Lékařská fakulta v Hradci Králové

 

Poslední příspěvky

  • Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway 

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    Karabanovich, Galina

    ;

    Fabiánová, Viktória

    ;

    Vocat, Anthony

    ;

    Dušek, Jan

    ;

    Valášková, Lenka

    ;

    Stolaříková, Jiřina

    ;

    Kitson, Russell R. A.

    ;

    Pávek, Petr

    ;

    Vávrová, Kateřina

    ;

    Djaout, Kamel

    ;

    Mikušová, Katarína

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    Baulard, Alain R.

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    Cole, Stewart T.

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    Korduláková, Jana

    ;

    Roh, Jaroslav

    2024

    ,

    Journal of Medicinal Chemistry

    ,

    XXXX

    (XXX)

    3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and nonreplicating mycobacteria and favorable cytotoxicity and genotoxicity ...

  • Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial 

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    Branny, Marian

    ;

    Osmančík, Pavel

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    Kala, Petr

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    Poloczek, Martin

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    Heřman, Dalibor

    ;

    Neužil, Petr

    ;

    Hála, Pavel

    ;

    Táborský, Miloš

    ;

    Šťásek, Josef

    ;

    Haman, Luděk

    ;

    Chovančík, Jan

    ;

    Červinka, Pavel

    ;

    Holý, Jiří

    ;

    Kovárník, Tomáš

    ;

    Zemánek, David

    ;

    Havránek, Štěpán

    ;

    Vančura, Vlastimil

    ;

    Peichl, Petr

    ;

    Toušek, Petr

    ;

    Hozman, Marek

    ;

    Lekešová, Veronika

    ;

    Jarkovský, Jiří

    ;

    Nováčková, Martina

    ;

    Benešová, Klára

    ;

    Widimský, Petr

    ;

    Reddy, Vivek Y

    2023

    ,

    Journal of Cardiovascular Electrophysiology

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    34

    (9)

    INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...

  • Is it a true left bundle branch block or not? 

    letter to the editors

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    Čurila, Karol

    ;

    Jurák, Pavel

    ;

    Chelu, Mihail G.

    ;

    Upadhyay, Gaurav

    ;

    Sedláček, Kamil

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    Osmančík, Pavel

    2023

    ,

    Journal of Interventional Cardiac Electrophysiology

    ,

    66

    (6)

    Among patients with wide QRS complexes of nonRBBB morphologies on ECG, there are those with preserved left septal Purkinje activation, i.e., intraventricular conduction delay (IVCD). Unfortunately, twelve lead ECGs do not ...

  • Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer 

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    Blažek, Jiří

    ;

    Hošek, Petr

    ;

    Hrabcova, Karolina

    ;

    Bratova, Monika

    ;

    Kultan, Juraj

    ;

    Hrnčiarik, Michal

    ;

    Černovská, Markéta

    ;

    Zemanová, Petra

    ;

    Krejčí, Jana

    ;

    Koubková, Leona

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    Stastny, Marek

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    Svatoň, Martin

    2023

    ,

    In Vivo

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    37

    (5)

    BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...

  • The dynamics of telomere length in primary and metastatic colorectal cancer lesions 

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    Kroupa, Michal

    ;

    Kubeček, Ondřej

    ;

    Tomášová, Kristýna

    ;

    Hanak, Petr

    ;

    Krůpová, Markéta

    ;

    Červená, Klára

    ;

    Šišková, Anna

    ;

    Rosendorf, Jáchym

    ;

    Hošek, Petr

    ;

    Vodičková, Ludmila

    ;

    Vodička, Pavel

    ;

    Liška, Václav

    ;

    John, Stanislav

    ;

    Vymetálková, Veronika

    ;

    Petera, Jiří

    2023

    ,

    Scientific Reports

    ,

    13

    (1)

    Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...

  • MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes 

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    Sojka, Ladislav

    ;

    Opattová, Alena

    ;

    Bartu, Linda

    ;

    Horák, Josef

    ;

    Korenková, Vlasta

    ;

    Novosadova, Vendula

    ;

    Křížková, Věra

    ;

    Brůha, Jan

    ;

    Liška, Václav

    ;

    Schneiderová, Michaela

    ;

    Kubeček, Ondřej

    ;

    Vodičková, Ludmila

    ;

    Urbanova, Marketa

    ;

    Simsa, Jaromir

    ;

    Vodička, Pavel

    ;

    Vymetálková, Veronika

    2023

    ,

    Oncology Letters

    ,

    25

    (2)

    MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...

  • COVID-19 Vaccination among Czech Dentists 

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    Schmidt, Jan

    ;

    Peřina, Vojtěch

    ;

    Treglerová, Jana

    ;

    Pilbauerová, Nela

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    Suchánek, Jakub

    ;

    Šmucler, Roman

    2022

    ,

    Vaccines

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    10

    (3)

    This work describes and evaluates vaccination against COVID-19 among members of the Czech Dental Chamber during the pre-booster vaccination phase. A cross-sectional online survey was conducted between 23 June and 4 September ...

  • Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome 

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    Fišerová, Ivana

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    Trinh, Minh Duc

    ;

    Elkalaf, Moustafa

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    Vacek, Lukáš

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    Heide, Marek

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    Martínková, Stanislava

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    Bechyňská, Kamila

    ;

    Kosek, Vít

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    Hajšlová, Jana

    ;

    Fišer, Ondřej

    ;

    Toušek, Petr

    ;

    Polák, Jan

    2022

    ,

    Frontiers in Cardiovascular Medicine [online]

    ,

    9

    (August)

    Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. ...

  • Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register 

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    Cinek, Ondřej

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    Slavenko, Matvei

    ;

    Pomahačová, Renata

    ;

    Venháčová, Petra

    ;

    Petruželková, Lenka

    ;

    Škvor, Jaroslav

    ;

    Neumann, David

    ;

    Konečná, Petra

    ;

    Vosáhlo, Jan

    ;

    Kocourková, Kamila

    ;

    Strnadel, Jiří

    ;

    Průhová, Štěpánka

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    Šumník, Zdeněk

    2022

    ,

    Pediatric Diabetes

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    23

    (7)

    OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...

  • Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk 

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    Šimják, Patrik

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    Petr, Tomáš

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    Kaslová, Barbora

    ;

    Fejfar, Tomáš

    ;

    Hůlek, Petr

    ;

    Pařízek, Antonín

    ;

    Vítek, Libor

    2022

    ,

    Scientific Reports

    ,

    12

    (1)

    In the literature on the safety of ursodeoxycholic acid (UDCA) during breastfeeding, insufficient data has been reported to date. Thus, the aim of our study was to analyze bile acid (BA) concentrations in breast milk in a ...