1. Faculty of Medicine: Recent submissions
Now showing items 81-100 of 109
-
Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents
original article
open access
published version
2022
,International Journal of Molecular Sciences [online]
,23
(12)
The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key regulator of hematopoiesis, whose level is influenced by transcription through its enhancers and its post-transcriptional degradation via microRNA-155 ...
-
CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS
original article
embargoed access
accepted version
2023
,International Journal of Molecular Sciences [online]
,24
(12)
In this prospective longitudinal study, we quantified regional brain volume and susceptibility changes during the first two years after the diagnosis of multiple sclerosis (MS) and identified their association with ...
-
Transcripts of vaccinia virus postreplicative genes do not contain a 5' methylguanosine cap
abstract in e-form
open access
accepted version
2023
,The 28th Annual Meeting of the RNA Society
Vaccinia virus (VACV) is a prototypical poxvirus originally used for eradication of smallpox. Investigation into VACV mRNAs carried out almost half a century ago substantially contributed to the fundamental discovery of ...
-
Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy
original article
open access
published version
2023
,American Journal of Hematology
,98
(10)
Our knowledge of genetic aberrations, that is, variants and copy number variations (CNVs), associated with mantle cell lymphoma (MCL) relapse remains limited. A cohort of 25 patients with MCL at diagnosis and the first ...
-
Health inequalities in post-COVID-19 outcomes among adults aged 50+ in Europe: has COVID-19 exposed divide between postcommunist countries and Western Europe?
original article
open access
published version
2023
,Journal of Epidemiology and Community Health
,77
(9)
Background: COVID-19 affected people and countries disproportionately and continues to impact the health of people. The aim is to investigate protective health and socio-geographical factors for post-COVID-19 conditions ...
-
Pathways to eating disorder care: A European multicenter study
original article
open access
published version
2023
,European Psychiatry
,66
(1)
Background: The aim of this study was to assess barriers and facilitators in the pathways toward specialist care for eating disorders (EDs). Methods: Eleven ED services located in seven European countries recruited patients ...
-
Prevalence of Dual Diagnoses among Children and Adolescents with Mental Health Conditions
original article
embargoed access
published version
2023
,Children-Basel [online]
,10
(2)
Background: The World Health Organisation defines dual diagnosis as the co-occurrence in the same individual of a psychoactive substance use disorder and another psychiatric disorder. Children and adolescents with dual ...
-
The dynamics of telomere length in primary and metastatic colorectal cancer lesions
original article
embargoed access
published version
2023
,Scientific Reports
,13
(1)
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...
-
MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
original article
open access
published version
2023
,Oncology Letters
,25
(2)
MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...
-
Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
original article
open access
published version
2022
,Biomedicine & Pharmacotherapy
,154
(October)
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging ...
-
COVID-19 Vaccination among Czech Dentists
original article
embargoed access
published version
2022
,Vaccines
,10
(3)
This work describes and evaluates vaccination against COVID-19 among members of the Czech Dental Chamber during the pre-booster vaccination phase. A cross-sectional online survey was conducted between 23 June and 4 September ...
-
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
original article
open access
submitted version
2022
,Journal of the National Cancer Institute
,114
(5)
BACKGROUND: Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type-2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. ...
-
Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
original article
open access
accepted version
2024
,Developmental Dynamics
,253
(1)
Background: The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function ...
-
AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
original article
open access
submitted version
2022
,bioRxiv
,PREPRINT
This article is a preprint and has not been certified by peer review.
-
Serum Bilirubin and Markers of Oxidative Stress and Inflammation in a Healthy Population and in Patients with Various Forms of Atherosclerosis
original article
open access
published version
2022
,Antioxidants
,11
(11)
Oxidative stress and inflammation contribute significantly to atherogenesis. We and others have demonstrated that mildly elevated serum bilirubin levels protect against coronary and peripheral atherosclerosis, most likely ...
-
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
original article
open access
published version
2022
,Metabolites [online]
,12
(12)
Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations ...
-
Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency
original article
open access
published version
2022
,Journal of Inherited Metabolic Disease
,45
(6)
Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to the development of Farber disease (FD). ...
-
Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia
original article
open access
published version
2022
,Brain Stimulation
,15
(5)
Background: Deep brain stimulation of the internal globus pallidus (GPi DBS) is an invasive therapeutic modality intended to retune abnormal central nervous system patterns and relieve the patient of dys-tonic or other ...
-
Sex bias in multiple sclerosis and neuromyelitis optica spectrum disorders: How it influences clinical course, MRI parameters and prognosis
summarizing article
open access
published version
2022
,Frontiers in Immunology
,13
(August)
This review is a condensed summary of representative articles addressing the sex/gender bias in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). The strong effects of sex on the incidence and ...
-
Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis
original article
open access
published version
2022
,BMC Neurology
,22
(1)
Background: Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse ...
