3. lékařská fakulta
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Poslední příspěvky
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
původní článek
open access
vydavatelská verze
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma
původní článek
open access
vydavatelská verze
2024
,iScience
,27
(2)
Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most ...
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Nutritional practices and experiences of people on vegan diet with healthcare system: a qualitative study
přehledový článek
open access
vydavatelská verze
2023
,Central European Journal of Public Health
,31
(3)
OBJECTIVES: The growing popularity of diets that restrict the consumption of animal-based foods is an important new challenge for the public healthcare system in Czechia. While the environmental and health-related benefits ...
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Atrial fibrillation therapy and stroke prevention in hemodialysis patients
přehledový článek
open access
vydavatelská verze
2023
,Kardiologia Polska
,81
(12)
The prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), especially on hemodialysis (HD) is higher compared to the general population without CKD and reaches ~20%. The risk of ischemic ...
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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
přehledový článek
embargo
vydavatelská verze
2023
,Frontiers in Endocrinology
,14
(April)
Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...
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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
původní článek
embargo
vydavatelská verze
2023
,Hypertension Research
,46
(9)
The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...
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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
původní článek
open access
vydavatelská verze
2023
,Genes
,14
(2)
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant ...
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Resynchronization for shifting conduction patterns - When a coronary sinus lead is not enough
kazuistika
open access
vydavatelská verze
2023
,Indian Pacing and Electrophysiology Journal
,23
(6)
A 60-year-old patient with heart failure (NYHA II) due to non-ischemic cardiomyopathy with a left ventricular end-diastolic diameter (LVEDD) of 73 mm and left ventricular ejection fraction (LVEF) 20% presented with ...
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Left ventricular septal pacing - can we trust the ECG?
kazuistika
open access
vydavatelská verze
2023
,Indian Pacing and Electrophysiology Journal
,23
(6)
In contrast to left bundle branch pacing, the criteria for left ventricular septal pacing (LVSP) were never validated. LVSP is usually defined as deep septal deployment of the pacing lead with a pseudo-right bundle branch ...
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Prediction of post-operative atrial fibrillation in patients after cardiac surgery using heart rate variability
původní článek
open access
vydavatelská verze
2023
,BMC Cardiovascular Disorders
,23
(June)
PURPOSE: Post-operative atrial fibrillation (PoAF) occurs in ~ 30% of patients after cardiac surgery. The etiology of PoAF is complex, but a disbalance in autonomic systems plays an important role. The goal of this study ...
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Severe COVID-19 associated hyperglycemia is caused by beta cell dysfunction: a prospective cohort study
původní článek
open access
vydavatelská verze
2023
,Nutrition & Diabetes
,13
(July)
BACKGROUND: COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms contributing to the development of hyperglycemia are still unclear. We ...
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A randomized comparison of His bundle pacing versus right ventricular pacing: Effect on left ventricular function and biomarkers of collagen metabolism
původní článek
open access
vydavatelská verze
2023
,Kardiologia Polska
,81
(5)
BACKGROUND: Right ventricular pacing (RVP) can result in pacing-induced cardiomyopathy (PICM). It is unknown whether specific biomarkers reflect differences between His bundle pacing (HBP) and RVP and predict a decrease ...
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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
původní článek
open access
vydavatelská verze
2023
,Journal of Cardiovascular Electrophysiology
,34
(9)
INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...
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Prevalence of iodine deficiency among vegan compared to vegetarian and omnivore children in the Czech Republic: cross-sectional study
původní článek
open access
vydavatelská verze
2023
,European Journal of Clinical Nutrition
,77
(11)
BACKGROUND: The intake and homeostasis of iodine, an essential micronutrient that plays a vital role in thyroid physiology, is of particular concern with the increasing popularity of vegetarian (VG) and vegan (VN) diets. ...
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Acute ischaemic stroke: recent advances in reperfusion treatment
přehledový článek
open access
vydavatelská verze
2023
,European Heart Journal
,44
(14)
During the last 5-7 years, tremendous progress was achieved in the reperfusion treatment of acute ischaemic stroke during its first few hours from symptom onset. This review summarizes the latest evidence from randomized ...
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Targets for pollutants in rat and human pancreatic beta-cells: The effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins
původní článek
open access
vydavatelská verze
2023
,Environmental Toxicology and Pharmacology
,104
(November)
Decades after most countries banned hexachlorocyclohexane, HCH isomers still pollute the environment. Many studies described HCH as a pro-diabetic factor; nevertheless, the effect of HCH isomers on pancreatic beta-cells ...
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Muscle Lipid Oxidation Is Not Affected by Obstructive Sleep Apnea in Diabetes and Healthy Subjects
původní článek
open access
vydavatelská verze
2023
,International Journal of Molecular Sciences
,24
(6)
The molecular mechanisms linking obstructive sleep apnea (OSA) with type 2 diabetes mellitus (T2DM) remain unclear. This study investigated the effect of OSA on skeletal muscle lipid oxidation in nondiabetic controls and ...
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Is it a true left bundle branch block or not?
letter to the editors
open access
vydavatelská verze
2023
,Journal of Interventional Cardiac Electrophysiology
,66
(6)
Among patients with wide QRS complexes of nonRBBB morphologies on ECG, there are those with preserved left septal Purkinje activation, i.e., intraventricular conduction delay (IVCD). Unfortunately, twelve lead ECGs do not ...
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Left ventricular resynchronization with left bundle branch area pacing: does the type of capture matter?
editorial
open access
vydavatelská verze
2023
,Europace
,25
(6)
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) has been a mainstream treatment in heart failure patients with wide QRS complexes for two decades. In recent years, left bundle branch pacing (LBBP) ...
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Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing
původní článek
open access
vydavatelská verze
2023
,Frontiers in Cardiovascular Medicine
,10
(March)
BACKGROUND: Left bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal pacing with ...
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