethird entering the environment, often as microplastics. This study investigates how microplastics influence ...
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UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of Hepatitis B virus maturation and egress
původní článek
open access
vydavatelská verze
2025
,American Society for Biochemistry and Molecular Biology
,Journal of Biological Chemistry
,301
(11)
A critical step in Hepatitis B virus (HBV) maturation and egress is the ubiquitination of the capsid/core protein (HBc), which enables its recognition by the endosomal sorting complex required for transport (ESCRT) machinery ...
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Glial Activation Enhances Spinal TRPV1 Receptor Sensitivity in a Paclitaxel Model of Neuropathic Pain
původní článek
embargo
vydavatelská verze
2025
,Institute of Physiology, Academy of Sciences of the Czech Republic
,Physiological Research
,74
(3)
Paclitaxel (PTX), a commonly used chemotherapeutic, frequently leads to chemotherapy-induced peripheral neuropathy (CIPN), characterized by persistent pain and neuronal hypersensitivity. While its effects on peripheral ...
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Dissecting Isoform-Specific Functions of PML in Innate Antiviral Immunity Using a Murine Polyomavirus Model
abstrakt v elektronické podobě
open access
postprint
2025
,UNIL
,Immunobiology of Pattern Recognition Receptors
The promyelocytic leukemia (PML/TRIM19) protein, a member of theTRIM family, serves as the main scaffold component of PML nuclearbodies (PML NBs), dynamic, multiprotein organelles involved in diversecellular processes ...
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Long-Term Impact of Urban Areas on Meteorological Conditions Over Central Europe
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Annals of the New York Academy of Sciences
,Neuveden
(September 2025)
The impact of urban areas on relevant meteorological variables, especially on temperature and wind speed, is well-known, and several studies have evaluated this effect. However, fewer of them have focused on the effect of ...
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Medicalizing aesthetics or beautifying illness? Exploring the absence of diagnosis and the centrality of patient autonomy in dermatology
původní článek
open access
vydavatelská verze
2025
,ELSEVIER
,SSM. Qualitative research in health
,7
(June 2025)
The moment of diagnosis is often regarded as a cornerstone of clinical practice and patienthood. It has mainly been viewed as preceding, and hence profoundly shaping, patients' constructions of health and illness. However, ...
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Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies
původní článek
open access
vydavatelská verze
2025
,ACS Publications
,Journal of Medicinal Chemistry
,XXX
(XXX)
Tuberculosis (TB) imposes a major global health challenge, aggravated by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. Scaffold hopping, a medicinal chemistry approach that modifies the molecular ...
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Changes of abdominal wall tension across various resistance exercises during maximal and submaximal loads in healthy adults: a cross-sectional study
původní článek
open access
vydavatelská verze
2025
,BioMed Central
,BMC Sports Science, Medicine and Rehabilitation
,17
(1)
INTRODUCTION: Resistance exercises are effective for maintaining health and activating stabilizing muscles, as they trigger abdominal wall tension responses. This study compared the effects of multi-joint and single-joint, ...
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Preoccupied and Fearful-Avoidant Attachment Styles May Mediate the Relationship Between Poor Parental Relationship Quality and Sexual Interests in Violence
původní článek
open access
vydavatelská verze
2025
,Archives of Sexual Behavior
,54
(7)
Research suggests that adverse rearing conditions such as poor-quality relations with one's parents are associated with a range of potentially problematic sexual behaviors and interests. Less is known, however, about the ...
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A Liquid State of Exception: The Shifting Boundaries of Violence in the Czech Lands, 1944– 1945
původní článek
embargo
preprint
2025
,Taylor & Francis Group
,International History Review
,Neuveden
(neuvedeno)
This article explores the persistence and transformation of violence in the Czech lands during the transition from Nazi occupation to post-war retribution, with a focus on role reversals and shifting power dynamics. Through ...
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