Farmaceutická fakulta v Hradci Králové
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Poslední příspěvky
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Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout ...
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Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure-Activity Relationship
původní článek
open access
vydavatelská verze
2025
,Blackwell
,Influenza and Other Respiratory Viruses
,19
(10)
Background: Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against ...
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New antimycobacterial sulfonamide-based ureas
jiný příspěvek v konferenčním sborníku
open access
postprint
2025
,Praha
,Programme Book of Abstracts
Certain antimicrobial properties of sulfonamide-type compounds have been described many times.1 We focused our attention on a drug containing the aforementioned sulfonamide group, which originally had no antimicrobial ...
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SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF ACETOPHENONE-HYDRAZONE DERIVATIVES AGAINST RESISTANT MYCOBACTERIA
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,BOOK OF ABSTRACTS
According to the WHO, microbial resistance is among the most urgent global threats with serious health and economic consequences. In 2024, rifampicin-resistant Mycobacterium tuberculosis (Mtb), which is currently one of ...
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INVESTIGATION OF SULFONAMIDES AND THEIR ANALOGUES AS ANTIFUNGAL AGENTS
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,Book of abstracts
The rising incidence of fungal infections, together with increasing resistance to available antifungal drugs, represents a growing healthcare concern and underscores an urgent need for novel antifungal therapies with ...
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INVESTIGATION OF ISOXAZOLE-1,3,4-OXADIAZOLE HYBRIDS AS ANTIMYCOBACTERIAL AGENTS - A PILOT STUDY
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,Book of abstracts
Given the rising number of cases of both latent and drug-resistant tuberculosis, there is an urgent need for thedevelopment of novel, potent compounds capable of combating this global health threat1. In medicinalchemistry, ...
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Modulating Antimicrobial Efficacy Through Hybrid Compounds: Novel Linkers and Scaffold Switching from Isoniazid to 3,5-Dinitrobenzohydrazide
jiný příspěvek v konferenčním sborníku
open access
aktualizovaná vydavatelská verze
2025
,Praha
,Book of abstracts of the 12 th International Conference on Chemical Technology
Tuberculosis and non-tuberculous mycobacterial infections present significant treatment challenges due to rising drug resistance. Building on our previous success with (E)-2-(2-isonicotinoylhydrazineylidene)-N-phenylpropanamides,1 ...
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Nové látky a nové přístupy v terapii herpetických virů
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Hradec Králové
,SBORNÍK ABSTRAKT XXVII. HRADECKÉ VIROLOGICKÉ DNY Celostátní konference virologů
Infekce způsobené herpetickými viry (HSV-1, HSV-2, VZV, CMV, EBV aj.) stále představujívýznamný zdravotnický problém. Dosavadní terapie je založena zejména na nukleosidových/nukleotidových analozích (acyklovir, ganciklovir ...
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Repurposing sulfonamidů jako antifungálních léčiv aneb Starého psa novým kouskům naučíš
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,SBORNÍK ABSTRAKTŮ Konference 19. a 20. listopadu 2025
Narůstající rezistence mikroorganismů představuje závažnou hrozbu pro veřejné zdraví, což vytváří urgentní potřebu nových léčiv. Systémové mykózy jsou však v porovnání s bakteriálními infekcemi stále přehlíženy, ačkoli ...
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Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis
původní článek
open access
vydavatelská verze
2025
,Harcourt
,Placenta
,172
(December)
Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...
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Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...
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Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit
původní článek
open access
vydavatelská verze
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,192
(November)
Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...
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Novel Quinazolinones Active against Multidrug-Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin-Binding Protein 1A as a Potential Target
původní článek
open access
vydavatelská verze
2025
,Wiley-VCH-Verl.
,ChemMedChem
,20
(13)
Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone-based compounds and predicts their potential ...
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Antimicrobial and Antiproliferative Properties of 2-Phenyl-N-(Pyridin-2-yl)acetamides
původní článek
open access
vydavatelská verze
2025
,Blackwell Munksgaard
,Chemical Biology and Drug Design
,105
(1)
Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic. Tuberculosis (TB) is an old infectious disease for which ...
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Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages
původní článek
open access
vydavatelská verze
2025
,Wiley-VCH-Verl.
,Macromolecular Bioscience
,25
(2)
Glucocorticoids are potent anti-inflammatory drugs, although their use is associated with severe side effects. Loading glucocorticoids into suitable nanocarriers can significantly reduce these undesirable effects. Macrophages ...
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Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives
původní článek
open access
vydavatelská verze
2025
,Wiley-VCH-Verl.
,ChemMedChem
,20
(18)
A series of 33 (E)-N'-benzylidenepyrazine-2-carbohydrazides and their derivatives were synthesized and tested for biological activity. Benzylidene derivatives with 2-OH substitution on the phenyl ring (18: R = 2-OH, 21: R ...
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The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach
původní článek
open access
vydavatelská verze
2025
,Wiley-VCH-Verl.
,Archiv der Pharmazie
,358
(1)
The Takeda G protein-coupled receptor 5 (TGR5), also known as GPBAR1 (G protein-coupled bile acid receptor), is a membrane-type bile acid receptor that regulates blood glucose levels and energy expenditure. These essential ...
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A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant acinetobacter baumannii
původní článek
open access
vydavatelská verze
2025
,Springer
,Medical Microbiology and Immunology
,214
(1)
This comprehensive study provides insight into the antibacterial action of a recently published 2-chloro-N-(oxazol-2-yl)isonicotinamide (AB15), intending to assess its potential as a candidate adjuvant molecule to support ...
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Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies
přehledový článek
open access
vydavatelská verze
2025
,ACS Publications
,Journal of Medicinal Chemistry
,68
(20)
Tuberculosis (TB) imposes a major global health challenge, aggravated by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. Scaffold hopping, a medicinal chemistry approach that modifies the molecular ...
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Advanced polymer nanofibers for the online extraction coupled with liquid chromatography for the determination of emerging fluorinated contaminants in surface water
původní článek
open access
vydavatelská verze
2026
,Elsevier B.V.
,Talanta
,298
(February 2026)
Advanced polyacrylonitrile, polypropylene, polyhydroxybutyrate, polycaprolactone, and poly(vinylidene difluoride) nanofibers, including composite materials containing carbon nanoparticle additives, combined micro/nanofibers, ...
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