Faculty of Medicine in Pilsen: Recent submissions
Now showing items 81-100 of 106
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The dynamics of telomere length in primary and metastatic colorectal cancer lesions
original article
embargoed access
published version
2023
,Scientific Reports
,13
(1)
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...
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Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
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Epidemic spread of KPC-producing bacteria in the Czech Republic
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
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Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(13)
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 ...
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Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(9)
Colorectal cancer (CRC) is the third most common cancer worldwide, and metastatic CRC is a fatal disease. The CRC-affected tissues show several molecular markers that could be used as a fresh strategy to create newer methods ...
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Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers
original article
open access
published version
2023
,International Journal of Cancer
,152
(6)
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) ...
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Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements
original article
open access
published version
2023
,International Journal of Cancer
,152
(9)
Survival studies are an important indicator of the success of cancer control. We analyzed the 5-year relative survival in 23 solid cancers in Denmark, Finland, Norway and Sweden over a 50-year period (1970-2019) at the ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2023)
Thoughts of medical students. Collection of written projects (2023)
collection of papers
open access
published version
2023
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí, které odevzdali studenti Lékařské fakulty Univerzity Karlovy v Plzni v akademickém roce 2022/2023 v rámci předmětu Lékařská psychologie a etika.
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Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic
original article
embargoed access
accepted version
2023
,Microbiology spectrum
,11
(3)
Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) Enterobacterales is reduced due to the emergence of FOS resistance. The copresence of ...
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The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips
original article
restricted access
published version
2023
,Clinical Proteomics
,20
(1)
Background: Sepsis is a common worldwide health condition with high mortality. It is caused by a dysregulated immune response to the pathogen. Severe infections resulting in sepsis can be also determined by monitoring ...
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Unicentric form of Castleman´s disease, pitfalls of diagnosis and surgical treatment
summarizing article
open access
published version
2023
,Frontiers in Oncology
,13
(January)
Background:Castleman's disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form ...
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Red fox (Vulpes vulpes) play an important role in the propagation of tick-borne pathogens
original article
open access
published version
2023
,Ticks and Tick-Borne Diseases
,14
(1)
The red fox (Vulpes vulpes) is the most widespread free-living carnivore in the world. Over the years, foxes have been recognized as hosts for a number of tick-borne pathogens. However, their role as reservoirs for zoonotic ...
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The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
original article
open access
published version
2022
,Expert Review of Vaccines
,21
(12)
BackgroundThe impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital ...
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Range of metastrongylids (superfamily Metastrongyloidea) of public health and veterinary concern present in livers of the endemic lizard Gallotia galloti of Tenerife, Canary Islands, Spain
original article
embargoed access
published version
2023
,Parasites & Vectors
,16
(1)
Background Endemic lizards of the genus Gallotia are of high ecological value to the terrestrial ecosystem of the archipelago of the Canary Islands, being potent seed spreaders as well as an important component of the diet ...
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Distant genetic variants of Anaplasma phagocytophilum from Ixodes ricinus attached to people
original article
embargoed access
published version
2023
,Parasites & Vectors
,16
(1)
Background: Although the tick-borne pathogen Anaplasma phagocytophilum is currently described as a single species, studies using genetic markers can distinguish groups of variants associated with different hosts, pathogenicity, ...
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Whole Genome-Based Characterization of Multidrug Resistant Enterobacter and Klebsiella aerogenes Isolates from Lebanon
original article
embargoed access
published version
2023
,Microbiology spectrum
,11
(1)
Enterobacter spp. and Klebsiella aerogenes are rod-shaped Gram-negative opportunistic pathogens. This study aimed at the molecular and genomic characterization of multidrug resistant Enterobacter spp. and K. aerogenes ...
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Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report
casuistics
open access
published version
2022
,Biomedical Papers
,166
(4)
Background: Paraneoplastic pemphigus (PNP) in the oral cavity is a rare variant of blistering pemphigus disease closely associated with mostly malignant tumors. The diagnosis may even precede an underlying malignancy ...
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Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register
original article
embargoed access
published version
2022
,Pediatric Diabetes
,23
(7)
OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...
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Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment
summarizing article
embargoed access
published version
2022
,Cancers
,14
(21)
As the current staging and grading systems are not sufficient to stratify patients for therapy and predict the outcome of the disease, there is an urgent need to understand cancer in its complexity. The mutual relationship ...
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Gut microbiome diversity of porcine peritonitis model of sepsis
original article
embargoed access
published version
2022
,Scientific Reports
,12
(1)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...
