3. Faculty of Medicine: Recent submissions
Now showing items 1-20 of 84
-
Cold, Hot, and Lethal-The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell Carcinoma
summarizing article
open access
published version
2025
,MDPI Center
,International Journal of Molecular Sciences
,26
(18)
Head and neck squamous cell carcinomas (HNSCCs) represent a diverse group of malignancies, both clinically and biologically, with human papillomavirus (HPV) infection playing a significant role. HPV-positive tumours generally ...
-
LVSP and LBBP result in similar or improved LV synchrony and hemodynamics compared to BVP
original article
open access
published version
2024
,JACC: Clinical Electrophysiology
,10
(7, Part 2)
Background The effect of left ventricular myocardial septal (LVSP) and left bundle branch pacing (LBBP) on ventricular synchrony and LV hemodynamics is poorly understood. Objective To investigate the impact of LVSP and ...
-
Neutrophil Extracellular Traps and Thrombolysis Resistance: New Insights for Targeting Therapies
original article
open access
published version
2024
,Stroke
,55
(4)
BACKGROUND: Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi ...
-
Neural Dynamics of Visual Stream Interactions During Memory-Guided Actions Investigated by Intracranial EEG
original article
open access
published version
2025
,Neuroscience Bulletin
,41
(8)
The dorsal and ventral visual streams have been considered to play distinct roles in visual processing for action: the dorsal stream is assumed to support real-time actions, while the ventral stream facilitates memory-guided ...
-
Myocardial Damage, Inflammation, Coagulation, and Platelet Activity During Catheter Ablation Using Radiofrequency and Pulsed-Field Energy
original article
open access
published version
2024
,JACC: Clinical Electrophysiology
,10
(3)
BACKGROUND: Pulsed-field ablation (PFA) represents a new, nonthermal ablation energy for the ablation of atrial fibrillation (AF). Ablation energies producing thermal injury are associated with an inflammatory response, ...
-
Significant hemolysis is present during irreversible electroporation of cardiomyocytes in vitro
original article
open access
published version
2025
,Heart Rhythm
,22
(2)
BACKGROUND: Pulsed-field ablation (PFA) of atrial fibrillation (AF) is a new method in clinical practice. Despite a favorable safety profile of PFA in AF ablation, rare cases of renal failure, probably due to hemolysis, ...
-
Periprocedural Intravascular Hemolysis During Atrial Fibrillation Ablation: A Comparison of Pulsed Field With Radiofrequency Ablation
original article
open access
published version
2024
,JACC: Clinical Electrophysiology
,10
(7, Part 2)
Background Hemolysis-related renal failure has been described after pulmonary vein isolation (PVI) with pulsed-field ablation (PFA). Objectives This study sought to compare the potential for hemolysis during PVI with PFA ...
-
Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes
original article
open access
published version
2025
,John Wiley & Sons
,Molecular Oncology
The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...
-
Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients
original article
open access
published version
2025
,Proteomics
,25
(15)
One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal ...
-
Prevalence of sexually transmitted infections in women of the Czech Republic Armed Forces: a cross-sectional pilot study
original article
open access
published version
2025
,BMJ Military Health
,171
(3)
Sexually transmitted infections (STIs) are an everlasting health issue globally. The military environment is recognised as a high-risk setting. Human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae ...
-
Sex-Linked Differences in Cardiac Atrophy After Heterotopic Heart Transplantation: No Direct Relation to the Actions of Sex Steroid Hormones
original article
open access
published version
2024
,Physiological Research
,73
(Suppl. 2)
An important complication of prolonged support of the left ventricle with an assist device when implanted in patients with heart failure is unloading-induced cardiac atrophy. Our recent study suggested that sex-linked ...
-
PROGNOSIS OF CARDIOGENIC SHOCK FOLLOWING ACUTE MYOCARDIAL INFARCTION
PROGNOSIS OF CARDIOGENIC SHOCK FOLLOWING ACUTE MYOCARDIAL INFARCTION
lecture
open access
published version
2024
-
Does it matter which part of the conduction system we capture?
lecture
open access
published version
2024
-
LVSP and LBBP result in similar or improved LV synchrony and hemodynamics compared to biventricular pacing
lecture
open access
published version
2024
-
How Does the Left Bundle Branch Area Pacing Correct Ventricular Dyssynchrony
lecture
open access
published version
2024
-
Pretreatment with dual antiplatelet therapy in acute myocardial infarction
lecture
open access
published version
2024
-
Lymfatická insuficience a tuková tkáň
abstract in e-form
open access
published version
2024
V posledních letech se objevují stále nové důkazy o tom, že lymfatický systém, resp. jeho dysfunkce, může významně ovlivňovat množství tukové tkáně. Tato přednáška se proto pokusí shrnout dosud známé aspekty souhry mezi ...
-
The use of patient-derived xenografts and patient-derived organoids in the search for new therapeutic regimens for pancreatic carcinoma. A review
summarizing article
open access
published version
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,182
(January)
Patient-derived organoids (PDOs) and xenografts (PDXs) are powerful tools for personalized medicine in pancreatic cancer (PC) research. This study explores the complementary strengths of PDOs and PDXs in terms of practicality, ...
-
Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability
original article
open access
published version
2024
,Cancer & Metabolism
,12
(September)
BackgroundHigh-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian carcinoma. It is primarily diagnosed at stage III or IV when the 5-year survival rate ranges between 20% ...
-
Infekce lidským papilomavirem (HPV) a gravidita
Human papillomavirus (HPV) infection and pregnancy
original article
open access
published version
2024
,Epidemiologie, mikrobiologie, imunologie
,73
(1)
Lidský papilomavirus (HPV) je celosvětově nejběžnější sexuálně přenosnou virovou infekcí, která může vést ke vzniku benigních lézí nebo maligních nádorů. Prevalence HPV infekce je u těhotných žen dvakrát vyšší než u ...
