1. Faculty of Medicine: Recent submissions
Now showing items 61-80 of 109
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Fibrosis and expression of extracellular matrix proteins in human interventricular septum in aortic valve stenosis and regurgitation
original article
open access
published version
2024
,Histochemistry and Cell Biology
,161
(5)
Valvular heart disease leads to ventricular pressure and/or volume overload. Pressure overload leads to fibrosis, which might regress with its resolution, but the limits and details of this reverse remodeling are not known. ...
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Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure
original article
open access
published version
2024
,Frontiers in Endocrinology
,15
(March)
Introduction: Maternal diabetes is a recognized risk factor for both short-term and long-term complications in offspring. Beyond the direct teratogenicity of maternal diabetes, the intrauterine environment can influence ...
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Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model
original article
open access
published version
2024
,Hypertension Research
,47
(10)
Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable ...
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Díla Jana Marka Marci z Kronlandu ve fondu 1. lékařské fakulty Univerzity Karlovy
The Work of Johannes Marcus Marci of Cronland in the Book Collection of the First Faculty of Medicine at Charles University
original article
open access
published version
2020
,Knihy a dějiny
,27
(1-2)
Soubor šesti svazků (deseti děl) Jana Marka Marci z Kronlandu na 1. lékařské fakultě Univerzity Karlovy lze plným právem označit za průřezovou sbírku jeho děl. Vyznačují se vysokou uměleckou úrovní a dobrou typografií. ...
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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
original article
open access
published version
2024
,Biomarker Research
,12
(1)
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific ...
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Factors Influencing the Involvement of Nurses in Preventive Care and Health Literacy in the Czech Republic
original article
open access
published version
2023
,Central European Journal of Public Policy
,17
(2)
The aims of this article were to discuss the position of Czech nurses in the country's health care system, to assess their role in the preventive care and health literacy (HL) promotion and to define main factors, which ...
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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
original article
open access
published version
2023
,Journal of Cardiovascular Electrophysiology
,34
(9)
INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...
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Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy
original article
open access
published version
2023
,Nutrients
,15
(2)
Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan ...
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Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials
original article
open access
published version
2023
,Frontiers in Cardiovascular Medicine
,9
(January)
Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes ...
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Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery
original article
open access
published version
2023
,World Journal of Surgical Oncology
,21
(December)
Background: The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method: A total of 115 patients ...
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Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours
original article
open access
published version
2023
,Pathology
,55
(6)
Brain metastases are a very common and serious complication of oncological diseases. Despite the vast progress in multimodality treatment, brain metastases significantly decrease the quality of life and prognosis of patients. ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
original article
open access
published version
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis
original article
open access
published version
2023
,Histochemistry and Cell Biology
,160
(6)
Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of TGF-β1 and TGF-β3 on myofibroblast differentiation and extracellular matrix ...
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A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
original article
open access
published version
2023
,Gastroenterology
,165
(3)
BACKGROUND & AIMS: Fecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA ...
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Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
original article
open access
published version
2023
,In Vivo
,37
(5)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...
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The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
abstract in conference proceedings
open access
published version
2023
,Czech Chemical Society Symposium Series
,21
(5)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
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Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
abstract in conference proceedings
open access
accepted version
2023
,Czech Chemical Society Symposium Series
,21
(5)
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...
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TET protein inhibitors: Potential and limitations
summarizing article
open access
published version
2023
,Biomedicine & Pharmacotherapy
,166
(October)
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. ...
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Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease
original article
open access
published version
2023
,NPJ Parkinsons Disease
,9
(1)
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative ...
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Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder
original article
open access
published version
2023
,NPJ Parkinsons Disease
,9
(1)
REM sleep without atonia (RWA) is the hallmark of isolated REM sleep behavior disorder (iRBD) and is caused by neurodegeneration of brainstem structures. Previously, quantitative susceptibility mapping (QSM) was shown to ...
