Faculty of Science: Recent submissions
Now showing items 61-80 of 310
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Enhancing Proteasome Function Through NRF1 Activation: Novel Small-Molecule Compounds for Treating Neurodegenerative Diseases
abstract in e-form
open access
submitted version
2024
The degradation of intracellular proteins is a strictly regulated process vital formaintaining cellular homeostasis and ensuring optimal functionality of the cell. Over90% of cytosolic proteins undergo degradation via the ...
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Analysis of the yeast linear plasmid mRNAs revealed unusual addition of the non-template nucleotides to their 5' ends and suggested a novel mechanism of translation initiation
abstract in e-form
open access
published version
2024
,Abstracts of papers presented at the 2024 meeting on TRANSLATIONAL CONTROL
Linear plasmids were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as archetypes of yeast linear plasmids, are peculiar in many respects. Both plasmids ...
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ADAR1 knockout leads to global deregulation of translation and to translational shutdown upon IFN-α/β treatment in human Huh7.5 hepatocytes
abstract in e-form
open access
published version
2024
,Abstracts of papers presented at the 2024 meeting on TRANSLATIONAL CONTROL
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Two pathogens in one vector
abstract in e-form
open access
accepted version
2024
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Sand flies (Diptera: Phlebotominae) are tiny hematophagous insects that play a critical role in the circulation of various pathogens. To explore pathogens interaction within their shared vector, Phlebotomus tobbi, we ...
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Modulation of Leishmania infection in sand flies by insect ́s midgut microbiota
abstract in e-form
open access
accepted version
2024
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The midgut microbiota of insect vectors has been recognized as a critical factor influencing the transmission dynamics of vector-borne pathogens1-3. Sand flies (Diptera: Phlebotominae), tiny blood ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cander: pilot study
abstract in e-form
open access
published version
2024
,26th Annual Conference of the European Society for Clinical Virology
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study focuses on analyzing the dynamics of HPV cell-free DNA (cfDNA) levels during the ...
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Trends in Healthy Life Years Between 2005 and 2019 in 31 European Countries: The Compression or Expansion of Morbidity?
original article
open access
published version
2024
,International Journal of Public Health
,69
(October)
Objectives: Our objective was to assess morbidity trends in Europe and to classify European countries based on population ageing theories: the compression, expansion and dynamic equilibrium of morbidity.Methods: The ...
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BK Polyomavirus Infection of Bladder Microvascular Endothelial Cells Leads to the Activation of the cGAS‐STING Pathway
original article
open access
published version
2024
,Journal of Medical Virology
,96
(11)
BK polyomavirus (BKPyV) infection in humans is usually asymptomatic but ultimately results in viral persistence. In immunocompromised hosts, virus reactivation can lead to nephropathy or hemorrhagic cystitis. The urinary ...
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Social Mobility of Elites in East-Central Europe in Historical Perspective
chapter in a collective monograph
open access
published version
2024
,Oldenbourg
,Walter de Gruyter GmbH
,Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century
The chapter discusses the concept of the social mobility and illustrates how historians of modern-time elites in Central and Eastern Europe coneptualize and approach social mobility in conjunction with the more conventional ...
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Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century
monograph
open access
published version
2024
,Oldenbourg
,Walter de Gruyter GmbH
Social mobility is about climbing the societal ladder, or switching to a better, more promising or rewarding position. But how does this work for those already atop or very close to it? The studies in the book explore ...
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Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and ...
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ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Cancer is associated with alterations in key cellular pathways, including the aspartate ββ-hydroxylase (ASPH) pathway, an oncogene upregulated in various carcinomas that plays a crucial role in tumor progression and ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cancer: Pilot study
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study analyses the dynamics of human papillomavirus (HPV) cell cell-free DNA (cfDNA) levels ...
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Unveiling viral diversity through wholevirome sequencing
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
In the dynamic landscape of viral metagenomics, our research focuses on whole-virome sequencing using the Novel enrichment technique of viromes protocol (NetoVir protocol, 1), which we have adapted to diverse starting ...
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Effect of the ADAR1 signalling pathway on HCV replication
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The hepatitis C virus (HCV) is a member of the Flaviviridae family, the genome of which consists of a +RNA molecule. It causes hepatitis C, which infects tens of millions of people worldwide. Although new direct direct-acting ...
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Understanding the interplay between BK polyomavirus and celular restriction factors
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The most important human polyomavirus are the Merkel cell polyomavirus, the etiological agent of 80% of Merkel cell carcinoma, JCPyV that causes progressive multifocal leukoencephalopathy and BKPyV which causes nephropathy. ...
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miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. ...
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Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Polyomaviruses (PyVs) are small double-stranded DNA viruses that occur widely in nature. Among the 14 known human PyVs, three are particularly relevant: BK Polyomavirus (BKPyV), JC polyomavirus, and Merkel cell carcinoma ...
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Relationship between yeast virus like elements and poxviruses at the transcriptional level
abstract in e-form
open access
accepted version
2024
,Czech Chemical Society Symposium Series
,22
(6)
Yeast cytoplasmic double-stranded DNA virus-like elements (VLEs, also known as linear plasmids) were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as ...
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Interactome analysis of the mouse polyomavirus large T antigen
abstract in e-form
open access
accepted version
2024
,Czech Chemical Society Symposium Series
,22
(6)
Polyomaviruses are small nonenveloped viruses that replicate in the nucleus of the host cell. The mouse polyomavirus (MPyV) large T antigen (LT) is the multifunctional protein expressed in the early phase of the viral ...
