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Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia
letter to the editors
open access
vydavatelská verze
2025
,Haematologica
,110
(7)
Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable ...
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Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
původní článek
open access
vydavatelská verze
2025
,American Association for Cancer Research
,Clinical Cancer Research
,31
(3)
PURPOSE: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. EXPERIMENTAL DESIGN: We conducted an international retrospective cohort ...
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Souhrnná výzkumná zpráva projektu: Multiplatformní aplikace pro výuku a testování v hudební výchově, TAČR – TQ01000014
Summary research report of the project: Multiplatform applications for teaching and testing in music education
souhrnná výzkumná zpráva
embargo
draft
2025
Dokumentace obsahující Závěrečnou zprávu o postupu prací a dosažených výsledků - včetně příloh:1) Informace o otevřeném přístupu k výsledkům a datům;2) Evaluace hodin práce s aplikací;3 a 4) Dataset odpovědí studentů - ...
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Unveiling the complexity of pml nuclear bodies: identification of novel PML isoforms
abstrakt v konferenčním sborníku
open access
postprint
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Promyeloctic leukemia protein (PML) provides structural scaffolding within multiprotein, membraneless organelles known as PML nuclear bodies1. Originally discovered as a tumor suppressor, PML is associated with diverse ...
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Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors
původní článek
open access
vydavatelská verze
2025
,Cell Death Discovery
,11
(1)
A large body of evidence suggests that hypoxia drives aggressive molecular features of malignant cells irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common hematologic malignancies characterized by ...
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Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma
původní článek
open access
vydavatelská verze
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(1)
Background: Previous studies have suggested that, after acquisition of t(11;14), mantle cell lymphoma (MCL) pathogenesis may proceed via several different genetic second hits, which may shape different mutational profiles ...
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First Steps in the Development of a Multilevel Model of Resilience for the Czech Attitude Barometer Panel Survey (2024–2027)
původní článek
open access
vydavatelská verze
2025
,Karolinum
,Acta Universitatis Carolinae. Philosophica et Historica
,2025
(2022/2)
This paper presents a multilevel model of resilience for testing with the Czech Attitude Barometer panel survey (CAB, 2024-2027). Individual resilience is defined using the Brief Resilience Scale. Development of the ...
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Translation initiation at the 5’-polyadenylated and uncapped mRNAs from the yeast viruslike elements
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Linear cytoplasmic DNA plasmids pGKL1 and pGKL2, classified as virus-like elements (VLEs),have been found in the yeast Kluyveromyces lactis. VLEs encode a killer toxin and exhibit specificproperties, including host independent ...
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STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Cell Death Discovery
,11
(2025)
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in the cytoplasm, triggering the secretion of type I and III interferons and proinflammatory cytokines. However, ...
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Trends of Cu and Co contaminated sediment dispersal along the Kafue River, the Zambian Copperbelt
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Journal of Geochemical Exploration
,280
(January)
Rivers are important pathways for metal(loid) contamination in mining areas. The Kafue River flows through the Zambian Copperbelt with nearly a hundred-year history of Cu and Co mining. Nine cores down to 2.5 m deep were ...
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Interactome of Proteins Encoded by Cytoplasmic Linear Plasmids of the Yeast Kluyveromyces lactis
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Yeast linear dsDNA plasmids are found in certain yeast species, including Kluyveromyces lactis,Debaryomyces robertsiae, and Pichia acaciae. Due to their structural and functional similaritymainly to poxviruses, these ...
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Discovery of uncapped and 5 polyadenylated mRNAs in poxviruses and yeast virus-like elements comparison and similarities of both models
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Cytoplasmic double-stranded DNA virus-like elements (VLEs) are present in yeast species acrossnine genera. VLE archetypes are linear DNA elements pGKL1/2 from the yeast Kluyveromyceslactis . They exhibit unique features, ...
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Investigating the Impact of ADAR1 on HCV Replication
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Hepatitis C virus (HCV), a Flaviviridae family member with a +RNA genome, remains a globalhealth challenge despite the effectiveness of new direct-acting antivirals (DAAs). A preventivevaccine is still lacking. This report ...
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Deciphering Translational Regulation During the Cell Cycle Using Scarce Sample Polysome Profiling and Flow Cytometry
abstrakt v elektronické podobě
open access
postprint
2025
,Adam Mickiewicz University in Poznań
,Second Polish RNA Biology Meeting
mRNA Translation is a highly regulated process and even more so during cell cycle transitionwherein the activation or degradation of proteins mediate progression through the variousphases. Genome-wide studies including ...
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Interaction of Selected Anthracycline and Tetracycline Chemotherapeutics with Poly(I:C) Molecules
původní článek
open access
vydavatelská verze
2025
,American Chemical Society
,ACS Omega
,10
(16)
Despite the natural ability of the immune system to recognize cancer and, in some patients, even to eliminate it, cancer cells have acquired numerous evading mechanisms. With the increasing knowledge and focus shifting ...
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The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer
přehledový článek
open access
vydavatelská verze
2025
,Frontiers in Medicine
,12
(March)
Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer and neurodegenerative diseases, and they also display high usability in regenerative ...
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Impact of Asaia bacteria on Leishmania major development in sand flies: implications for vector control strategies
původní článek
open access
vydavatelská verze
2025
,BioMed Central
,Parasites & Vectors
,18
(1)
Background: Asaia spp., bacteria originally isolated from tropical plants, have also been identified in various insect species, including blood-feeding ones. Their ability to colonize different host tissues and transmit ...
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Interactions Between Monocarboxylate Transporter MCT1 Gene Variants and the Kinetics of Blood Lactate Production and Removal After High-Intensity Efforts: A Cross-Sectional Study
původní článek
open access
vydavatelská verze
2025
,Multidisciplinary Digital Publishing Institute (MDPI)
,Genes
,16
(10)
Background/Objectives: Lactate (LA) is a key metabolite in exercise metabolism, transported across cell membranes by monocarboxylate transporters (MCTs). Although genetic variation in MCT genes has been linked to LA kinetics, ...
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Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Bioorganic and Medicinal Chemistry Letters
,130
(January)
Ferroptosis is a regulated form of cell death characterized by lipid peroxidation and excessive reactive oxygen species (ROS) accumulation, which are driven primarily by iron dysregulation. It plays a critical role in ...
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Circulating tumour DNA as a predictor of survival of patients with diffuse large B-cell lymphoma in a daily practice
letter to the editors
open access
vydavatelská verze
2025
,Blackwell
,British Journal of Haematology
,online AoP
(07 September 2025)
Diffuse large B-cell lymphoma (DLBCL) is a relatively well treatable disease with long-term cure rates between 60% and 70% following standard front-line immunochemotherapy R-CHOP (i.e. rituximab, cyclophosphamide, doxorubicin, ...
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