Faculty of Medicine in Pilsen: Recent submissions
Now showing items 61-80 of 106
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Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden
original article
open access
published version
2023
,Cancer
,129
(8)
BackgroundAutoimmune diseases are associated with many cancers but there is a lack of population-based studies with different autoimmune diseases that have a long follow-up. This is also true of hepatobiliary cancers, which ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
original article
open access
published version
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers
original article
open access
published version
2023
,Cancers
,15
(12)
Simple Summary Liver cancer is often used as a general term for cancers of the liver (hepatocellular carcinoma, HCC), the gallbladder, and the bile ducts. The well-known risk factors are alcohol and viral hepatitis, but ...
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Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma
original article
open access
published version
2023
,Oncology Letters
,26
(3)
Long non-coding RNAs (lncRNAs) serve an important role in cancer progression and may be used as efficient molecular biomarkers. The present study aimed to identify lncRNAs associated with the response to the receptor ...
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miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma
summarizing article
open access
published version
2024
,Non-coding RNA Research
,9
(1)
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding ...
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Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
original article
open access
published version
2023
,In Vivo
,37
(5)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...
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Branchioma with a nested/organoid morphology: molecular profiling of a distinctive potentially misleading variant and reappraisal of potential relationship to CD34-positive/Rb1-deficient tumors of the neck
original article
open access
published version
2023
,Virchows Archiv
,483
(4)
Branchioma (previously called ectopic hamartomatous thymoma, branchial anlage mixed tumor, or thymic anlage tumor) is a rare lower neck lesion with an adult male predominance and an uncertain histogenesis. Except for 4 ...
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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases
original article
open access
published version
2023
,Cancer Cell International
,23
(1)
Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...
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Blood parasites (Trypanosoma, Leucocytozoon, Haemoproteus) in the Eurasian sparrowhawk (Accipiter nisus): diversity, incidence and persistence of infection at the individual level
original article
open access
published version
2023
,Parasites & Vectors
,16
(1)
Background :A high prevalence of parasites may result from life-long persistence of infection or from high reinfection rates. We have studied blood parasites in a breeding population of the accipitrid raptor, Eurasian ...
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Genetic analysis challenges the presence of Ixodes inopinatus in Central Europe: Development of a multiplex PCR to distinguish I. inopinatus from I. ricinus
original article
open access
published version
2023
,Parasites & Vectors
,16
(1)
Background Ixodes ricinus is an important vector of several pathogens, primarily in Europe. Recently, Ixodes inopinatus was described from Spain, Portugal, and North Africa and then reported from several European countries. ...
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Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
original article
open access
published version
2023
,Diagnostics
,13
(20)
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was ...
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Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation
original article
embargoed access
accepted version
2023
,mSphere
,8
(4)
Wild birds including raptors can act as vectors of clinically relevant bacteria with antibiotic resistance. The aim of this study was to investigate the occurrence of antibiotic-resistant Escherichia coli in black kites ...
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Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
summarizing article
embargoed access
published version
2023
,Frontiers in Cellular and Infection Microbiology
,13
(July)
Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been ...
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Metodika pro detekci Paenibacillus larvae a Melissococcus plutonius pomocí PCR v reálném čase
Methods for the detection of Paenibacillus larvae and Melissococcus plutonius using real-time PCR
certified methodology
open access
published version
2023
Metodika je určena laboratořím, které se zabývají diagnostikou nákaz včel. Detekce původců moru včelího plodu (Paenibacillus larvae) a hniloby včelího plodu (Melissococcus plutonius) je nezbytná pro prevenci šíření těchto ...
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Serum Metabolite Biomarkers for Pancreatic Tumors: Neuroendocrine and Pancreatic Ductal Adenocarcinomas-A Preliminary Study
original article
open access
published version
2023
,Cancers
,15
(12)
BACKGROUND: Pancreatic cancer is the most common pancreatic solid malignancy with an aggressive clinical course and low survival rate. There are a limited number of reliable prognostic biomarkers and a need to understand ...
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DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(10)
DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, ...
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Editorial: Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria
other article
embargoed access
published version
2023
,Frontiers in Cellular and Infection Microbiology
,13
(March)
Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria - no abstract available
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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
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Survival in Lung Cancer in the Nordic Countries Through A Half Century
original article
embargoed access
published version
2023
,Clinical Epidemiology
,15
(May)
Objective: Lung cancer is often diagnosed at an advanced stage and survival has been poor, although long-term studies have been rare. We analyzed data on survival in lung cancer from Denmark, Finland, Norway, and Sweden ...
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Survival in melanoma in the nordic countries into the era of targeted and immunological therapies
original article
embargoed access
published version
2023
,European Journal of Cancer
,186
(June)
Objectives: Survival in melanoma has been increasing and the most recent interest is to observe the population-level impact of novel targeted therapies and immunotherapy. We analysed survival in melanoma from Denmark (DK), ...
