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Poslední příspěvky
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Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort
původní článek
open access
vydavatelská verze
2026
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,32
(1)
Background Telomere shortening and mitochondrial dysfunction are well-known independent contributors to many diseases, but emerging evidence suggests a reciprocal relationship between the two processes. The role of the ...
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Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry
původní článek
open access
vydavatelská verze
2026
,Sage
,Therapeutic Advances in Neurological Disorders
,19
(April)
Background: Late-onset multiple sclerosis (LOMS), defined by symptom onset after age 50, is increasingly recognised as a distinct clinical entity. Evidence comparing disease-modifying therapies (DMTs) in this subgroup ...
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Does motherhood increase the risk of developing subsequent malignant neoplasms after childhood cancer treatment?
původní článek
open access
vydavatelská verze
2026
,Elsevier Ltd.
,Cancer Epidemiology
,101
(April)
BACKGROUND: Most young women who have survived childhood cancer express a desire to have children. Many of them are concerned about the potential adverse impact of pregnancy on their health, which has been affected by prior ...
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Discovery of Novel Murine PML Isoforms
původní článek
open access
vydavatelská verze
2026
,Landes Bioscience
,Nucleus
,17
(1)
Promyelocytic leukemia protein (PML) orchestrates the formation of PML nuclear bodies (PML NBs), membraneless organelles with diverse regulatory roles. Despite their importance, the specific functions of individual PML ...
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Elucidation of new sulfamethoxazole catabolic pathways in whole-cell catalyst of bacterium Kocuria rhizophila SA117
původní článek
open access
vydavatelská verze
2025
,Bioresource Technology
,435
(November)
Sulfamethoxazole (SMX) and its residues exhibit high environmental persistence due to their resistance to conventional degradation processes. The bacterial strain Kocuria rhizophila SA117, isolated from polluted soils, was ...
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The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
původní článek
open access
vydavatelská verze
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
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Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
původní článek
open access
vydavatelská verze
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
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Comparative analysis of telomere length in peripheral blood of breast cancer BRCA1 mutation carriers and non-carriers
původní článek
open access
vydavatelská verze
2026
,Springer
,Discover Oncology
,17
(1)
INTRODUCTION: Breast cancer is the most prevalent malignancy among women worldwide. A significant portion of patients possess homologous recombination deficiency (HRD), often caused by BRCA1/2 mutations, which may sensitize ...
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SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS
původní článek
open access
preprint
2026
BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...
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Negative prognostic significance of primary cilia and cytoplasmic β-catenin expression in non-small cell lung cancer
původní článek
open access
vydavatelská verze
2024
,Cancer Research Institute of the Slovak Academy of Sciences
,Neoplasma
,71
(6)
The objective of this study was to investigate the prognostic significance of the frequency of primary cilia (PC) and β-catenin expression in 218 patients (pts) with non-small cell lung cancer (NSCLC), including 125 pts ...
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Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe
původní článek
open access
vydavatelská verze
2025
,Published for the Finnish Medical Society Duodecim by the Royal Society of Medicine Press
,Annals of Medicine
,57
(1)
Objective The aim of this study was to examine the prevalence of potentially inappropriate medication (PIM) use and its associated risk factors in community-dwelling older adults from five Central and Eastern European (CEE) ...
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Anticholinergic and Sedative Medication Burden in Croatian Older Adults: EuroAgeism Cohort Findings
původní článek
open access
vydavatelská verze
2025
,MDPI AG
,Pharmacy
,13
(5)
Use of anticholinergic and sedative medications is potentially inappropriate in older adults due to associated adverse effects, including impaired cognitive and physical function. This study evaluated anticholinergic and ...
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Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction - focus on large B-cell lymphomas and follicular lymphomas
přehledový článek
open access
vydavatelská verze
2025
,Informa Plc
,Expert Review of Molecular Diagnostics
,25
(6)
INTRODUCTION: Pathogenesis of large B-cell lymphomas (LBCL) and follicular lymphomas (FL) is a multistep process associated with development of diverse DNA alterations and consequent deregulation of critical cellular ...
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Deficiency of miR-155 in leukemic B-cells results in cell cycle arrest and deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network
původní článek
open access
vydavatelská verze
2025
,Archives of Medical Research
,56
(3)
Background. Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased ...
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Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study
původní článek
open access
vydavatelská verze
2026
,Elsevier España
,Annals of Hepatology
,31
(1)
Introduction and Objectives: Bilirubin is negatively associated with neurodegenerative diseases, including multiple sclerosis (MS). Since previous studies were small or did not evaluate all diagnostic aspects, the objective ...
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Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models
původní článek
open access
vydavatelská verze
2025
,Frontiers Media SA
,Frontiers in Oncology
,15
(December)
Introduction Head and neck cancers (HNC) remain a significant clinical challenge, particularly due to their association with chronic inflammation triggered by tobacco carcinogens and human papillomavirus (HPV) infection. ...
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Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promise
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Biomedicine & Pharmacotherapy
,194
(January)
Head and neck cancers remain among the most challenging malignancies to treat and are often linked to lifestyle-related risk factors such as smoking and alcohol consumption. These factors not only initiate tumor development ...
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Non-destructive in vivo tracking of gelatin hydrogels for advancing tissue engineering
původní článek
open access
vydavatelská verze
2025
,Communications Materials
,6
(1)
Photo-crosslinkable gelatin-based hydrogels hold great promise for tissue engineering and regenerative medicine. However, monitoring these hydrogels in vivo remains challenging and limits their further development and ...
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Sleep in Functional Motor Disorders: A Case-Control Polysomnographic Study
původní článek
open access
vydavatelská verze
2026
,Blackwell Science
,Journal of Sleep Research
,E-PUB
Sleep problems are frequent in functional motor disorders (FMDs). Surprisingly, objective correlates of impaired sleep and its relationship to other comorbidities have been understudied, and no polysomnographic study is ...
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Differential cued recall memory impairment in mild cognitive impairment due to Alzheimer's disease versus Parkinson's disease
původní článek
open access
vydavatelská verze
2026
,British Psychological Society
,Journal of Neuropsychology
,20
(1)
Both Alzheimer's (AD) and Parkinson's disease (PD) are often associated with memory dysfunction, but their pathophysiological underpinnings differ. The current research aimed to differentiate specific profiles of memory ...
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