Lékařská fakulta v Plzni
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Poslední příspěvky
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EVIDENCE BASED SELECTION OF HYPERPARAMETERS FOR EPITHELIAL SEGMENTATION IN WHOLE SLIDE IMMUNOHISTOCHEMISTRY IMAGES: FROM NORMAL MUCOSA TO COLORECTAL CANCER
původní článek
open access
preprint
2026
Background. Accurate delineation of the epithelial compartment is a critical prerequisite for reproducible quantitative analysis in digital pathology, particularly in colorectal cancer (CRC) where malignant glands determine ...
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Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
původní článek
open access
vydavatelská verze
2026
,Springer
,Cancer Immunology, Immunotherapy
,75
(1)
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study
původní článek
open access
vydavatelská verze
2026
,Springer-Verlag France
,Hernia
,30
(1)
PURPOSE: Incisional hernia is a common postoperative complication following abdominal surgery. Despite the use of synthetic meshes, recurrence rates remain high. This study aimed to develop and evaluate a biodegradable, ...
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Mutational landscape of lung adenocarcinoma in Czechia
původní článek
open access
vydavatelská verze
2026
,Elsevier Inc.
,Cancer Treatment and Research Communications
,46
Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...
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Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
vydavatelská verze
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
původní článek
open access
preprint
2026
,Springer Nature
,Scientific Reports
,16
(1)
The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...
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Second Primary Lung Cancer Associated With Family History of Lung Cancer
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Cancer Medicine
,14
(23)
BACKGROUND: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of ...
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Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
přehledový článek
open access
vydavatelská verze
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
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Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, ...
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Familial risks in 317,000 prostate cancer patients in relation to metastases and survival guiding diagnostics
původní článek
open access
preprint
2025
Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from ...
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Circulation of Anaplasma phagocytophilum among invasive and native carnivore species living in sympatry in Poland
původní článek
open access
vydavatelská verze
2023
,BMC
,Parasites & Vectors
,16
(1)
Background Anaplasma phagocytophilum is characterized by a worldwide distribution and distinguished from other Anaplasmataceae by the broadest range of mammalian hosts and high genetic diversity. The role carnivores play ...
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Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic
původní článek
open access
vydavatelská verze
2026
,ASM Press
,Microbiology Spectrum
,14
(1)
A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...
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VAST INCREASE IN SECOND PRIMARY LUNG CANCERS IN SWEDEN
původní článek
open access
preprint
2025
Background: We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden.Methods: Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 SPLCs.Results: The incidence ...
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Spatial Patterns and Prognostic Relevance of CD1a Immature and CD208 Mature Dendritic Cells in Colorectal Cancer From Tumour-adjacent Mucosa to Liver
původní článek
open access
preprint
2026
,Springer
,Cancer Immunology, Immunotherapy
,75
(1)
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
-
Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
přehledový článek
open access
preprint
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
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Biomarkers, Omics and Artificial Intelligence for Early Detection of Pancreatic Cancer
původní článek
open access
vydavatelská verze
2025
,Academic Press
,Seminars in Cancer Biology
,111
(June)
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in its late stages when treatment options are limited. Unlike other common cancers, there are no population-wide screening programmes for PDAC. Thus, early ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
postprint
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Relationship between MASLD and women's health: A review
přehledový článek
open access
vydavatelská verze
2025
,SAGE Publications Ltd
,Women's Health
,21
(October)
Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly non-alcoholic fatty liver disease, NAFLD) is a common chronic liver disease strongly linked to obesity, metabolic syndrome (MetS), and type 2 diabetes. ...
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Therapeutic pancreatic cancer biomarkers and pharmacogenetics
přehledový článek
open access
vydavatelská verze
2025
,Academic Press
,Seminars in Cancer Biology
,116
(November)
FOLFIRINOX and gemcitabine plus nab-paclitaxel represent the most effective chemotherapy regimens for metastatic pancreatic cancer patients nowadays, but the median overall survival remains less than one year. Pharmacogenomics ...
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