1. lékařská fakulta
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Poslední příspěvky
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The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
původní článek
open access
vydavatelská verze
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
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Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
původní článek
open access
vydavatelská verze
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
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Comparative analysis of telomere length in peripheral blood of breast cancer BRCA1 mutation carriers and non-carriers
původní článek
open access
vydavatelská verze
2026
,Springer
,Discover Oncology
,17
(1)
INTRODUCTION: Breast cancer is the most prevalent malignancy among women worldwide. A significant portion of patients possess homologous recombination deficiency (HRD), often caused by BRCA1/2 mutations, which may sensitize ...
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SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS
původní článek
open access
preprint
2026
BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...
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Negative prognostic significance of primary cilia and cytoplasmic β-catenin expression in non-small cell lung cancer
původní článek
open access
vydavatelská verze
2024
,Cancer Research Institute of the Slovak Academy of Sciences
,Neoplasma
,71
(6)
The objective of this study was to investigate the prognostic significance of the frequency of primary cilia (PC) and β-catenin expression in 218 patients (pts) with non-small cell lung cancer (NSCLC), including 125 pts ...
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Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe
původní článek
open access
vydavatelská verze
2025
,Published for the Finnish Medical Society Duodecim by the Royal Society of Medicine Press
,Annals of Medicine
,57
(1)
Objective The aim of this study was to examine the prevalence of potentially inappropriate medication (PIM) use and its associated risk factors in community-dwelling older adults from five Central and Eastern European (CEE) ...
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Anticholinergic and Sedative Medication Burden in Croatian Older Adults: EuroAgeism Cohort Findings
původní článek
open access
vydavatelská verze
2025
,MDPI AG
,Pharmacy
,13
(5)
Use of anticholinergic and sedative medications is potentially inappropriate in older adults due to associated adverse effects, including impaired cognitive and physical function. This study evaluated anticholinergic and ...
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Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction - focus on large B-cell lymphomas and follicular lymphomas
přehledový článek
open access
vydavatelská verze
2025
,Informa Plc
,Expert Review of Molecular Diagnostics
,25
(6)
INTRODUCTION: Pathogenesis of large B-cell lymphomas (LBCL) and follicular lymphomas (FL) is a multistep process associated with development of diverse DNA alterations and consequent deregulation of critical cellular ...
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Deficiency of miR-155 in leukemic B-cells results in cell cycle arrest and deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network
původní článek
open access
vydavatelská verze
2025
,Archives of Medical Research
,56
(3)
Background. Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased ...
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Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study
původní článek
open access
vydavatelská verze
2026
,Elsevier España
,Annals of Hepatology
,31
(1)
Introduction and Objectives: Bilirubin is negatively associated with neurodegenerative diseases, including multiple sclerosis (MS). Since previous studies were small or did not evaluate all diagnostic aspects, the objective ...
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Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models
původní článek
open access
vydavatelská verze
2025
,Frontiers Media SA
,Frontiers in Oncology
,15
(December)
Introduction Head and neck cancers (HNC) remain a significant clinical challenge, particularly due to their association with chronic inflammation triggered by tobacco carcinogens and human papillomavirus (HPV) infection. ...
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Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promise
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Biomedicine & Pharmacotherapy
,194
(January)
Head and neck cancers remain among the most challenging malignancies to treat and are often linked to lifestyle-related risk factors such as smoking and alcohol consumption. These factors not only initiate tumor development ...
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Non-destructive in vivo tracking of gelatin hydrogels for advancing tissue engineering
původní článek
open access
draft
2025
,Communications Materials
,6
(1)
Photo-crosslinkable gelatin-based hydrogels hold great promise for tissue engineering and regenerative medicine. However, monitoring these hydrogels in vivo remains challenging and limits their further development and ...
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Sleep in Functional Motor Disorders: A Case-Control Polysomnographic Study
původní článek
open access
vydavatelská verze
2026
,Blackwell Science
,Journal of Sleep Research
,E-PUB
Sleep problems are frequent in functional motor disorders (FMDs). Surprisingly, objective correlates of impaired sleep and its relationship to other comorbidities have been understudied, and no polysomnographic study is ...
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Differential cued recall memory impairment in mild cognitive impairment due to Alzheimer's disease versus Parkinson's disease
původní článek
open access
vydavatelská verze
2026
,British Psychological Society
,Journal of Neuropsychology
,E-PUB
Both Alzheimer's (AD) and Parkinson's disease (PD) are often associated with memory dysfunction, but their pathophysiological underpinnings differ. The current research aimed to differentiate specific profiles of memory ...
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Genetic Predisposition to Male Breast Cancer
původní článek
open access
vydavatelská verze
2024
,Univerzita Karlova v Praze, 1. lékařská fakulta
,Folia Biologica
,70
(5-6)
Male breast cancer (mBC) is a rare cancer diagnosis that constitutes less than 1 % of all breast cancer cases globally. Genetic factors play an important role in the mBC risk. Germline pathogenic variants (PVs) in cancer ...
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Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia
původní článek
open access
vydavatelská verze
2026
,John Wiley & Sons
,Movement Disorders
,41
(1)
Background: Although many individuals with dystonia present with features indicative of single-gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective: We assessed the value of nanopore-based ...
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Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
původní článek
open access
vydavatelská verze
2025
,Sleep Medicine
,129
(May)
Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study ...
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Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease
příspěvek v recenzovaném konferenčním sborníku
open access
vydavatelská verze
2025
,EDP Sciences
,Bio Web of Conferences
,195
Parkinson’s disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. ...
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Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson's disease
původní článek
open access
vydavatelská verze
2025
,IOS Press
,Journal of Parkinson's Disease
,15
(8)
Background: Given the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link ...
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