Lékařská fakulta v Plzni
Procházet dle
Poslední příspěvky
-
Second Primary Lung Cancer Associated With Family History of Lung Cancer
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Cancer Medicine
,14
(23)
BACKGROUND: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of ...
-
Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
přehledový článek
open access
vydavatelská verze
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
-
Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, ...
-
Familial risks in 317,000 prostate cancer patients in relation to metastases and survival guiding diagnostics
původní článek
open access
preprint
2025
Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from ...
-
Circulation of Anaplasma phagocytophilum among invasive and native carnivore species living in sympatry in Poland
původní článek
open access
vydavatelská verze
2023
,BMC
,Parasites & Vectors
,16
(1)
Background Anaplasma phagocytophilum is characterized by a worldwide distribution and distinguished from other Anaplasmataceae by the broadest range of mammalian hosts and high genetic diversity. The role carnivores play ...
-
Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic
původní článek
open access
postprint
2025
,ASM Press
,Microbiology Spectrum
A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...
-
VAST INCREASE IN SECOND PRIMARY LUNG CANCERS IN SWEDEN
původní článek
open access
preprint
2025
Background: We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden.Methods: Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 SPLCs.Results: The incidence ...
-
Spatial Patterns and Prognostic Relevance of CD1aImmature and CD208 Mature Dendritic Cells inColorectal Cancer From Tumour-adjacent Mucosato Liver Metastases
původní článek
open access
preprint
2025
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
-
Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
přehledový článek
open access
preprint
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
-
Biomarkers, Omics and Artificial Intelligence for Early Detection of Pancreatic Cancer
původní článek
open access
vydavatelská verze
2025
,Academic Press
,Seminars in Cancer Biology
,111
(June)
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in its late stages when treatment options are limited. Unlike other common cancers, there are no population-wide screening programmes for PDAC. Thus, early ...
-
Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
postprint
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
-
Relationship between MASLD and women's health: A review
přehledový článek
open access
vydavatelská verze
2025
,SAGE Publications Ltd
,Women's Health
,21
(October)
Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly non-alcoholic fatty liver disease, NAFLD) is a common chronic liver disease strongly linked to obesity, metabolic syndrome (MetS), and type 2 diabetes. ...
-
Therapeutic pancreatic cancer biomarkers and pharmacogenetics
přehledový článek
open access
vydavatelská verze
2025
,Academic Press
,Seminars in Cancer Biology
,116
(November)
FOLFIRINOX and gemcitabine plus nab-paclitaxel represent the most effective chemotherapy regimens for metastatic pancreatic cancer patients nowadays, but the median overall survival remains less than one year. Pharmacogenomics ...
-
Mass spectrometric profiling of microbial polysaccharides using laser desorption/ionization – time-of-flight (LDI-TOF) and liquid chromatography-mass spectrometry (LC-MS): a novel method for structural fingerprinting and derivatization
původní článek
open access
vydavatelská verze
2025
,Frontiers Media S.A.
,Frontiers in Cellular and Infection Microbiology
,15
(October)
Introduction: Over the last two decades, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been introduced into the routine diagnostic practice of microbiological laboratories ...
-
Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
původní článek
open access
vydavatelská verze
2025
,Nature Medicine
,31
(7)
Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...
-
One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Cancer Medicine
,14
(18)
OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...
-
Sex specific familial risk in lung cancer through changing histologies in Sweden
původní článek
open access
vydavatelská verze
2025
,Wiley-Liss
,International Journal of Cancer
,157
(5)
Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in ...
-
Familial risks and incidence rates for childhood nervous system tumors in Sweden
původní článek
open access
vydavatelská verze
2025
,Elsevier Ltd.
,EJC Paediatric Oncology
,6
(December)
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide ...
-
Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase?
původní článek
open access
vydavatelská verze
2025
,American Society for Microbiology
,mSystems
,10
(9)
Wolbachia pipientis is an obligate intracellular bacterium, associated with several arthropods and filarial nematodes. Wolbachia establishes a variety of symbiotic relationships with its hosts, with consequent genomic ...
-
Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
Infections caused by invasive intracellular bacteria pose major therapeutic challenges due to pathogen survival and growth inside of host cells as well as the low intracellular accessibility for conventional antibiotics. ...
RSS 1.0