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Novel autophagy inducer inhibits hepatitis B virus S antigen secretion

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Author
Šmahelová, Zuzana
Pimková Polidarová, MarkétaORCiD Profile - 0000-0003-3116-1328WoS Profile - V-2351-2017Scopus Profile - 57212310198
Sedláček, Jindřich
Berehovska, Olena
Janovec, VáclavORCiD Profile - 0000-0002-6262-3364WoS Profile - N-7608-2017Scopus Profile - 57193086112
Adámek, Michael
Hirsch, IvanORCiD Profile - 0000-0003-1701-1438WoS Profile - R-3103-2016Scopus Profile - 56275056800
Machara, Aleš
Grantz Šašková, KláraORCiD Profile - 0000-0003-2874-5699WoS Profile - E-1931-2014Scopus Profile - 22954587000

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Publication date
2024
Published in
Czech Chemical Society Symposium Series
Publisher / Publication place
Česká společnost chemická
Volume / Issue
22 (6)
ISBN / ISSN
ISSN: 2336-7202
ISBN / ISSN
eISSN: 2336-7210
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Abstract
Chronic hepatitis B (CHB), a liver infection caused by the hepatitis B virus (HBV), affects more than 300 million people worldwide. If left untreated, CHB can progress to liver cirrhosis and hepatocellular carcinoma, resulting in over 800,000 deaths annually. While current therapies based on nucleot(s)ide analogues effectively slow disease progression and reduce viral load, they require lifelong adinistration. Pegylated interferon alpha therapy can achieve clearance in a small fraction of patients but is associated with significant side effects.
Keywords
Hepatitis B, HBsAg, chronic
Permanent link
https://hdl.handle.net/20.500.14178/2653
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