Faculty of Science: Recent submissions
Now showing items 81-100 of 310
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Small-molecule activators of NRF1 transcriptional activity prevent protein aggregaton
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Intracellular protein aggregation causes proteotoxic stress, underlying highly debilitating neurodegenerative disorders in parallel with decreased proteasome activity.Nevertheless, under such stress conditions, the expression ...
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Novel autophagy inducer inhibits hepatitis B virus S antigen secretion
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Chronic hepatitis B (CHB), a liver infection caused by the hepatitis B virus (HBV), affects more than 300 million people worldwide. If left untreated, CHB can progress to liver cirrhosis and hepatocellular carcinoma, ...
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
original article
open access
published version
2024
,iScience
,27
(10)
DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining proteostasis in mammalian cells, enabling ...
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Proteogenomic Characterization of Pseudomonas veronii SM-20 Growing on Phenanthrene as Only Carbon and Energy Source
original article
open access
published version
2024
,Microorganisms
,12
(4)
In this study, we conducted an extensive investigation of the biodegradation capabilities and stress response of the newly isolated strain Pseudomonas veronii SM-20 in order, to assess its potential for bioremediation of ...
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The effect of aspartate β-hydroxylase inhibition on cancer immunotherapy
abstract in e-form
open access
accepted version
2024
,Neuveden
Aspartate β-hydroxylase (ASPH) is overexpressed in 70-90% of various solid tumors, contributing to tumor cell proliferation, migration, and invasion. In addition, recombinant ASPH inhibits natural killer (NK) cells, but ...
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Mitochondrial HER2 stimulates respiration and promotes tumorigenicity
original article
open access
published version
2024
,European Journal of Clinical Investigation
,54
(6)
Background: Amplification of HER2, a receptor tyrosine kinase and a breast cancer-linked oncogene, is associated with aggressive disease. HER2 protein is localised mostly at the cell membrane, but a fraction translocates ...
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Specifically Targeting Capture and Photoinactivation of Viruses through Phosphatidylcholine-Ganglioside Vesicles with Photosensitizer
original article
open access
published version
2024
,JACS Au
,4
(8)
Herein, we performed a simple virus capture and photoinactivation procedure using visible light on phosphatidylcholine vesicles. L-α-Phosphatidylcholine vesicles were enriched by viral receptors, GT1b gangliosides, and the ...
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Educational inequalities in cervical cancer screening participation in 24 European countries
original article
open access
published version
2024
,Public Health
,233
(August)
OBJECTIVES: Cervical cancer screening (CCS) is an important public health measure for early detection of cervical cancer and prevents a large proportion of cervical cancer deaths. However, participation in CCS is relatively ...
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Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation
abstract in conference proceedings
open access
accepted version
2024
,Hoboken
,Wiley-VCH
,European Journal of Immunology
,54
(S1)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces ...
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The Marital Fertility of Men and Women in Czechia before the First Demographic Transition and in the Current Population
original article
open access
published version
2024
,Demografie
,66
(2)
The aim of this study is to analyse the changes in the marital fertility of men and women in Czechia before the first demographic transition (data obtained by excerpting the parish registers of Škvorec manor in the years ...
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The fertility timing gap: the intended and real timing of childbirth
original article
open access
published version
2024
,Journal of Biosocial Science
,56
(3)
The fertility gap, which indicates the difference between the planned and actual number of children born, can be explained by the shift in parenthood to older ages and is associated with the non-attainment of one's intended ...
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Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis
original article
open access
published version
2024
,International Journal of Cancer
,155
(9)
The MRE11, RAD50, and NBN genes encode the MRN complex sensing DNA breaks and directing their repair. While carriers of biallelic germline pathogenic variants (gPV) develop rare chromosomal instability syndromes, the cancer ...
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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
original article
open access
published version
2024
,RNA
,30
(9)
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Educate, not kill: treating cancer without triggering its defenses
original article
open access
published version
2024
,Trends in Molecular Medicine
,30
(7)
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival ...
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Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms
original article
open access
published version
2024
,Frontiers in Immunology
,15
(20 March 2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the ...
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Sand fly blood meal volumes and their relation to female body weight under experimental conditions
original article
open access
published version
2024
,Parasites & Vectors
,17
(1)
Background Sand fly females require a blood meal to develop eggs. The size of the blood meal is crucial for fecundity and affects the dose of pathogens acquired by females when feeding on infected hosts or during experimental ...
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Population-specific validation and comparison of the performance of 77- and 313-variant polygenic risk scores for breast cancer risk prediction
original article
open access
published version
2024
,Cancer
,130
(17)
Background: The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets ...
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Parallel DNA/RNA NGS Using an Identical Target Enrichment Panel in the Analysis of Hereditary Cancer Predisposition
original article
open access
published version
2024
,Folia Biologica
,70
(1)
Germline DNA testing using the next-gene-ration sequencing (NGS) technology has become the analytical standard for the diagnostics of hereditary diseases, including cancer. Its increasing use places high demands on correct ...
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Nuclear patterns of phosphatidylinositol 4,5- and 3,4-bisphosphate revealed by super-resolution microscopy differ between the consecutive stages of RNA polymerase II transcription
original article
open access
published version
2024
,FEBS Journal
,291
(19)
Phosphatidylinositol phosphates are powerful signaling molecules that orchestrate signaling and direct membrane trafficking in the cytosol. Interestingly, phosphatidylinositol phosphates also localize within the membrane-less ...
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STING regulation in polyomavirus infections
abstract in e-form
open access
published version
2024
,Itálie
,Gianni Cinello, Lithostampa SrL, Udine
,ICGEB DNA Tumour Virus Meeting
Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses ...
