Zobrazují se záznamy 81-100 z 106

    • The dynamics of telomere length in primary and metastatic colorectal cancer lesions 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Kroupa, Michal

      ;

      Kubeček, Ondřej

      ;

      Tomášová, Kristýna

      ;

      Hanak, Petr

      ;

      Krůpová, Markéta

      ;

      Červená, Klára

      ;

      Šišková, Anna

      ;

      Rosendorf, Jáchym

      ;

      Hošek, Petr

      ;

      Vodičková, Ludmila

      ;

      Vodička, Pavel

      ;

      Liška, Václav

      ;

      John, Stanislav

      ;

      Vymetálková, Veronika

      ;

      Petera, Jiří

      2023

      ,

      Scientific Reports

      ,

      13

      (1)

      Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...

    • Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases 

      abstrakt v konferenčním sborníku

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Študentová, Vendula

      ;

      Sudová, Vendula

      ;

      Bitar, Ibrahim

      ;

      Pašková, Veronika

      ;

      Moravec, Jiří

      ;

      Pompach, Petr

      ;

      Volný, Michael

      ;

      Novák, Petr

      ;

      Hrabák, Jaroslav

      2022

      ,

      Czech Chemical Society Symposium Series

      ,

      20

      (6)

      The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

    • Epidemic spread of KPC-producing bacteria in the Czech Republic 

      abstrakt v konferenčním sborníku

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Kraftová, Lucie

      ;

      Finianos, Marc

      ;

      Heringová, Vendula

      ;

      Chudějová, Kateřina

      ;

      Jakubů, Vladislav

      ;

      Žemličková, Helena

      ;

      Costas, Papagiannitsis

      ;

      Bitar, Ibrahim

      ;

      Hrabák, Jaroslav

      2022

      ,

      Czech Chemical Society Symposium Series

      ,

      20

      (6)

      Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...

    • Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Suchá, Martina

      ;

      Benediktová, Simona

      ;

      Tichánek, Filip

      ;

      Jedlička, Jan

      ;

      Kápl, Štěpán

      ;

      Jelínková, Dana

      ;

      Purkartová, Zdeňka

      ;

      Tůma, Jan

      ;

      Kuncová, Jitka

      ;

      Cendelín, Jan

      2023

      ,

      International Journal of Molecular Sciences

      ,

      24

      (13)

      Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 ...

    • Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Kasi, Phanindra Babu

      ;

      Mallela, Venkata Ramana

      ;

      Ambrożkiewicz, Filip

      ;

      Trailin, Andriy

      ;

      Liška, Václav

      ;

      Hemminki, Kari Jussi

      2023

      ,

      International Journal of Molecular Sciences

      ,

      24

      (9)

      Colorectal cancer (CRC) is the third most common cancer worldwide, and metastatic CRC is a fatal disease. The CRC-affected tissues show several molecular markers that could be used as a fresh strategy to create newer methods ...

    • Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Hemminki, Kari Jussi

      ;

      Sundquist, Kristina

      ;

      Sundquist, Jan

      ;

      Foersti, Asta

      ;

      Liška, Václav

      ;

      Hemminki, Akseli

      ;

      Li, Xinjun

      2023

      ,

      International Journal of Cancer

      ,

      152

      (6)

      Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) ...

    • Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Hemminki, Kari Jussi

      ;

      Försti, Asta

      ;

      Liška, Václav

      ;

      Kanerva, Anna

      ;

      Hemminki, Otto

      ;

      Hemminki, Akseli

      2023

      ,

      International Journal of Cancer

      ,

      152

      (9)

      Survival studies are an important indicator of the success of cancer control. We analyzed the 5-year relative survival in 23 solid cancers in Denmark, Finland, Norway and Sweden over a 50-year period (1970-2019) at the ...

    • O čem také přemýšlejí naši medici. Sborník studentských prací (2023) 

      Thoughts of medical students. Collection of written projects (2023)

      sborník

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Vevera, Jan

      ;

      Pišl, Vojtěch

      ;

      Fridrich, Dominik

      ;

      Miloschewská, Natalie

      ;

      Bednářová, Sofie

      ;

      Bernklauová, Adriana

      ;

      Brejníková, Laura

      ;

      El Mahmoudi, Nadia

      ;

      Franková, Barbora

      ;

      Lásková, Lucie

      ;

      Loukotová, Adéla

      ;

      Malá, Nicole

      ;

      Manten, Theresa

      ;

      Pennartz, Sebastian

      ;

      Randa, Tomáš

      ;

      Salteri, Myrto Zoi

      ;

      Siebold, Patricia Sophie

      ;

      Vulliet, Lison

      2023

      ,

      Plzeň

      ,

      Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy

      Výbor nejlepších esejí, které odevzdali studenti Lékařské fakulty Univerzity Karlovy v Plzni v akademickém roce 2022/2023 v rámci předmětu Lékařská psychologie a etika.

    • Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic 

      původní článek

      embargo

      postprint

      Creative Commons License Icon

      Creative Commons BY Icon

      Mattioni Marchetti, Vittoria

      ;

      Kraftová, Lucie

      ;

      Finianos, Marc

      ;

      Sourenian-Samuelian, Tsolaire

      ;

      Hrabák, Jaroslav

      ;

      Bitar, Ibrahim

      2023

      ,

      Microbiology spectrum

      ,

      11

      (3)

      Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) Enterobacterales is reduced due to the emergence of FOS resistance. The copresence of ...

    • The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips 

      původní článek

      omezený přístup

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Dvořák, Josef

      ;

      Nováková, Jana

      ;

      Kraftová, Lucie

      ;

      Heringová, Vendula

      ;

      Matějovič, Martin

      ;

      Raděj, Jaroslav

      ;

      Karvunidis, Thomas

      ;

      Horák, Jan

      ;

      Královcová, Marcela

      ;

      Hrabák, Jaroslav

      ;

      Kalaninová, Zuzana

      ;

      Volný, Michael

      ;

      Novák, Petr

      ;

      Pompach, Petr

      2023

      ,

      Clinical Proteomics

      ,

      20

      (1)

      Background: Sepsis is a common worldwide health condition with high mortality. It is caused by a dysregulated immune response to the pathogen. Severe infections resulting in sepsis can be also determined by monitoring ...

    • Unicentric form of Castleman´s disease, pitfalls of diagnosis and surgical treatment 

      přehledový článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Moláček, Jiří

      ;

      Třeška, Vladislav

      ;

      Skalický, Tomáš

      ;

      Vodička, Josef

      ;

      Ferda, Jiří

      ;

      Ferdová, Eva

      ;

      Baxa, Jan

      ;

      Mach, Christiana

      ;

      Jungová, Alexandra

      ;

      Michal, Michael

      2023

      ,

      Frontiers in Oncology

      ,

      13

      (January)

      Background:Castleman's disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form ...

    • Red fox (Vulpes vulpes) play an important role in the propagation of tick-borne pathogens 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Creative Commons NC Icon

      Lesiczka, Paulina Maria

      ;

      Rudenko, Natalia

      ;

      Golovchenko, Maryna

      ;

      Juránková, Jana

      ;

      Daněk, Ondřej

      ;

      Modrý, David

      ;

      Hrazdilová, Kristýna

      2023

      ,

      Ticks and Tick-Borne Diseases

      ,

      14

      (1)

      The red fox (Vulpes vulpes) is the most widespread free-living carnivore in the world. Over the years, foxes have been recognized as hosts for a number of tick-borne pathogens. However, their role as reservoirs for zoonotic ...

    • The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Creative Commons NC Icon

      Reslan, Lina

      ;

      Youssef, Nour

      ;

      Boutros, Celina F.

      ;

      Assaf-Casals, Aia

      ;

      Fayad, Danielle

      ;

      Khafaja, Sarah

      ;

      Akl, Fata

      ;

      Finianos, Marc

      ;

      Rizk, Amena A.

      ;

      Shaker, Rouba

      ;

      Zaghlout, Alissar

      ;

      Lteif, Mireille

      ;

      El Hafi, Bassam

      ;

      Moumneh, Mohammad Bahij

      ;

      Feghali, Rita

      ;

      Ghanem, Soha

      ;

      Jisr, Tamima

      ;

      Karayakoupoglou, Gilbert

      ;

      Naboulsi, Malak

      ;

      Hamze, Monzer

      ;

      Samad, Salam

      ;

      Khoury, Elie

      ;

      Sarraf, Ricardo

      ;

      Osman, Marwan

      ;

      Raad, Elie Bou

      ;

      El Amin, Hadi

      ;

      Abadi, Ibrahim

      ;

      Abdo, Hicham

      ;

      Chedid, Marwan

      ;

      Chamseddine, Fatima

      ;

      Barakat, Angelique

      ;

      Houmani, Mohammad

      ;

      Haddad, Antoine

      ;

      Nour, Georges Abdel

      ;

      Mokhbat, Jacques E.

      ;

      Daoud, Ziad

      ;

      El-Zaatari, Mohamad

      ;

      Sokhn, Elie Salem

      ;

      Ghosn, Nada

      ;

      Ammar, Walid

      ;

      Hamadeh, Randa

      ;

      Matar, Ghassan M.

      ;

      Araj, George F.

      ;

      Dbaibo, Ghassan S.

      2022

      ,

      Expert Review of Vaccines

      ,

      21

      (12)

      BackgroundThe impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital ...

    • Range of metastrongylids (superfamily Metastrongyloidea) of public health and veterinary concern present in livers of the endemic lizard Gallotia galloti of Tenerife, Canary Islands, Spain 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Izquierdo-Rodriguez, Elena

      ;

      Anettova, Lucia

      ;

      Hrazdilová, Kristýna

      ;

      Foronda, Pilar

      ;

      Modry, David

      2023

      ,

      Parasites & Vectors

      ,

      16

      (1)

      Background Endemic lizards of the genus Gallotia are of high ecological value to the terrestrial ecosystem of the archipelago of the Canary Islands, being potent seed spreaders as well as an important component of the diet ...

    • Distant genetic variants of Anaplasma phagocytophilum from Ixodes ricinus attached to people 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Lesiczka, Paulina Maria

      ;

      Hrazdilová, Kristýna

      ;

      Hönig, Václav

      ;

      Modrý, David

      ;

      Zurek, Ludek

      2023

      ,

      Parasites & Vectors

      ,

      16

      (1)

      Background: Although the tick-borne pathogen Anaplasma phagocytophilum is currently described as a single species, studies using genetic markers can distinguish groups of variants associated with different hosts, pathogenicity, ...

    • Whole Genome-Based Characterization of Multidrug Resistant Enterobacter and Klebsiella aerogenes Isolates from Lebanon 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Merhi, Georgi

      ;

      Amayri, Sara

      ;

      Bitar, Ibrahim

      ;

      Araj, George F

      ;

      Tokajian, Sima

      2023

      ,

      Microbiology spectrum

      ,

      11

      (1)

      Enterobacter spp. and Klebsiella aerogenes are rod-shaped Gram-negative opportunistic pathogens. This study aimed at the molecular and genomic characterization of multidrug resistant Enterobacter spp. and K. aerogenes ...

    • Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report 

      kazuistika

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Liška, Jan

      ;

      Lišková, Veronika

      ;

      Trčka, Ondřej

      ;

      Ondič, Ondrej

      ;

      Hauer, Lukáš

      ;

      Baxa, Jan

      ;

      Kacerovská, Denisa

      2022

      ,

      Biomedical Papers

      ,

      166

      (4)

      Background: Paraneoplastic pemphigus (PNP) in the oral cavity is a rare variant of blistering pemphigus disease closely associated with mostly malignant tumors. The diagnosis may even precede an underlying malignancy ...

    • Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Cinek, Ondřej

      ;

      Slavenko, Matvei

      ;

      Pomahačová, Renata

      ;

      Venháčová, Petra

      ;

      Petruželková, Lenka

      ;

      Škvor, Jaroslav

      ;

      Neumann, David

      ;

      Konečná, Petra

      ;

      Vosáhlo, Jan

      ;

      Kocourková, Kamila

      ;

      Strnadel, Jiří

      ;

      Průhová, Štěpánka

      ;

      Šumník, Zdeněk

      2022

      ,

      Pediatric Diabetes

      ,

      23

      (7)

      OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...

    • Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment 

      přehledový článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Rajtmajerová, Marie

      ;

      Trailin, Andriy

      ;

      Liška, Václav

      ;

      Hemminki, Kari Jussi

      ;

      Ambrożkiewicz, Filip

      2022

      ,

      Cancers

      ,

      14

      (21)

      As the current staging and grading systems are not sufficient to stratify patients for therapy and predict the outcome of the disease, there is an urgent need to understand cancer in its complexity. The mutual relationship ...

    • Gut microbiome diversity of porcine peritonitis model of sepsis 

      původní článek

      embargo

      vydavatelská verze

      Ikona Jiná licence

      Chalupová, Miroslava

      ;

      Horák, Jan

      ;

      Kramná, Lenka

      ;

      Nalos, Lukáš

      ;

      Štengl, Milan

      ;

      Chudějová, Kateřina

      ;

      Kraftová, Lucie

      ;

      Cinek, Ondřej

      ;

      Klein, Pavel

      ;

      Matějovič, Martin

      ;

      Hrabák, Jaroslav

      2022

      ,

      Scientific Reports

      ,

      12

      (1)

      Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...