Přírodovědecká fakulta
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Poslední příspěvky
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Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma
původní článek
open access
vydavatelská verze
2025
,Clinical and Experimental Medicine
,25
(May)
Genomic alterations and enormous monoclonal immunoglobulin production cause multiple myeloma to heavily depend on proteostasis mechanisms, including protein folding and degradation. These findings support the use of ...
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Coordinated implementation of a conventional PCR assay to detect all Ebola and Marburg virus species in a European laboratory network
původní článek
open access
vydavatelská verze
2025
,Journal of Clinical Virology
,178
(June)
Background: Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and primates. These viruses pose significant threats to public health, making rapid and sensitive detection critical ...
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Contaminant bioaccessibility in abandoned mine tailings in Namibia changes along a climatic gradient
původní článek
open access
vydavatelská verze
2025
,Environmental Science Processes & Impacts
,27
(4)
Fine-grained dust from tailing storage facilities in abandoned sulfide-ore mining areas represents an important source of environmental contamination. Fine fractions (<48 mu m and <10 mu m) of tailings from three old ...
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Susceptibility of diverse sand fly species to Toscana virus
původní článek
open access
vydavatelská verze
2025
,PLoS Neglected Tropical Diseases
,19
(5)
Toscana virus (TOSV) is an emerging but neglected human pathogen currently circulating around the Mediterranean basin including North Africa. Human illness ranges from asymptomatic or mild flu-like syndromes to severe ...
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Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat
původní článek
open access
vydavatelská verze
2024
,Frontiers in Microbiology
,15
(November)
The animal gut microbiome acts as a crucial link between the host and its environment, playing a vital role in digestion, metabolism, physiology, and fitness. Using 16S rRNA metabarcoding, we investigated the effect of ...
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The impact of buried historical copper slags on contemporary soil contamination
původní článek
open access
vydavatelská verze
2025
,Journal of Geochemical Exploration
,273
(June)
This study focuses on the impact of historical metallurgical slags on contemporary soil and soil pore water contamination, and potential phytoavailibility of metal(loid)s based on the example of the former smelter (16th-18th ...
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Evaluation of various membranes for blood-feeding in nine sand fly species and artificial feeding challenges in Sergentomyia minuta
původní článek
open access
vydavatelská verze
2025
,Parasites & Vectors
,18
(1)
BackgroundWe evaluated various membranes for blood-feeding in nine sand fly species from different genera and subgenera. Most of these species are vectors of human-pathogenic Leishmania, whereas Sergentomyia minuta is a ...
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Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection
původní článek
open access
postprint
2025
,Microbiology Spectrum
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometers have become an integral part of all modern clinical microbiology laboratories. They serve as the key tool for pathogen identification ...
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Dietary influence and immune balance: Regulating CD4+IEL responses and MHCII in the gut
přehledový článek
omezený přístup
vydavatelská verze
2025
,Mucosal Immunology
,18
(1)
Over the past decade, interest in CD4 positive intraepithelial lymphocytes (IELs) has been growing. This subset of long-overlooked helper T cell plays critical roles in intestinal homeostasis and in responses to intestinal ...
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Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs
přehledový článek
open access
vydavatelská verze
2024
,ACS Pharmacology & Translational Science
,8
(1)
The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in different life contexts need to be precisely ...
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Thermally-induced release of arsenic from minerals and phases relevant to polluted natural systems affected by wildfires
původní článek
open access
vydavatelská verze
2025
,Applied Geochemistry
,182
(March)
Fire-induced arsenic (As) emission from contaminated biomass or soil is dependent on its solid-phase speciation. To quantify the nature of this release, environmentally relevant As-bearing compounds (sulfides, sulfosalts, ...
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How to Measure Sustainable Housing: A Proposal for an Indicator-Based Assessment Tool
původní článek
open access
vydavatelská verze
2021
,Sustainability
,13
(3)
Housing drives urban development and has a significant potential for contributing to sustainability. However, ample sustainability indicator sets fail to include relevant indicators of sustainable housing-assessment seems ...
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An Analysis of Food Waste in Czech Households-A Contribution to the International Reporting Effort
původní článek
open access
vydavatelská verze
2021
,Foods [online]
,10
(4)
Food waste originating in households in the Czech Republic is an important but unknown issue. Due to the country's membership among the most developed economies (European Union, OECD) and its commitments towards UN Sustainable ...
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Automatic digital rock drawing using a "ladder style" representation
příspěvek v recenzovaném konferenčním sborníku
open access
postprint
2024
,Vídeň
,International Cartographic Association
,European Cartographic Conference – EuroCarto 2024
,2024
(7)
Topographic maps are a source of very detailed information about the terrain and serve as a basis for fieldwork in many sectors of human activity. Cartographic processing of areas with rock formations is often a rather ...
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The development of L. major, L. donovani and L. martiniquensis, Leishmania currently emerging in Europe, in the sand fly species Phlebotomus perniciosus and P. tobbi
původní článek
open access
vydavatelská verze
2024
,PLoS Neglected Tropical Diseases
,18
(10)
Background: Several new species of Leishmania have recently emerged in Europe, probably as the result of global changes and increased human migration from endemic areas. In this study, we tested whether two sand fly species, ...
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Microplastics originated from agricultural mulching films affect enchytraeid multigeneration reproduction and soil properties
původní článek
open access
vydavatelská verze
2024
,Journal of Hazardous Materials
,479
(November)
Microplastics (MPs) are increasingly entering agricultural soils, often from the breakdown of agricultural plastics (e.g., mulching films). This study investigates the effects of realistic MPs from different mulching films: ...
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Spatial immune heterogeneity in a mouse tumor model after immunotherapy
původní článek
open access
vydavatelská verze
2025
,Cancer Science
,116
(3)
Cancer immunotherapy is increasingly used in clinical practice, but its success rate is reduced by tumor escape from the immune system. This may be due to the genetic instability of tumor cells, which allows them to adapt ...
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Exploring vulnerability amplification in regional health inequality: COVID-19 case study in Czechia
původní článek
open access
vydavatelská verze
2025
,Applied Geography
,177
(April 2025)
This paper proposes a novel conceptual framework of vulnerability amplification to examine regional health inequalities. It combines differential vulnerability in health and social amplification of risk, as mechanisms of ...
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Azadirachtin disrupts ecdysone signaling and alters sand fly immunity
původní článek
open access
vydavatelská verze
2024
,Parasites & Vectors
,17
(1)
Background: Leishmaniasis is a group of neglected vector-borne diseases transmitted by phlebotomine sand flies. Leishmania parasites must overcome various defenses in the sand fly midgut, including the insects's immune ...
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Auer rod-positive acute leukemia with predominantly lymphoid immunophenotype: Report on 11 cases and review of literature
původní článek
open access
vydavatelská verze
2025
,Pediatric Blood and Cancer
,72
(1)
BACKGROUND: Auer rods (AuRs) are prominent intracellular structures found almost exclusively in myeloid cell malignancies, such as acute myeloid leukemia (AML), chronic and juvenile myelomonocytic leukemia and myelodysplastic ...
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