2. lékařská fakulta
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Poslední příspěvky
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Using patterns of shared taxa to infer bacterial dispersal in human living environment in urban and rural areas
původní článek
open access
vydavatelská verze
2024
,Applied and Environmental Microbiology
,E-PUB
Contact with environmental microbial communities primes the human immune system. Factors determining the distribution of microorganisms, such as dispersal, are thus important for human health. Here, we used the relative ...
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Educational inequalities in cervical cancer screening participation in 24 European countries
původní článek
open access
vydavatelská verze
2024
,Public Health
,233
(August)
OBJECTIVES: Cervical cancer screening (CCS) is an important public health measure for early detection of cervical cancer and prevents a large proportion of cervical cancer deaths. However, participation in CCS is relatively ...
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Correlation of genotype, phenotype and mitochondrial metabolism of patients with Friedreich's ataxia with the aim of implementing innovative therapies
poster
omezený přístup
postprint
2022
Title: Presentation of a cohort of 40 Czech and Slovak patients with Friedreich's ataxia with the aim of introducing innovative therapiesBackground and objectives: Friedreich's ataxia (FA) is an autosomal recessive inherited ...
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Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(1)
A resilient immune system is characterized by its capacity to respond appropriately to challenges, such as infections, and it is crucial in vaccine response. Here we report a paired randomized intervention-control trial ...
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Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics
původní článek
open access
vydavatelská verze
2024
,Journal of Clinical Virology
,173
(August)
Metagenomics is gradually being implemented for diagnosing infectious diseases. However, in-depth protocol comparisons for viral detection have been limited to individual sets of experimental workflows and laboratories. ...
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High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas
původní článek
open access
vydavatelská verze
2023
,Frontiers in Endocrinology
,14
(December)
INTRODUCTION: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors, which are mostly benign in nature. Amongst all genes, Succinate Dehydrogenase Subunit D (SDHD) is the most commonly mutated in familial ...
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Constitutional and acquired genetic variants in ARID5B in pediatric B-cell precursor acute lymphoblastic leukemia
původní článek
open access
vydavatelská verze
2024
,Genes, Chromosomes & Cancer
,63
(5)
Constitutional polymorphisms in ARID5B are associated with an increased risk of developing high hyperdiploid (HeH; 51-67 chromosomes) pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL). Here, we investigated ...
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The gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" category
letter to the editors
open access
vydavatelská verze
2024
,Leukemia
,38
(7)
Detection of measurable residual disease (MRD) in hematological malignancies is crucial for prognostication and treatment decisions. Real-time quantitative PCR (RQ-PCR), which targets immunoglobulin (IG) and T-cell receptor ...
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Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia
letter to the editors
open access
vydavatelská verze
2024
,Haematologica
,109
(6)
We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients <10 years ...
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Clinical and molecular study of radiation-induced gliomas
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(1)
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG ...
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Pediatric basilar invagination: Unveiling a rare complication of inflammatory bowel disease unclassified
kazuistika
open access
vydavatelská verze
2024
,PM and R
,16
(7)
This case report details the presentation of an 8-year-old boy with atlantoaxial rotatory dislocation (AARD) and basilar invagination (BI), an exceedingly rare complication of inflammatory bowel disease unclassified (IBDU). ...
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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data
původní článek
open access
vydavatelská verze
2024
,Annals of Nutrition & Metabolism
,80
(3)
INTRODUCTION: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the ...
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Learning Support Systems: A Practical Guide to E-learning at CU
necertifikovaná metodika
open access
draft
2024
,Praha
,Univerzita Karlova, Nakladatelství Karolinum
This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...
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Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
původní článek
open access
vydavatelská verze
2024
,Leukemia
,38
(1)
Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treatment and for early detection of imminent relapse. In childhood AML, MRD is typically evaluated using ...
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
původní článek
open access
vydavatelská verze
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
původní článek
open access
vydavatelská verze
2022
,Acta Neuropathologica Communications
,10
(1)
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular ...
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Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model
původní článek
open access
vydavatelská verze
2024
,Hypertension Research
,E-PUB
(E-PUB)
Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable ...
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The differences in virome from distinct anatomical locations in psoriasis patients
abstrakt v elektronické podobě
open access
postprint
2024
,Praha
,Česká zemědělská univerzita
,CzechoSlovak Virology Conference 2024 : Book of Abstracts
,1
(1)
Psoriasis, a chronic autoimmune inflammatory disorder affecting 2-3% of the global population,exhibits a multifactorial aetiology with a significant genetic component and triggers such as trauma orinfection.
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Examining the Correlation Between Neurofilament Levels and Clinical Features in a Friedreich Ataxia Cohort from the Czech Republic
přednáška
omezený přístup
preprint
2023
Objective: Friedreich's ataxia (FA) is the most common autosomal recessive hereditary ataxia caused by a mutation in the FXNgene characterized by ataxia, dorsal root syndrome, scoliosis, cardiomyopathy, and other symptoms. ...
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Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status
původní článek
embargo
vydavatelská verze
2023
,Frontiers in Psychiatry [online]
,14
(March)
INTRODUCTION: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between ...
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