Zobrazují se záznamy 1-20 z 1350

    • Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs 

      původní článek

      open access

      postprint

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      Sedláček, Jindřich

      2024

      ,

      ACS Pharmacology & Translational Science

      ,

      8

      (1)

      The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in different life contexts need to be precisely ...

    • Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review 

      přehledový článek

      open access

      vydavatelská verze

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      Vrabec, Rudolf

      ;

      Drašar, Pavel

      ;

      Opletal, Lubomír

      ;

      Kosturko, Štefan

      ;

      Blunden, Gerald

      ;

      Cahlíková, Lucie

      2025

      ,

      Phytochemistry Reviews

      ,

      Neuveden

      (29.3.2025)

      This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest ...

    • Thermally-induced release of arsenic from minerals and phases relevant to polluted natural systems affected by wildfires 

      původní článek

      open access

      vydavatelská verze

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      Tuhý, Marek

      ;

      Ettler, Vojtěch

      ;

      Rohovec, Jan

      ;

      Stonová, Kateřina

      ;

      Matoušková, Šárka

      ;

      Drahota, Petr

      ;

      Sullivan, Andrew L.

      2025

      ,

      Applied Geochemistry

      ,

      182

      (March)

      Fire-induced arsenic (As) emission from contaminated biomass or soil is dependent on its solid-phase speciation. To quantify the nature of this release, environmentally relevant As-bearing compounds (sulfides, sulfosalts, ...

    • Structural Insights and Functional Impact of the MmpL3 Inhibitor C215 

      abstrakt v konferenčním sborníku

      open access

      vydavatelská verze

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      Kovář, Ondřej

      ;

      Finger, Vladimír

      ;

      Kufa, Martin

      ;

      Roh, Jaroslav

      ;

      Korábečný, Jan

      2024

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      Tuberculosis TB is a globally prevalent infectious disease caused by Mycobacterium tuberculosis (Mtb). We developed a straightforward synthesis of C215 and its derivatives and established a basic pharmacological profile.

    • How and why does demographic decline lead to support for populist parties? The case of the Czech Republic 

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      open access

      vydavatelská verze

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      Dvořák, Tomáš

      ;

      Zouhar, Jan

      ;

      Bíba, Jan

      2025

      ,

      Political Geography

      ,

      117

      (Neuveden)

      In recent decades, a strong demographic decline has characterized post-communist Central and Eastern European countries. Using the Czech Republic as a case study, we apply a multilevel structural equation model to test the ...

    • Istorik–emigrant V. V. Sachaněv kak issledovatěl' Vostočnoj Slovakii i Podkarpatskoj Rusi 

      Ethnographer-emigrant V.V. Sachaněv as a researcher of Carpathian Rus' in the materials of his personal archive

      původní článek

      open access

      vydavatelská verze

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      Horstink, Olga

      2024

      ,

      Dejiny

      ,

      2024

      (1)

      Statja osnovana na materialach, obnaružennych v 2022 g. v Gosudarstvennom regionalnom archive v Prage (SOA v Praze) i otnosjaščichsja k ličnomu archivu russkogo etnografa, istorika, archeologa i archivista-emigranta Vsevoloda ...

    • Effects of 6 weeks of complex training on athletic performance and post-activation performance enhancement effect magnitude in soccer players: a cross-sectional randomized study 

      původní článek

      open access

      vydavatelská verze

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      Krzysztofik, Michal

      ;

      Jaros, Jakub

      ;

      Urbański, Robert

      ;

      Aschenbrenner, Piotr

      ;

      Šťastný, Petr

      2025

      ,

      Biology of Sport

      ,

      42

      (1)

      This study aimed to determine the effect of complex training (CT) on post-activation performance enhancement (PAPE) effect magnitude, 5- and 30-m linear sprint, 5-0-5 change of-direction (COD), back squat (BS) and hip ...

    • The Linked Complexity of Coseismic and Postseismic Faulting Revealed by Seismo‐Geodetic Dynamic Inversion of the 2004 Parkfield Earthquake 

      původní článek

      open access

      vydavatelská verze

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      Schliwa, Nico

      ;

      Gabriel, Alice-Agnes

      ;

      Premus, Jan

      ;

      Gallovič, František

      2024

      ,

      Journal of Geophysical Research: Solid Earth

      ,

      2024

      (November)

      Several regularly recurring moderate-size earthquakes motivated dense instrumentation of theParkfield section of the San Andreas fault (SAF), providing an invaluable near-fault observatory. We present aseismo-geodetic ...

    • Decoding Evolutionary Dynamics and Beyond 

      abstrakt v časopisu

      open access

      vydavatelská verze

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      Andrikopoulos, Prokopios

      ;

      Konar, Aditi

      ;

      Tian, Ruojin

      ;

      Zahradník, Jiří

      2024

      ,

      Praha

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      SARS-CoV-2 is continuously evolving to better adapt and stay ahead of the immune system's responses. Our goal is to uncover the evolutionary processes behind the changes in the Receptor Binding Domain (RBD), a hotspot for ...

    • Using the Campbell Paradigm to Understand the Role of Institutional Trust in Environmental Policy Support 

      původní článek

      open access

      vydavatelská verze

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      Urban, Jan

      ;

      Duda, Ewa Małgorzata

      2024

      ,

      International Journal of Sociology

      ,

      54

      (5-6)

      Previous studies have shown that institutional trust is associated with people's support for some environmental policies (e.g., support for higher taxation) but not others (e.g., support for subsidies and bans). Such ...

    • Consensus definition of advance care planning in dementia: A 33-country Delphi study 

      původní článek

      open access

      vydavatelská verze

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      van den Steen, Jenny T.

      ;

      Nakanishi, Miharu

      ;

      Van den Block, Lieve

      ;

      Di Giulio, Paola

      ;

      Gonella, Silvia

      ;

      in der Schmitten, Jürgen

      ;

      Sudore, Rebecca L.

      ;

      Harrison Dening, Karen

      ;

      Parker, Deborah

      ;

      Mimica, Ninoslav

      ;

      Holmerová, Iva

      ;

      Larkin, Philip

      ;

      Martins Pereira, Sandra

      ;

      Rietjens, Judith A. C.

      ;

      Korfage, Ida J.

      2024

      ,

      Alzheimer's and Dementia

      ,

      20

      (2)

      This article offers a consensus definitional framework of advance care planning in dementia. ACP in dementia was defined as a communication process adapted to the person's capacity, which includes, and is continued with, ...

    • Can corporate supply chain sustainability standards contribute to soil protection? 

      původní článek

      open access

      vydavatelská verze

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      Frouz, Jan

      ;

      Čemus, Vojtěch

      ;

      Frouzová, Jaroslava

      ;

      Peterková, Alena

      ;

      Kotecký, Vojtěch

      2024

      ,

      SOIL

      ,

      10

      (2)

      Companies increasingly view soil degradation in their supply chains as a commercial risk. They have applied sustainability standards to manage environmental risks stemming from suppliers' farming operations. To examine the ...

    • Syntéza kreativního učení a vzdělávání pro udržitelný rozvoj v České republice 

      Synthesis of creative learning and education for sustainable development in the Czech Republic

      původní článek

      open access

      vydavatelská verze

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      Macháčková Henderson, Laura

      ;

      Kuříková, Michaela

      ;

      Kroufek, Roman

      2021

      ,

      Envigogika

      ,

      16

      (2)

      Tento článek pojednává o pedagogickém přístupu Vzdělávání pro budoucnost (VpB) propojujícím dva vzájemně provázané podpůrné modely kompetencí: Klíčové kompetence pro udržitelnost (Rieckmann 2017) a Kreativní vzdělávání a ...

    • Energy expenditure and fuel choices among households in the Sidama region, Southern Ethiopia 

      původní článek

      open access

      vydavatelská verze

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      Legamo, Tarekegn Mamo

      ;

      Ščasný, Milan

      ;

      Tasew, Workalemahu

      2021

      ,

      International Journal of Energy Economics and Policy

      ,

      11

      (2)

      Using the data from an original survey, we analyse energy use patterns and, in particular, energy use for cooking in households from Hawassa City, Southern Ethiopia. Cooking is the main energy-related activity on which ...

    • How to Measure Sustainable Housing: A Proposal for an Indicator-Based Assessment Tool 

      původní článek

      open access

      vydavatelská verze

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      Adamec, Jakub

      ;

      Janoušková, Svatava

      ;

      Hák, Tomáš

      2021

      ,

      Sustainability

      ,

      13

      (3)

      Housing drives urban development and has a significant potential for contributing to sustainability. However, ample sustainability indicator sets fail to include relevant indicators of sustainable housing-assessment seems ...

    • An Analysis of Food Waste in Czech Households-A Contribution to the International Reporting Effort 

      původní článek

      open access

      vydavatelská verze

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      Nováková, Petra

      ;

      Hák, Tomáš

      ;

      Janoušková, Svatava

      2021

      ,

      Foods [online]

      ,

      10

      (4)

      Food waste originating in households in the Czech Republic is an important but unknown issue. Due to the country's membership among the most developed economies (European Union, OECD) and its commitments towards UN Sustainable ...

    • Complex characters of many kinds? : Gendered representation of inner states in reading anthologies for Czech primary schools 

      původní článek

      open access

      vydavatelská verze

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      Segi Lukavská, Jana

      ;

      Kuzmičová, Anežka

      2022

      ,

      L1-Educational Studies in Language and Literature

      ,

      22

      (1)

      L1 literacy instruction in Czechia largely relies on reading anthologies, i.e., textbooks containing short excerpts of literary texts from the 19th to 21st century. Focusing on current Year 3 anthologies (N = 13), wehave ...

    • Automatic digital rock drawing using a "ladder style" representation 

      příspěvek v recenzovaném konferenčním sborníku

      open access

      postprint

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      Kyncl, Günter

      ;

      Lysák, Jakub

      2024

      ,

      Vídeň

      ,

      International Cartographic Association

      ,

      European Cartographic Conference – EuroCarto 2024

      ,

      2024

      (7)

      Topographic maps are a source of very detailed information about the terrain and serve as a basis for fieldwork in manysectors of human activity. Cartographic processing of areas with rock formations is often a rather ...

    • Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies 

      původní článek

      open access

      vydavatelská verze

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      Laabs, Bjoern-Hergen

      ;

      Lohmann, Katja

      ;

      Vollstedt, Eva-Juliane

      ;

      Reinberger, Tobias

      ;

      Nuxoll, Lisa-Marie

      ;

      Kilic-Berkmen, Gamze

      ;

      Perlmutter, Joel S.

      ;

      Loens, Sebastian

      ;

      Cruchaga, Carlos

      ;

      Franke, Andre

      ;

      Dobricic, Valerija

      ;

      Hinrichs, Frauke

      ;

      Groezinger, Anne

      ;

      Altenmueller, Eckart

      ;

      Bellows, Steven

      ;

      Boesch, Sylvia

      ;

      Bressman, Susan B.

      ;

      Duque, Kevin R.

      ;

      Espay, Alberto J.

      ;

      Ferbert, Andreas

      ;

      Feuerstein, Jeanne S.

      ;

      Frank, Samuel

      ;

      Gasser, Thomas

      ;

      Haslinger, Bernhard

      ;

      Jech, Robert

      ;

      Kaiser, Frank

      ;

      Kamm, Christoph

      ;

      Kollewe, Katja

      ;

      Kuehn, Andrea A.

      ;

      LeDoux, Mark S.

      ;

      Lohmann, Ebba

      ;

      Mahajan, Abhimanyu

      ;

      Muenchau, Alexander

      ;

      Multhaupt-Buell, Trisha

      ;

      Pantelyat, Alexander

      ;

      Pirio Richardson, Sarah E.

      ;

      Raymond, Deborah

      ;

      Reich, Stephen G.

      ;

      Saunders Pullman, Rachel

      ;

      Schormair, Barbara

      ;

      Sharma, Nutan

      ;

      Sichani, Azadeh Hamzehei

      ;

      Simonyan, Kristina

      ;

      Volkmann, Jens

      ;

      Wagle Shukla, Aparna

      ;

      Winkelmann, Juliane

      ;

      Wright, Laura J.

      ;

      Zech, Michael

      ;

      Zeuner, Kirsten E.

      ;

      Zittel, Simone

      ;

      Kasten, Meike

      ;

      Sun, Yan V.

      ;

      Baeumer, Tobias

      ;

      Brueggemann, Norbert

      ;

      Ozelius, Laurie J.

      ;

      Jinnah, Hyder A.

      ;

      Klein, Christine

      ;

      Koenig, Inke R.

      2024

      ,

      Movement Disorders

      ,

      39

      (11)

      Background: Despite considerable heritability, previous smaller genome-wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia. Objective: The objective of this study was ...

    • Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network 

      původní článek

      open access

      vydavatelská verze

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      Lorscheider, Johannes

      ;

      Signori, Alessio

      ;

      Subramaniam, Suvitha

      ;

      Benkert, Pascal

      ;

      Vukusic, Sandra

      ;

      Trojano, Maria

      ;

      Hillert, Jan

      ;

      Glaser, Anna

      ;

      Hyde, Robert

      ;

      Spelman, Tim

      ;

      Magyari, Melinda

      ;

      Elberling, Frederik

      ;

      Pontieri, Luigi

      ;

      Koch-Henriksen, Nils

      ;

      Sorensen, Per Soelberg

      ;

      Gerlach, Oliver

      ;

      Prat, Alexandre

      ;

      Girard, Marc

      ;

      Eichau, Sara

      ;

      Grammond, Pierre

      ;

      Horáková, Dana

      ;

      Ramo-Tello, Cristina

      ;

      Roos, Izanne

      ;

      Buzzard, Katherine

      ;

      Scott, Jeanette Lechner

      ;

      Sanchez-Menoyo, Jose Luis

      ;

      Alroughani, Raed

      ;

      Prevost, Julie

      ;

      Kuhle, Jens

      ;

      Gray, Orla

      ;

      Mathey, Guillaume

      ;

      Michel, Laure

      ;

      Ciron, Jonathan

      ;

      De Seze, Jerome

      ;

      Maillart, Elisabeth

      ;

      Ruet, Aurelie

      ;

      Labauge, Pierre

      ;

      Zephir, Helene

      ;

      Kwiatkowski, Arnaud

      ;

      van der Walt, Anneke

      ;

      Kalincik, Tomas

      ;

      Butzkueven, Helmut

      2024

      ,

      Journal of Neurology, Neurosurgery and Psychiatry

      ,

      AHEAD OF PRINT

      (First published December 6, 2024)

      Background: Effectiveness of disease-modifying treatment (DMT) in people affected by primary progressive multiple sclerosis (PPMS) is limited. Whether specific subgroups may benefit more from DMT in a real-world setting ...