Fakulty: Poslední příspěvky
Zobrazují se záznamy 1-20 z 1572
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Translation initiation at the 5’-polyadenylated and uncapped mRNAs from the yeast viruslike elements
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Linear cytoplasmic DNA plasmids pGKL1 and pGKL2, classified as virus-like elements (VLEs),have been found in the yeast Kluyveromyces lactis. VLEs encode a killer toxin and exhibit specificproperties, including host independent ...
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STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Cell Death Discovery
,11
(2025)
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in the cytoplasm, triggering the secretion of type I and III interferons and proinflammatory cytokines. However, ...
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Trends of Cu and Co contaminated sediment dispersal along the Kafue River, the Zambian Copperbelt
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Journal of Geochemical Exploration
,280
(January)
Rivers are important pathways for metal(loid) contamination in mining areas. The Kafue River flows through the Zambian Copperbelt with nearly a hundred-year history of Cu and Co mining. Nine cores down to 2.5 m deep were ...
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Interactome of Proteins Encoded by Cytoplasmic Linear Plasmids of the Yeast Kluyveromyces lactis
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Yeast linear dsDNA plasmids are found in certain yeast species, including Kluyveromyces lactis,Debaryomyces robertsiae, and Pichia acaciae. Due to their structural and functional similaritymainly to poxviruses, these ...
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Discovery of uncapped and 5 polyadenylated mRNAs in poxviruses and yeast virus-like elements comparison and similarities of both models
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Cytoplasmic double-stranded DNA virus-like elements (VLEs) are present in yeast species acrossnine genera. VLE archetypes are linear DNA elements pGKL1/2 from the yeast Kluyveromyceslactis . They exhibit unique features, ...
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Investigating the Impact of ADAR1 on HCV Replication
abstrakt v elektronické podobě
open access
postprint
2025
,Second Polish RNA Biology Meeting
Hepatitis C virus (HCV), a Flaviviridae family member with a +RNA genome, remains a globalhealth challenge despite the effectiveness of new direct-acting antivirals (DAAs). A preventivevaccine is still lacking. This report ...
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Deciphering Translational Regulation During the Cell Cycle Using Scarce Sample Polysome Profiling and Flow Cytometry
abstrakt v elektronické podobě
open access
postprint
2025
,Adam Mickiewicz University in Poznań
,Second Polish RNA Biology Meeting
mRNA Translation is a highly regulated process and even more so during cell cycle transitionwherein the activation or degradation of proteins mediate progression through the variousphases. Genome-wide studies including ...
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Interaction of Selected Anthracycline and Tetracycline Chemotherapeutics with Poly(I:C) Molecules
původní článek
open access
vydavatelská verze
2025
,American Chemical Society
,ACS Omega
,10
(16)
Despite the natural ability of the immune system to recognize cancer and, in some patients, even to eliminate it, cancer cells have acquired numerous evading mechanisms. With the increasing knowledge and focus shifting ...
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The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer
přehledový článek
open access
vydavatelská verze
2025
,Frontiers in Medicine
,12
(March)
Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer and neurodegenerative diseases, and they also display high usability in regenerative ...
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Impact of Asaia bacteria on Leishmania major development in sand flies: implications for vector control strategies
původní článek
open access
vydavatelská verze
2025
,BioMed Central
,Parasites & Vectors
,18
(1)
Background: Asaia spp., bacteria originally isolated from tropical plants, have also been identified in various insect species, including blood-feeding ones. Their ability to colonize different host tissues and transmit ...
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Interactions Between Monocarboxylate Transporter MCT1 Gene Variants and the Kinetics of Blood Lactate Production and Removal After High-Intensity Efforts: A Cross-Sectional Study
původní článek
open access
vydavatelská verze
2025
,Multidisciplinary Digital Publishing Institute (MDPI)
,Genes
,16
(10)
Background/Objectives: Lactate (LA) is a key metabolite in exercise metabolism, transported across cell membranes by monocarboxylate transporters (MCTs). Although genetic variation in MCT genes has been linked to LA kinetics, ...
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Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Bioorganic and Medicinal Chemistry Letters
,130
(January)
Ferroptosis is a regulated form of cell death characterized by lipid peroxidation and excessive reactive oxygen species (ROS) accumulation, which are driven primarily by iron dysregulation. It plays a critical role in ...
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Circulating tumour DNA as a predictor of survival of patients with diffuse large B-cell lymphoma in a daily practice
letter to the editors
open access
vydavatelská verze
2025
,Blackwell
,British Journal of Haematology
,online AoP
(07 September 2025)
Diffuse large B-cell lymphoma (DLBCL) is a relatively well treatable disease with long-term cure rates between 60% and 70% following standard front-line immunochemotherapy R-CHOP (i.e. rituximab, cyclophosphamide, doxorubicin, ...
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Acceptability of meat tax and subsidy removal by meat eaters: insights from five European countries
původní článek
open access
vydavatelská verze
2025
,SPRINGERNATURE
,Agricultural and food economics
,13
(1)
Governments worldwide are exploring policies aimed at promoting healthier and more sustainable dietary choices. This study examines the public acceptability of two promising yet controversial policy interventions: the ...
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TRAF6 Drives Dual Innate Immune Pathways During MPyV Infection: TLR4 and cGAS–STING
abstrakt v elektronické podobě
open access
postprint
2025
,Immunobiology of Pattern Recognition Receptors
A variety of pattern recognition receptors (PRRs) can simultaneously detect pathogens and trigger a broad spectrum of innate immune responses. Recent studies have increasingly highlighted the complex interplay between ...
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The role of snowmelt, glacier melt and rainfall in streamflow dynamics on James Ross Island, Antarctic Peninsula
původní článek
open access
vydavatelská verze
2025
,Copernicus Publ.
,Cryosphere
,19
(7)
The Antarctic Peninsula is experiencing a rapid increase in air temperature, which has a major impact on the entire ecosystem, including the runoff process. Understanding the water balance dynamics in such a fragile and ...
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Citizenship Education Curriculum Making for Troubled Times
původní článek
open access
vydavatelská verze
2025
,Univerzita Karlova, Nakladatelství Karolinum
,Orbis scholae
,18
(3)
The rise of far-right forces in Europe, the increase in the number ofilliberal and autocratic regimes, and influence operations against European democracies call for anew role of citizenship education. While education ...
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The WANDA Reflective Method as a Tool for Improving Teachers’ Well-being
původní článek
open access
vydavatelská verze
2025
,Založba PEF, Pedagoška fakulteta
,Revija za Elementarno Izobraževanje
,18
(Special Issue)
This qualitative research study focuses on teachers' well-being in the context of the WANDA reflective method. The aim was to explore teachers' subjective perceptions of the benefits of WANDA on their well-being. Data were ...
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Multi-region investigation of 'man' as default in attitudes
původní článek
open access
vydavatelská verze
2025
,Public Library of Science
,PLoS One
,20
(6)
Previous research has studied the extent to which men are the default members of social groups in terms of memory, categorization, and stereotyping, but not attitudes which is critical because of attitudes' relationship ...
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Complex temporal dynamics of mental health indicators: A longitudinal network approach perspective
původní článek
open access
vydavatelská verze
2025
,Cambridge University Press
,Psychological Medicine
,55
(Neuveden)
Background Although mental disorders have long been considered complex dynamic systems, our understanding of the mutual interactions and temporal patterns of their symptoms remains limited.Methods In this longitudinal ...
