Přírodovědecká fakulta
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Poslední příspěvky
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Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Bioorganic and Medicinal Chemistry Letters
,130
(January)
Ferroptosis is a regulated form of cell death characterized by lipid peroxidation and excessive reactive oxygen species (ROS) accumulation, which are driven primarily by iron dysregulation. It plays a critical role in ...
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TRAF6 Drives Dual Innate Immune Pathways During MPyV Infection: TLR4 and cGAS–STING
abstrakt v elektronické podobě
open access
postprint
2025
,Immunobiology of Pattern Recognition Receptors
A variety of pattern recognition receptors (PRRs) can simultaneously detect pathogens and trigger a broad spectrum of innate immune responses. Recent studies have increasingly highlighted the complex interplay between ...
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The role of snowmelt, glacier melt and rainfall in streamflow dynamics on James Ross Island, Antarctic Peninsula
původní článek
open access
vydavatelská verze
2025
,Copernicus Publ.
,Cryosphere
,19
(7)
The Antarctic Peninsula is experiencing a rapid increase in air temperature, which has a major impact on the entire ecosystem, including the runoff process. Understanding the water balance dynamics in such a fragile and ...
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Moisture governs diesel biodegradation in sand soil – polystyrene microplastic have a negligible impact
původní článek
open access
vydavatelská verze
2025
,Elsevier Science
,Journal of Hazardous Materials
,2025
(498)
Global plastic production has reached 450 million tons annually, yet less than 15 % is recycled, with nearly onethird entering the environment, often as microplastics. This study investigates how microplastics influence ...
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UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of Hepatitis B virus maturation and egress
původní článek
open access
vydavatelská verze
2025
,American Society for Biochemistry and Molecular Biology
,Journal of Biological Chemistry
,301
(11)
A critical step in Hepatitis B virus (HBV) maturation and egress is the ubiquitination of the capsid/core protein (HBc), which enables its recognition by the endosomal sorting complex required for transport (ESCRT) machinery ...
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Glial Activation Enhances Spinal TRPV1 Receptor Sensitivity in a Paclitaxel Model of Neuropathic Pain
původní článek
embargo
vydavatelská verze
2025
,Institute of Physiology, Academy of Sciences of the Czech Republic
,Physiological Research
,74
(3)
Paclitaxel (PTX), a commonly used chemotherapeutic, frequently leads to chemotherapy-induced peripheral neuropathy (CIPN), characterized by persistent pain and neuronal hypersensitivity. While its effects on peripheral ...
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Dissecting Isoform-Specific Functions of PML in Innate Antiviral Immunity Using a Murine Polyomavirus Model
abstrakt v elektronické podobě
open access
postprint
2025
,UNIL
,Immunobiology of Pattern Recognition Receptors
The promyelocytic leukemia (PML/TRIM19) protein, a member of theTRIM family, serves as the main scaffold component of PML nuclearbodies (PML NBs), dynamic, multiprotein organelles involved in diversecellular processes ...
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Mass spectrometric profiling of microbial polysaccharides using laser desorption/ionization – time-of-flight (LDI-TOF) and liquid chromatography-mass spectrometry (LC-MS): a novel method for structural fingerprinting and derivatization
původní článek
open access
vydavatelská verze
2025
,Frontiers Media S.A.
,Frontiers in Cellular and Infection Microbiology
,15
(October)
Introduction: Over the last two decades, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been introduced into the routine diagnostic practice of microbiological laboratories ...
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The HBV-induced microenvironment impairs the antiviral immune response triggered by TLR9 stimulation in human peripheral immune cells
abstrakt v elektronické podobě
open access
postprint
2025
,Berlín
Hepatitis B virus (HBV) causes acute liver inflammation and leads chronic hepatitis, accountingfor approximately 1 million deaths from hepatocellular carcinoma and cirrhosis annually.Worldwide, more than 350 million people ...
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The cGAS-STING pathway activation triggers a novel monocyte cell death, a potential regulatory mechanism of antiviral cytokine secretion
abstrakt v elektronické podobě
open access
postprint
2025
,Berlín
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
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Cold, Hot, and Lethal-The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell Carcinoma
přehledový článek
open access
vydavatelská verze
2025
,MDPI Center
,International Journal of Molecular Sciences
,26
(18)
Head and neck squamous cell carcinomas (HNSCCs) represent a diverse group of malignancies, both clinically and biologically, with human papillomavirus (HPV) infection playing a significant role. HPV-positive tumours generally ...
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cfHPV DNA v plazmě a slinách jako biomarker pro monitorování léčby u pacientů s HPVpozitivním karcinomem orofaryngu
cfHPV DNA in plasma and saliva as a biomarker for monitoring treatment in patients with HPV-positive
oropharyngeal carcinomaabstrakt v elektronické podobě
open access
postprint
2025
,Lípa
,Produkce BPP s.r.o.
,Sborník abstrakt
Volná buněčná DNA (cfDNA) z tekutých biopsií představuje slibný diagnostický aprognostický biomarker u nádorových onemocnění, včetně karcinomu orofaryngu (OPC),který je často etiologicky spojen s infekcí lidským papilomavirem ...
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Semi-automated RNA Isolation from Tempus Blood RNA Tubes Using the Magcore Plus II Instrument
původní článek
open access
vydavatelská verze
2025
,Folia Biologica
,71
(2)
High-throughput, precise and cost-effective isolation of high-quality RNA is essential for the growing number of RNA-based next-generation sequencing (NGS) analyses. Manual RNA isolation provides sufficient quality but ...
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Mitochondrial metabolism and hypoxic signaling in differentiated human cardiomyocyte AC16 cell line
původní článek
open access
vydavatelská verze
2025
,American Physiological Society
,American Journal of Physiology - Cell Physiology
,328
(5)
Cardiovascular diseases are associated with an altered cardiomyocyte metabolism. Because of a shortage of human heart tissue, experimental studies mostly rely on alternative approaches including animal and cell culture ...
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Polyglutamylation of microtubules drives neuronal remodeling
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. Regulation of the cytoskeleton is critical for this process, as microtubule loss via enzymatic severing is an early step ...
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Rapid trend towards larger and more moisture-limited trees in Central-European temperate forests
původní článek
open access
vydavatelská verze
2025
,Institute of Physics and IOP Publishing
,Environmental Research Letters
,20
(8)
Tree stems represent a long-lived biomass compartment for atmospheric carbon sequestration. While terrestrial biosphere models predict rising carbon sequestration in forests, direct observations of tree growth are inconclusive ...
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Expanding Blue Intensity applications: Exploring compression wood proportions in cross-sections of treeline Picea abies seedlings
původní článek
open access
vydavatelská verze
2025
,Urban u. Fischer
,Dendrochronologia
,93
(October)
Blue Intensity (BI) has been widely used as a proxy for wood density in dendrochronology, yet its applications remain underexplored in treeline ecology. Moving beyond traditional growth ring analyses, we expanded the Blue ...
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Adjective-based qualitative comparative analysis: Relating immobility situations across contexts
původní článek
open access
postprint
2025
,Institute of British Geographers
,Area
This paper introduces a novel adjective-based approach for conducting structured yet interpretive comparisons of case studies that explore the situated lived realities of diverse population groups. The method derives salient ...
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SENIOŘI NA PRACOVNÍM TRHU V JIŽNÍ KOREJI: VÝZVY DEMOGRAFICKÉHO STÁRNUTÍ
SENIORS IN THE SOUTH KOREAN WORKFORCE: THE CHALLENGES OF AN AGEING POPULATION
původní článek
open access
vydavatelská verze
2025
,Český statistický úřad
,Demografie
,67
(1)
Stárnutí populace je spojeno s mnoha výzvami, jednou z nejdiskutovanějších je udržitelnost sociálních a důchodových systémů. V souvislosti s prodlužující se střední délkou života je častým tématem například věk nároku na ...
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Heat Shock Protein Network: the Mode of Action, the Role in Protein Folding and Human Pathologies
přehledový článek
open access
vydavatelská verze
2024
,Univerzita Karlova v Praze, 1. lékařská fakulta
,Folia Biologica
,70
(3)
Protein folding is an extremely complicated process, which has been extensively tackled during the last decades. In vivo, a certain molecular machinery is responsible for assisting the correct folding of proteins and ...
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