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Poslední příspěvky
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Genetic Predisposition to Male Breast Cancer
původní článek
open access
vydavatelská verze
2024
,Univerzita Karlova v Praze, 1. lékařská fakulta
,Folia Biologica
,70
(5-6)
Male breast cancer (mBC) is a rare cancer diagnosis that constitutes less than 1 % of all breast cancer cases globally. Genetic factors play an important role in the mBC risk. Germline pathogenic variants (PVs) in cancer ...
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A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus
původní článek
open access
vydavatelská verze
2024
,Public Library of Science
,PLoS Neglected Tropical Diseases
,18
(12)
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous ...
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Studies on the BK Polyomavirus Life Cycle and Virus- Induced Membrane Remodelling in Human Microvascular Endothelial Cells
abstrakt v elektronické podobě
open access
postprint
2025
,ABSTRACT BOOK
BK polyomavirus (BKPyV) is a small, nonenveloped human DNA virus that establisheslifelong, asymptomatic infections. However, it can reactivate underimmunosuppression, leading to severe diseases such as BKPyV-associatednephropathy. ...
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Migrastatic therapy as a potential game-changer in adaptive cancer treatment
původní článek
open access
postprint
2026
,Springer Nature
,Scientific Reports
Adaptive therapy, which anticipates and counters the evolution of resistance in cancer cells, has gained significant traction, especially following the success of the Zhang et al.'s protocol in treating metastatic ...
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The role of myotubularin-related lipid phosphatases in cancer pathogenesis
přehledový článek
open access
vydavatelská verze
2026
,Academic Press
,Experimental and Molecular Pathology
,145
(January)
Myotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate. Several members have a well-established ...
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Low-Intensity Constant Light During Early Postnatal Development Induces Sex-Specific Anxiety-Like Behaviour and Region- and Sex-Specific Changes in Circadian Gene Expression and RNA Editing
původní článek
open access
postprint
2026
,Kluwer
,Cellular and Molecular Neurobiology
,Epub: 2025 Nov 25
(v tisku)
Early-life exposure to light at night can disrupt the maturation of the circadian system and lead to long-lasting behavioural and molecular alterations. We exposed rat pups to constant light (LL; 16 lx) from birth (P0) to ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
vydavatelská verze
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Střety zájmů při ochraně biodiverzity a klimatu a jejich řešení z pohledu práva = Conflicts of Interest in Biodiversity and Climate Protection and their Resolution from a Legal Perspective
Conflicts of Interest in Biodiversity and Climate Protection and their Resolution from a Legal Perspective
sborník
open access
vydavatelská verze
2025
,Praha
,Univerzita Karlova, Právnická fakulta
Změna klimatu a úbytek biodiverzity představují v současné době nejzávažnější glo- bální problémy životního prostředí. Podle modelu tzv. planetárních mezí či limitů Země,1 který vymezuje devět oblastí, devět limitů Země, ...
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Vaccinia virus mRNAs containing long 5'-poly(A)-leaders lack a canonical 5'-methylguanosine cap
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
The vaccinia virus (VACV) is a prototypical poxvirus that was originally used to eradicate smallpox. Half a century ago, investigation into VACV mRNA substantially contributed to the fundamental discovery of the 5' mRNA ...
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Investigating NFE2L1 Activators for Targeted Protein Aggregate Clearance: A Follow-Up Study
původní článek
open access
vydavatelská verze
2025
,Royal Society of Chemistry
,RSC Medicinal Chemistry
,16
(12)
Disruption of protein homeostasis (proteostasis), whether by acute proteotoxic stress or chronic expression of mutantproteins, can lead to the accumulation of toxic protein aggregates. Such aggregation is a hallmark of ...
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Intratumoral MHC-I Heterogeneity: Spatiotemporal Insights into the Immune Microenvironment
abstrakt v elektronické podobě
open access
postprint
2025
,ESMO Immuno-Oncology 2025 Abstract Book
The loss of major histocompatibility complex class I (MHC-I) molecules on tumor cells is a critical mechanism of resistance to cancer immunotherapy. However, the role of tumor MHC-I heterogeneity in shaping the immune ...
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Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
původní článek
open access
vydavatelská verze
2023
,SPRINGER
,Parasitology Research
,122
(10)
RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In ...
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N-Aryl-N-Lactosylamides as Potent and Highly Selective Inhibitors of Galectin-3 with Antifibrotic Activity
původní článek
open access
vydavatelská verze
2025
,ACS Publications
,Journal of Medicinal Chemistry
,68
(22)
Galectin-3 (Gal-3) is a galactose-binding lectin involved in pathologies such as inflammation, fibrosis, heart disease, and tumor progression. Here, we report N-aryl-N-(thio)lactosylamides as a novel class of Gal-3 inhibitors. ...
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Herbicides vs herbicidal ionic liquids - does the herbicide application form affect the properties of active components?
původní článek
open access
vydavatelská verze
2025
,ELSEVIER
,Journal of Hazardous Materials
,19
(August 2025)
Despite extensive research on ionic liquids (ILs), their environmental fate remains poorly understood. Cation toxicity is generally considered the primary determinant of the final properties of the ILs. However, the relevance ...
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MiR-146a secreted via EVs modulates TLR9 signalling in a cell model of chronic HBV infection
abstrakt v časopisu
open access
postprint
2025
,CzeSEV 2025 Meeting 2025
Hepatitis B virus (HBV) infection remains a major global health threat, with more than 250 million people chronically infected and at risk of cirrhosis and hepatocellular carcinoma. Infected hepatocytes release large amounts ...
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COVID-19 mortality data and level of democracy in post-communist countries: Data sources and accuracy
původní článek
open access
vydavatelská verze
2025
,Institute of Geonics, Czech Academy of Sciences v.v.i.
,Moravian Geographical Reports
,33
(3)
Emerging studies highlight the potential influence of different political regimes on COVID-19 mortality statistics reliability. This study has two objectives: first, to analyze COVID-19 mortality datasets and identify ...
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Decoding life expectancy gaps: a long-term decomposition analysis of three WHO European Region country groups
původní článek
open access
vydavatelská verze
2025
,Taylor & Francis
,Cogent Social Sciences
,11
(1)
Life expectancy at birth serves as a proxy measure of community health, indicating socio-economic development, healthcare accessibility, and the success of health policies. Observed differences in life expectancy among ...
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Reverse Genetics as a Key to Understanding Toscana Virus – Sand Fly Dynamics
abstrakt v konferenčním sborníku
open access
postprint
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(24)
The Toscana virus (TOSV), a member of the genus Phlebovirus Phenuiviridae, Hareavirales ), is a neglected human pathogen that can cause febrile illness, severe infection of the CNS, or remain asymptomatic. It is distributed ...
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Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection
původní článek
open access
vydavatelská verze
2025
,Cell Press, Elsevier, Inc.
,iScience
,28
(11)
Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined. We establish a mouse model of Toscana virus (TOSV) infection that incorporates ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
postprint
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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