Lékařská fakulta v Plzni
Procházet dle
Poslední příspěvky
-
The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
původní článek
open access
vydavatelská verze
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
-
Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV
původní článek
open access
vydavatelská verze
2026
,Baishideng Publishing Group Inc
,World Journal of Gastroenterology
,32
(10)
BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic trajectories ...
-
Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
původní článek
open access
vydavatelská verze
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
-
Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(2)
Basal cell adenoma (BCA) is a benign salivary neoplasm that exhibits a divergent spectrum of growth patterns, including cribriform, tubular, trabecular, membranous, and solid. A subset of BCAs is characterized by the ...
-
Sclerosing mucoepidermoid carcinoma of salivary glands
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,487
(1)
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory ...
-
Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity
původní článek
open access
vydavatelská verze
2025
,Blackwell Science
,Histopathology
,86
(4)
AIMS: Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal ...
-
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation
původní článek
open access
vydavatelská verze
2025
,Lippincott-Raven Publishers
,American Journal of Surgical Pathology
,49
(3)
Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB, or less commonly MYBL1::NFIB. Sinonasal ...
-
Sinonasal adenoid cystic carcinomas accompanied by seromucinous hamartoma and/or atypical sinonasal glands arising from seromucinous hamartoma: insight into their histogenesis
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,486
(6)
The pathology of reactive, dysplastic, and neoplastic sinonasal seromucinous glands is complex, and their contribution to tumorigenesis of sinonasal carcinomas remains controversial. In our practice, we have observed the ...
-
Oncocytic Tumors in the Salivary Gland: A Tri-Focal Review - Integrated Cytopathological, Pathological, and Molecular Features
přehledový článek
open access
vydavatelská verze
2025
,S. Karger
,Acta Cytologica
,69
(5)
Background: Primary oncocytic salivary gland tumors and oncocytic subtypes of traditionally non-oncocytic salivary gland neoplasms are occasionally encountered in fine needle aspiration specimens, biopsies, and resections. ...
-
Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre
původní článek
open access
vydavatelská verze
2026
,Frontiers Media SA
,Frontiers in Veterinary Science
,13
(January)
Introduction Antimicrobial resistance (AMR) represents a growing One Health challenge at the human-animal-environment interface. Wildlife rescue centres may represent potential, underrecognized settings where resistant ...
-
Comparative analysis of telomere length in peripheral blood of breast cancer BRCA1 mutation carriers and non-carriers
původní článek
open access
vydavatelská verze
2026
,Springer
,Discover Oncology
,17
(1)
INTRODUCTION: Breast cancer is the most prevalent malignancy among women worldwide. A significant portion of patients possess homologous recombination deficiency (HRD), often caused by BRCA1/2 mutations, which may sensitize ...
-
SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS
původní článek
open access
preprint
2026
BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...
-
Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+T and CD20+B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab
původní článek
open access
vydavatelská verze
2026
,Ivyspring International Publisher
,Journal of Cancer
,17
(2)
Background: Tumor-infiltrating lymphocytes (TILs) are known to influence disease progression and treatment response in clear cell renal cell carcinoma. This study aimed at evaluating the prognostic and predictive relevance ...
-
Familial colorectal cancer: search for novel predisposition genes
původní článek
open access
vydavatelská verze
2026
,Henry Stewart Publications
,Human Genomics
,20
(1)
BACKGROUND: Family history of colorectal cancer (CRC) and multiple primary CRCs in a single person may indicate inherited CRC predisposition. METHODS: In the present study, we performed whole exome/genome sequencing on ...
-
EVIDENCE BASED SELECTION OF HYPERPARAMETERS FOR EPITHELIAL SEGMENTATION IN WHOLE SLIDE IMMUNOHISTOCHEMISTRY IMAGES: FROM NORMAL MUCOSA TO COLORECTAL CANCER
původní článek
open access
preprint
2026
Background. Accurate delineation of the epithelial compartment is a critical prerequisite for reproducible quantitative analysis in digital pathology, particularly in colorectal cancer (CRC) where malignant glands determine ...
-
Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
původní článek
open access
vydavatelská verze
2026
,Springer
,Cancer Immunology, Immunotherapy
,75
(1)
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
-
Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study
původní článek
open access
vydavatelská verze
2026
,Springer-Verlag France
,Hernia
,30
(1)
PURPOSE: Incisional hernia is a common postoperative complication following abdominal surgery. Despite the use of synthetic meshes, recurrence rates remain high. This study aimed to develop and evaluate a biodegradable, ...
-
Mutational landscape of lung adenocarcinoma in Czechia
původní článek
open access
vydavatelská verze
2026
,Elsevier Inc.
,Cancer Treatment and Research Communications
,46
(January)
Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...
-
Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
-
Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
vydavatelská verze
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
RSS 1.0