Faculty of Medicine in Pilsen: Recent submissions
Now showing items 21-40 of 99
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Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations
summarizing article
restricted access
published version
2024
,Mutagenesis
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...
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FosA3 emerging in clinical carbapenemase-producing C. freundii
original article
open access
published version
2024
,Frontiers in Cellular and Infection Microbiology
,14
(06 August 2024)
Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...
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Giant Cell Temporal Arteritis Followed by Severe Encephalopathy Induced by Immunotherapy in a Patient with Metastatic Renal Cell Carcinoma Achieving Durable Partial Response: A Case Report
casuistics
open access
published version
2024
,Case Reports in Oncology
,17
(1)
Introduction: Combined immuno-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, ...
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Steady survival improvements in soft tissue and bone sarcoma in the Nordic countries through 50 years
original article
open access
published version
2024
,Cancer Epidemiology
,29
(October)
Purpose: Sarcomas are rare cancers with many subtypes in soft tissues, bone and cartilage. International survival trends in these cancers are not well known. We present 50-year survival trends for soft tissue sarcoma (STS) ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
original article
open access
published version
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Small nucleolar RNA expression profiles: A potential prognostic biomarker for non-viral Hepatocellular carcinoma
original article
open access
published version
2024
,Non-coding RNA Research
,9
(4)
Hepatocellular carcinoma (HCC) is a challenging cancer with high mortality rates, limited predictability, and a lack of effective prognostic indicators. The relationship between small nucleolar RNAs (snoRNAs) and HCC is ...
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Critical survival periods in prostate cancer in Sweden explored by conditional survival analysis
original article
open access
published version
2024
,Cancer Medicine
,13
(7)
BackroundWe wanted to characterize conditional survival in prostate cancer (PC) in Sweden around and after 2005 when the vast increase in incidence due to the opportunistic testing for prostate specific antigen (PSA) ...
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A metric for comparison and visualization of age disparities in cancer survival
original article
restricted access
published version
2024
,Cancer Epidemiology
,91
(August)
AIMS: Diagnostic age is an important determinant of cancer survival but the methods generally used to analyze age-group-specific survival are not developed for ready visualization of survival differences. We aim at developing ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
original article
open access
published version
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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Molecular characterization of carbapenem and ceftazidime-avibactam-resistant Enterobacterales and horizontal spread of blaNDM-5 gene at a Lebanese medical center
original article
open access
published version
2024
,Frontiers in Cellular and Infection Microbiology
,14
(19 June 2024)
Introduction: In the battle against multidrug-resistant bacterial infections, ceftazidime- avibactam (CZA) stands as a pivotal defense, particularly against carbapenemresistant (CR) Gram-negative pathogens. However, the ...
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Understanding the value of monocyte distribution width (MDW) in acutely ill medical patients presenting to the emergency department: a prospective single center evaluation
original article
open access
published version
2024
,Scientific Reports
,14
(02 July 2024)
The monocyte distribution width (MDW) has emerged as a promising biomarker for accurate and early identification of patients with potentially life-threatening infections. Here we tested the diagnostic performance of MDW ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2024)
Thoughts of medical students. Collection of written projects (2024)
collection of papers
open access
published version
2024
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí napsaných studenty Lékařské fakulty Univerzity Karlovy v Plzni pro předmět Lékařská psychologie a etika v akademickém roce 2023/2024.
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Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma
original article
open access
published version
2024
,Critical Reviews in Oncology/Hematology
,200
(August)
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high morbidity and mortality rates. HCC is often detected at advanced stages leading to ineffective curative treatments. Recently, liquid biopsy ...
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Major improvement in thyroid cancer survival of elderly patients in the Nordic countries
original article
open access
published version
2024
,European Journal of Endocrinology
,190
(3)
Objectives We describe age-specific survival in thyroid cancer (TC) from Denmark, Finland, Norway, and Sweden over a 50-year period.Design Population-based survival study.Methods Relative 5-year survival data were obtained ...
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Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate
original article
open access
published version
2024
,Cancer Medicine
,13
(1)
BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer ...
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Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death
letter to the editors
open access
published version
2024
,Panminerva Medica
,66
(1)
COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...
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Learning Support Systems: A Practical Guide to E-learning at CU
uncertified methodology
open access
draft
2024
,Praha
,Univerzita Karlova, Nakladatelství Karolinum
This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...
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FosA8-producing E. coli ST131: clinical cases in Italy, February 2023
original article
open access
published version
2024
,Eurosurveillance
,29
(21)
Fosfomycin-resistant FosA8-producing Enterobacterales are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing Escherichia coli ST131 in clinical ...
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A unique human cord blood CD8(+)CD45RA(+)CD27(+)CD161(+) T-cell subset identified by flow cytometric data analysis using Seurat
original article
open access
published version
2024
,Immunology
,173
(1)
Advances in single-cell level analytical techniques, especially cytometric approaches, have led to profound innovation in biomedical research, particularly in the field of clinical immunology. This has resulted in an ...
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Spread of carbapenemase-producing Morganella spp from 2013 to 2021: a comparative genomic study
original article
open access
published version
2024
,The Lancet Microbe
,5
(6)
BACKGROUND: Morganella spp are opportunistic pathogens involved in various infections. Intrinsic resistance to multiple antibiotics (including colistin) combined with the emergence of carbapenemase producers reduces the ...
