Faculty of Medicine in Pilsen: Recent submissions
Now showing items 61-80 of 99
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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases
original article
open access
published version
2023
,Cancer Cell International
,23
(1)
Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...
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Blood parasites (Trypanosoma, Leucocytozoon, Haemoproteus) in the Eurasian sparrowhawk (Accipiter nisus): diversity, incidence and persistence of infection at the individual level
original article
open access
published version
2023
,Parasites & Vectors
,16
(1)
Background :A high prevalence of parasites may result from life-long persistence of infection or from high reinfection rates. We have studied blood parasites in a breeding population of the accipitrid raptor, Eurasian ...
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Genetic analysis challenges the presence of Ixodes inopinatus in Central Europe: Development of a multiplex PCR to distinguish I. inopinatus from I. ricinus
original article
open access
published version
2023
,Parasites & Vectors
,16
(1)
Background Ixodes ricinus is an important vector of several pathogens, primarily in Europe. Recently, Ixodes inopinatus was described from Spain, Portugal, and North Africa and then reported from several European countries. ...
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Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
original article
open access
published version
2023
,Diagnostics
,13
(20)
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was ...
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Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation
original article
embargoed access
accepted version
2023
,mSphere
,8
(4)
Wild birds including raptors can act as vectors of clinically relevant bacteria with antibiotic resistance. The aim of this study was to investigate the occurrence of antibiotic-resistant Escherichia coli in black kites ...
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Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
summarizing article
embargoed access
published version
2023
,Frontiers in Cellular and Infection Microbiology
,13
(July)
Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been ...
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Metodika pro detekci Paenibacillus larvae a Melissococcus plutonius pomocí PCR v reálném čase
Methods for the detection of Paenibacillus larvae and Melissococcus plutonius using real-time PCR
certified methodology
open access
published version
2023
Metodika je určena laboratořím, které se zabývají diagnostikou nákaz včel. Detekce původců moru včelího plodu (Paenibacillus larvae) a hniloby včelího plodu (Melissococcus plutonius) je nezbytná pro prevenci šíření těchto ...
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Serum Metabolite Biomarkers for Pancreatic Tumors: Neuroendocrine and Pancreatic Ductal Adenocarcinomas-A Preliminary Study
original article
open access
published version
2023
,Cancers
,15
(12)
BACKGROUND: Pancreatic cancer is the most common pancreatic solid malignancy with an aggressive clinical course and low survival rate. There are a limited number of reliable prognostic biomarkers and a need to understand ...
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DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(10)
DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, ...
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Editorial: Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria
other article
embargoed access
published version
2023
,Frontiers in Cellular and Infection Microbiology
,13
(March)
Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria - no abstract available
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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
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Survival in Lung Cancer in the Nordic Countries Through A Half Century
original article
embargoed access
published version
2023
,Clinical Epidemiology
,15
(May)
Objective: Lung cancer is often diagnosed at an advanced stage and survival has been poor, although long-term studies have been rare. We analyzed data on survival in lung cancer from Denmark, Finland, Norway, and Sweden ...
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Survival in melanoma in the nordic countries into the era of targeted and immunological therapies
original article
embargoed access
published version
2023
,European Journal of Cancer
,186
(June)
Objectives: Survival in melanoma has been increasing and the most recent interest is to observe the population-level impact of novel targeted therapies and immunotherapy. We analysed survival in melanoma from Denmark (DK), ...
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The dynamics of telomere length in primary and metastatic colorectal cancer lesions
original article
embargoed access
published version
2023
,Scientific Reports
,13
(1)
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...
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Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
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Epidemic spread of KPC-producing bacteria in the Czech Republic
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
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Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(13)
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 ...
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Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(9)
Colorectal cancer (CRC) is the third most common cancer worldwide, and metastatic CRC is a fatal disease. The CRC-affected tissues show several molecular markers that could be used as a fresh strategy to create newer methods ...
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Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers
original article
open access
published version
2023
,International Journal of Cancer
,152
(6)
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) ...
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Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements
original article
open access
published version
2023
,International Journal of Cancer
,152
(9)
Survival studies are an important indicator of the success of cancer control. We analyzed the 5-year relative survival in 23 solid cancers in Denmark, Finland, Norway and Sweden over a 50-year period (1970-2019) at the ...
