2. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 41-60 z 73
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Direct 16S/18S rRNA Gene PCR Followed by Sanger Sequencing as a Clinical Diagnostic Tool for Detection of Bacterial and Fungal Infections: a Systematic Review and Meta-Analysis
přehledový článek
open access
vydavatelská verze
2023
,Journal of Clinical Microbiology
,61
(9)
rRNA gene Sanger sequencing is being used for the identification of cultured pathogens. A new diagnostic approach is sequencing of uncultured samples by using the commercial DNA extraction and sequencing platform SepsiTest ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
původní článek
open access
vydavatelská verze
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy
kazuistika
open access
vydavatelská verze
2023
,Child's Nervous System
,39
(9)
Pontine gliomas represent difficult to treat entity due to the location and heterogeneous biology varying from indolent low-grade gliomas to aggressive diffuse intrinsic pontine glioma (DIPG). Making the correct tumor ...
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Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7
původní článek
open access
vydavatelská verze
2023
,Clinical Immunology
,256
(November)
The aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional ...
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Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
původní článek
open access
vydavatelská verze
2023
,Scientific Reports
,13
(1)
The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection ...
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Does advanced maternal age explain the longer hospitalisation of mothers after childbirth?
původní článek
open access
vydavatelská verze
2023
,PLoS One
,18
(4)
BACKGROUND: Fertility postponement, which has comprised the most significant reproductive trend in developed countries over the last few decades, involves a number of social, personal and health consequences. The length ...
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Does Advanced Maternal Age Comprise an Independent Risk Factor for Caesarean Section? A Population-Wide Study
původní článek
open access
vydavatelská verze
2023
,International Journal of Environmental Research and Public Health
,20
(1)
The paper aims to investigate the association between the mother's age and the risk of caesarean section when controlling for health factors and selected socio-demographic characteristics. The analysis employs anonymized ...
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The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
původní článek
open access
vydavatelská verze
2023
,Nature Communications
,14
(1)
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, ...
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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
původní článek
open access
vydavatelská verze
2023
,Nature Communications
,14
(1)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified ...
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Human polyomaviruses in psoriasis patients on biologic treatment
abstrakt v elektronické podobě
open access
postprint
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
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Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease
původní článek
open access
vydavatelská verze
2022
,Leukemia
,36
(23)
Recently, we defined "CML-like" subtype of BCR::ABL1-positive acute lymphoblastic leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here we retrospectively analyzed prognostic relevance ...
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Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
letter to the editors
omezený přístup
vydavatelská verze
2023
,Blood Advances
,7
(10)
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse ...
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Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer
původní článek
open access
postprint
2023
,Molecular Oncology
,17
(10)
Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling ...
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Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy
původní článek
open access
vydavatelská verze
2023
,American Journal of Hematology
,98
(10)
Our knowledge of genetic aberrations, that is, variants and copy number variations (CNVs), associated with mantle cell lymphoma (MCL) relapse remains limited. A cohort of 25 patients with MCL at diagnosis and the first ...
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Hybrid coatings for orthopaedic implants formed by physical vapour deposition and microarc oxidation
původní článek
open access
vydavatelská verze
2022
,Materials and Design
,219
(July)
This study is focused on the preparation of new hybrid layers intended for surface modification of Ti-6Al-4V alloys for potential orthopaedic and dental applications. Combination of the technology of physical vapour ...
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Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?
původní článek
open access
postprint
2023
,Genes, Chromosomes & Cancer
,62
(12)
Rhabdomyosarcomas (RMS) constitute a heterogeneous spectrum of tumors with respect to clinical behavior and tumor morphology. The paternal uniparental disomy (pUPD) of 11p15.5 is a molecular change described mainly in ...
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Epidemiology of Methicillin-Resistant Staphylococcus aureus in Slovakia, 2020 - Emergence of an Epidemic USA300 Clone in Community and Hospitals
přehledový článek
open access
postprint
2023
,Microbiology spectrum
,11
(4)
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of health care-associated infections. Additionally, over the decades, the spread of community-associated (CA-MRSA) clones has become a serious problem. ...
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Clostridioides difficile infections were predominantly driven by fluoroquinolone-resistant Clostridioides difficile ribotypes 176 and 001 in Slovakia in 2018-2019
původní článek
open access
vydavatelská verze
2023
,International Journal of Antimicrobial Agents
,62
(July)
AIMS: We aimed to investigate Clostridioides difficile (CDI) epidemiology in Slovakian hospitals after the emergence of ribotype 176 (027-like) in 2016. METHODS: Between 2018 and 2019, the ECDC CDI surveillance protocol ...
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Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the faecal metabolome in children with coeliac disease autoimmunity: a randomised, double-blinded placebo-controlled clinical trial
původní článek
open access
vydavatelská verze
2023
,Frontiers in Nutrition
,10
(July)
INTRODUCTION: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten ...
