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The HBV-induced microenvironment impairs the antiviral immune response triggered by TLR9 stimulation in human peripheral immune cells
abstract in e-form
open access
accepted version
2025
,Berlín
Hepatitis B virus (HBV) causes acute liver inflammation and leads chronic hepatitis, accountingfor approximately 1 million deaths from hepatocellular carcinoma and cirrhosis annually.Worldwide, more than 350 million people ...
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The cGAS-STING pathway activation triggers a novel monocyte cell death, a potential regulatory mechanism of antiviral cytokine secretion
abstract in e-form
open access
accepted version
2025
,Berlín
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
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Cold, Hot, and Lethal-The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell Carcinoma
summarizing article
open access
published version
2025
,MDPI Center
,International Journal of Molecular Sciences
,26
(18)
Head and neck squamous cell carcinomas (HNSCCs) represent a diverse group of malignancies, both clinically and biologically, with human papillomavirus (HPV) infection playing a significant role. HPV-positive tumours generally ...
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One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study
original article
open access
published version
2025
,Blackwell Publishing
,Cancer Medicine
,14
(18)
OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...
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Beyond the label: Students’ view of placement and replacement in between-class ability grouping
original article
open access
published version
2025
,Elsevier Ltd.
,International Journal of Educational Research Open
,9
(Neuveden)
Ability grouping is a common practice aimed at improving learning outcomes by targeting students' abilities, yet research on students' perspectives is limited. This study explores the views of 20 lower secondary school ...
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Achievement vs. engagement: Providing support in socially disadvantaged schools
original article
embargoed access
published version
2025
,Carfax
,British Educational Research Journal
,51
(2)
Educational inequalities persist between students of low socioeconomic status and their more affluent peers. At the same time, there is evidence of positive relations between student engagement and achievement. This multiple ...
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LVSP and LBBP result in similar or improved LV synchrony and hemodynamics compared to BVP
original article
open access
published version
2024
,JACC: Clinical Electrophysiology
,10
(7, Part 2)
Background The effect of left ventricular myocardial septal (LVSP) and left bundle branch pacing (LBBP) on ventricular synchrony and LV hemodynamics is poorly understood. Objective To investigate the impact of LVSP and ...
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Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts
original article
open access
published version
2025
,Springer
,Histochemistry and Cell Biology
,163
(1)
Cancer-associated fibroblasts (CAFs) represent an important component of the cancer ecosystem, influencing the broad scale of biological properties of tumour cells, including the capacity for metastasis formation. An ...
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Neutrophil Extracellular Traps and Thrombolysis Resistance: New Insights for Targeting Therapies
original article
open access
published version
2024
,Stroke
,55
(4)
BACKGROUND: Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi ...
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Sex specific familial risk in lung cancer through changing histologies in Sweden
original article
open access
published version
2025
,Wiley-Liss
,International Journal of Cancer
,157
(5)
Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in ...
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cfHPV DNA v plazmě a slinách jako biomarker pro monitorování léčby u pacientů s HPVpozitivním karcinomem orofaryngu
cfHPV DNA in plasma and saliva as a biomarker for monitoring treatment in patients with HPV-positive
oropharyngeal carcinomaabstract in e-form
open access
accepted version
2025
,Lípa
,Produkce BPP s.r.o.
,Sborník abstrakt
Volná buněčná DNA (cfDNA) z tekutých biopsií představuje slibný diagnostický aprognostický biomarker u nádorových onemocnění, včetně karcinomu orofaryngu (OPC),který je často etiologicky spojen s infekcí lidským papilomavirem ...
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Transformative progress in Raman optical activity: recent advances and innovations
summarizing article
open access
published version
2025
,Applied Spectroscopy Reviews
,Neuveden
(11.5.2025)
Raman optical activity (ROA) is a unique chiroptical spectroscopic technique that provides detailed structural insights into chiral molecules by measuring the differential intensity of Raman scattering for right-and ...
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Neural Dynamics of Visual Stream Interactions During Memory-Guided Actions Investigated by Intracranial EEG
original article
open access
published version
2025
,Neuroscience Bulletin
,41
(8)
The dorsal and ventral visual streams have been considered to play distinct roles in visual processing for action: the dorsal stream is assumed to support real-time actions, while the ventral stream facilitates memory-guided ...
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Co vlastně chtějí? Limity výzkumu zjišťujícího požadavky rodičů na kvalitní základní vzdělávání
What do they actually want? The limits of research determining parents' requirements for quality primary education
original article
open access
published version
2025
,Sociologický časopis / Czech Sociological Review
,2025
(2025)
Studie analyzuje výzvy při identifikaci preferencí rodičů týkajících se kvalitního povinného vzdělávání jejich dětí. První část představuje zjištění z dvou kvantitativních průzkumů provedených na reprezentativních vzorcích ...
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Pro-war hardline influencers in Putin’s regime in the context of Russia’s re-invasion of Ukraine
original article
open access
published version
2025
,Post-Soviet Affairs
,41
(4)
This paper explores why Putin's regime benefits from the activities of pro-war ultra-nationalist hardliners during the war against Ukraine despite their harsh criticism. While the regime appears stable and without significant ...
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The mediating role of formative feedback environment in the relationship between distributed school leadership and teacher job satisfaction in Czechia: Does school size matter?
original article
open access
published version
2025
,SAGE Publications
,Educational management administration & leadership
,Neuveden
(Neuvedeno)
Distributed leadership has been associated with enhanced teacher job satisfaction, particularly through school climate of mutual collaboration and trust, and teacher empowerment. Other school-level conditions have received ...
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Semi-automated RNA Isolation from Tempus Blood RNA Tubes Using the Magcore Plus II Instrument
original article
open access
published version
2025
,Folia Biologica
,71
(2)
High-throughput, precise and cost-effective isolation of high-quality RNA is essential for the growing number of RNA-based next-generation sequencing (NGS) analyses. Manual RNA isolation provides sufficient quality but ...
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Teachers’ Opinions on Kindergarten Admission Standards: Risks to Toddler Well-Being?
original article
open access
published version
2025
,Založba PEF, Pedagoška fakulteta
,Revija za Elementarno Izobraževanje
,18
(Special Issue)
The aim of this paper is to present the opinions of teachers on the standards for admitting toddlers to kindergartens in the Czech Republic and Slovakia, and to discuss these standards in relation to the risks to children's ...
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Myocardial Damage, Inflammation, Coagulation, and Platelet Activity During Catheter Ablation Using Radiofrequency and Pulsed-Field Energy
original article
open access
published version
2024
,JACC: Clinical Electrophysiology
,10
(3)
BACKGROUND: Pulsed-field ablation (PFA) represents a new, nonthermal ablation energy for the ablation of atrial fibrillation (AF). Ablation energies producing thermal injury are associated with an inflammatory response, ...
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Significant hemolysis is present during irreversible electroporation of cardiomyocytes in vitro
original article
open access
published version
2025
,Heart Rhythm
,22
(2)
BACKGROUND: Pulsed-field ablation (PFA) of atrial fibrillation (AF) is a new method in clinical practice. Despite a favorable safety profile of PFA in AF ablation, rare cases of renal failure, probably due to hemolysis, ...
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