2. Faculty of Medicine: Recent submissions
Now showing items 61-75 of 75
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Clostridioides difficile infections were predominantly driven by fluoroquinolone-resistant Clostridioides difficile ribotypes 176 and 001 in Slovakia in 2018-2019
original article
open access
published version
2023
,International Journal of Antimicrobial Agents
,62
(July)
AIMS: We aimed to investigate Clostridioides difficile (CDI) epidemiology in Slovakian hospitals after the emergence of ribotype 176 (027-like) in 2016. METHODS: Between 2018 and 2019, the ECDC CDI surveillance protocol ...
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Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the faecal metabolome in children with coeliac disease autoimmunity: a randomised, double-blinded placebo-controlled clinical trial
original article
open access
published version
2023
,Frontiers in Nutrition
,10
(July)
INTRODUCTION: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten ...
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An emerging Panton-Valentine leukocidin (PVL)-positive CC5-meticillin-resistant Staphylococcus aureus-IVc clone recovered from hospital and community settings over a 17-year period from 12 countries investigated by whole-genome sequencing
original article
open access
published version
2023
,Journal of Hospital Infection
,132
(February)
BACKGROUND: A novel Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC)5-MRSA-IVc ('Sri Lankan' clone) was recently described from Sri Lanka. Similar isolates ...
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NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on MRD-based protocol
original article
open access
published version
2023
,Blood
,141
(5)
We compared minimal residual disease (MRD) levels evaluated by routinely used real-time quantitative PCR (qPCR) patient-specific assays and by next generation sequencing (NGS) approach in 780 immunoglobulin/T-cell receptor ...
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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
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Moderating effect of cognitive reserve on brain integrity and cognitive performance
original article
open access
published version
2022
,Frontiers in Aging Neuroscience
,14
(November)
BACKGROUND: Dementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is ...
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Alzheimer's Disease Severity Is Associated with an Imbalance in Serum Levels of Enzymes Regulating Plasmin Synthesis
original article
open access
published version
2022
,Pharmaceuticals
,15
(9)
Alzheimer's disease (AD) is a central nervous system (CNS) disease characterized by loss of memory, cognitive functions, and neurodegeneration. Plasmin is an enzyme degrading many plasma proteins. In the CNS, plasmin may ...
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Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register
original article
embargoed access
published version
2022
,Pediatric Diabetes
,23
(7)
OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...
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The evaluation of an automated mariPOC SARS-CoV-2 antigen test compared to RT-qPCR SARS-CoV-2 assay and comparison of its sensitivity in Delta- and Omicron-variant samples
original article
embargoed access
published version
2022
,Influenza and other Respiratory Viruses [online]
,16
(6)
Background The rapid diagnostics tests for SARS-CoV-2 antigen vary in their sensitivities, and moreover, genomic mutations may further affect the performance of the assays. We aimed to evaluate the analytical performance ...
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Gut microbiome diversity of porcine peritonitis model of sepsis
original article
embargoed access
published version
2022
,Scientific Reports
,12
(1)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...
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Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy
original article
embargoed access
published version
2022
,Life Science Alliance
,5
(12)
Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected ...
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Emerging Patterns of Microbiome and Resistome in The Healthcare Environment
abstract in conference proceedings
open access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
The project led by Prof. Dřevinek at the 2nd Faculty ofMedicine has two main research objectives (see below).Active collaboration with the groups in the consortium isplanned.Research objective 1: Molecular epidemiology ...
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New concepts in antimicrobial resistance in cystic fibrosis respiratory infections
summarizing article
open access
published version
2022
,Journal of Cystic Fibrosis
,21
(6)
In this review, we summarize the main points that were raised and highlighted during the pre-conference meeting to the 17(th) European Cystic Fibrosis Society Basic Science Conference, held from 30 March to 2 April, 2022 ...
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Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?
original article
embargoed access
published version
2022
,International Journal of Infectious Diseases
,124
(November)
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal ...
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PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
original article
embargoed access
published version
2022
,Biomedicines
,10
(11)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
