2. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 21-40 z 73
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Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia
letter to the editors
open access
vydavatelská verze
2024
,Haematologica
,109
(6)
We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients <10 years ...
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Clinical and molecular study of radiation-induced gliomas
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(1)
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG ...
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Pediatric basilar invagination: Unveiling a rare complication of inflammatory bowel disease unclassified
kazuistika
open access
vydavatelská verze
2024
,PM and R
,16
(7)
This case report details the presentation of an 8-year-old boy with atlantoaxial rotatory dislocation (AARD) and basilar invagination (BI), an exceedingly rare complication of inflammatory bowel disease unclassified (IBDU). ...
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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data
původní článek
open access
vydavatelská verze
2024
,Annals of Nutrition & Metabolism
,80
(3)
INTRODUCTION: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the ...
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Learning Support Systems: A Practical Guide to E-learning at CU
necertifikovaná metodika
open access
draft
2024
,Praha
,Univerzita Karlova, Nakladatelství Karolinum
This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...
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Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
původní článek
open access
vydavatelská verze
2024
,Leukemia
,38
(1)
Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treatment and for early detection of imminent relapse. In childhood AML, MRD is typically evaluated using ...
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
původní článek
open access
vydavatelská verze
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
původní článek
open access
vydavatelská verze
2022
,Acta Neuropathologica Communications
,10
(1)
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular ...
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Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model
původní článek
open access
vydavatelská verze
2024
,Hypertension Research
,47
(10)
Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable ...
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The differences in virome from distinct anatomical locations in psoriasis patients
abstrakt v elektronické podobě
open access
postprint
2024
,Praha
,Česká zemědělská univerzita
,CzechoSlovak Virology Conference 2024 : Book of Abstracts
,1
(1)
Psoriasis, a chronic autoimmune inflammatory disorder affecting 2-3% of the global population,exhibits a multifactorial aetiology with a significant genetic component and triggers such as trauma orinfection.
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Examining the Correlation Between Neurofilament Levels and Clinical Features in a Friedreich Ataxia Cohort from the Czech Republic
přednáška
omezený přístup
preprint
2023
Objective: Friedreich's ataxia (FA) is the most common autosomal recessive hereditary ataxia caused by a mutation in the FXNgene characterized by ataxia, dorsal root syndrome, scoliosis, cardiomyopathy, and other symptoms. ...
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Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status
původní článek
embargo
vydavatelská verze
2023
,Frontiers in Psychiatry [online]
,14
(March)
INTRODUCTION: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between ...
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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
přehledový článek
embargo
vydavatelská verze
2023
,Frontiers in Endocrinology
,14
(April)
Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...
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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
původní článek
embargo
vydavatelská verze
2023
,Hypertension Research
,46
(9)
The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...
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Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track?
letter to the editors
embargo
postprint
2023
,American Journal of Hematology
,98
(10)
We read with a great interest the paper focused on different minimal residual disease (MRD) approaches and its significance in Ph+ acute lymphoblastic leukemia (ALL) patients, authored by Short et al. from the MD Anderson ...
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Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL
letter to the editors
open access
vydavatelská verze
2023
,HemaSphere
,7
(9)
We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, themost frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter ...
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Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry
původní článek
open access
postprint
2024
,Macromolecular Bioscience
,24
(2)
Herein, an advanced bioconjugation technique to synthesize hybrid polymer-antibody nanoprobes tailored for fluorescent cell barcoding in flow cytometry-based immunophenotyping of leukocytes is applied. A novel approach of ...
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The KMT2A recombinome of acute leukemias in 2023
původní článek
open access
vydavatelská verze
2023
,Leukemia
,37
(5)
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients ...
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Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the ...
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A failure of Fourier transform infrared spectroscopy to type Burkholderia isolates from chronically infected patients with cystic fibrosis
letter to the editors
open access
postprint
2023
,Microbiology spectrum
,11
(6)
We noted high variability of isolates spectra that prevented assigning isolates to known ST. Moreover, the FT-IR failed to reliably determine whether a chronic patient harbored the same Burkholderia strain over the course ...