1. Faculty of Medicine: Recent submissions
Now showing items 101-109 of 109
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Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells
original article
open access
published version
2022
,Biomedicine & Pharmacotherapy
,155
(November)
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising ...
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Autosomal dominant tubulointerstitial kidney disease: A review
summarizing article
open access
published version
2022
,American Journal of Medical Genetics: Part C, Seminars in Medical Genetics
,190
(3)
The clinical characteristics of autosomal dominant tubulointerstitial kidney disease (ADTKD) include bland urinary sediment, slowly progressive chronic kidney disease (CKD) with many patients reaching end stage renal disease ...
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Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk
original article
open access
published version
2022
,Scientific Reports
,12
(1)
In the literature on the safety of ursodeoxycholic acid (UDCA) during breastfeeding, insufficient data has been reported to date. Thus, the aim of our study was to analyze bile acid (BA) concentrations in breast milk in a ...
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Otevřenost jako základ vědy a vědecké komunikace v 21. století
chapter in a collective monograph
open access
published version
2016
,Brno
,Nakladatelství VUTIUM
,Otevřený přístup k vědeckým informacím: současný stav v České republice a ve světě
Kapitola je obecným úvodem do problematiky otevřenosti ve vědě a vědecké komunikaci (koncept open science).
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Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial
original article
open access
published version
2023
,Nutrition & Diabetes [online]
,13
(1)
AIM: The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) ...
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Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators
original article
open access
published version
2022
,International Journal of Molecular Sciences
,23
(18)
Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated ...
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunities
summarizing article
open access
published version
2022
,Cells
,11
(22)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, ...
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Engine shutdown: Migrastatic strategies and prevention of metastases
summarizing article
embargoed access
published version
2023
,Trends in Cancer
,9
(4)
Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the ...
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PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
original article
embargoed access
published version
2022
,Biomedicines
,10
(11)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
