2. Faculty of Medicine
Recent Submissions
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Low prevalence of neural autoantibodies in perioperative cerebrospinal fluid samples of epilepsy surgery patients: A multicenter prospective study
original article
embargoed access
published version
2024
,Epilepsia
,65
(3)
OBJECTIVE: Refractory epilepsy may have an underlying autoimmune etiology. Our aim was to assess the prevalence of neural autoantibodies in a multicenter national prospective cohort of patients with drug-resistant epilepsy ...
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Cognitive performance in distinct groups of children undergoing epilepsy surgery-a single-centre experience
original article
open access
published version
2019
,PeerJ
,7
(October)
Background. We aimed first to describe trends in cognitive performance over time in a large patient cohort (n = 203) from a single tertiary centre for paediatric epilepsy surgery over the period of 16 years divided in two ...
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Genomic insights into the spread of vancomycin- and tigecycline-resistant Enterococcus faecium ST117
original article
open access
published version
2025
,Annals of Clinical Microbiology and Antimicrobials
,24
(1)
BACKGROUND: Since the incidence of vancomycin-resistant enterococci (VRE) is increasing and treatment options remain limited, we aimed to investigate the epidemiology of vancomycin- and tigecycline-resistant enterococci ...
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Newly emerging metronidazole-resistant Clostridioides difficile PCR ribotype 955 identified in Poland, 2021 to 2023 but not in Czechia, 2012 to 2023 and Slovakia, 2015 to 2023
original article
open access
published version
2025
,Eurosurveillance
,30
(21)
BackgroundOn 29 January 2024, the European Centre for Disease Prevention and Control distributed an alert about a metronidazole-resistant Clostridioides difficile outbreak of PCR ribotype (RT) 955 in England.AimWe aimed ...
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Gut-microbiota-based ensemble model predicts prognosis of pediatric inflammatory bowel disease
original article
open access
published version
2024
,iScience
,27
(12)
Developing microbiome-based markers for pediatric inflammatory bowel disease (PIBD) is challenging. Here, we evaluated the diagnostic and prognostic potential of the gut microbiome in PIBD through a case-control study and ...
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Auer rod-positive acute leukemia with predominantly lymphoid immunophenotype: Report on 11 cases and review of literature
original article
open access
published version
2025
,Pediatric Blood and Cancer
,72
(1)
BACKGROUND: Auer rods (AuRs) are prominent intracellular structures found almost exclusively in myeloid cell malignancies, such as acute myeloid leukemia (AML), chronic and juvenile myelomonocytic leukemia and myelodysplastic ...
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Clostridioides difficile infections were predominantly driven by fluoroquinolone-resistant Clostridioides difficile ribotypes 176 and 001 in Slovakia in 2018-2019
original article
open access
published version
2023
,International Journal of Antimicrobial Agents
,62
(July)
AIMS: We aimed to investigate Clostridioides difficile (CDI) epidemiology in Slovakian hospitals after the emergence of ribotype 176 (027-like) in 2016. METHODS: Between 2018 and 2019, the ECDC CDI surveillance protocol ...
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The Composition of The Gut Virome is Associated with the Later Development of Coeliac Disease: Results of A Prospective Follow-Up of Two Neonatal Cohorts
abstract in conference proceedings
open access
published version
2024
,Praha
,Česká společnost chemická
,NIVB Meeting 2024
,22
(6)
Celiac disease (CD) develops in only a tiny fraction ofindividuals who carry susceptible HLA genotypes andconsume gluten. This has prompted the search forenvironmental triggers or accelerators, including the realm ofviruses. ...
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Bacterial contamination in public transport during COVID-19 pandemic: Characterization of an unusual Staphylococcus aureus isolate tolerant to vancomycin
original article
open access
published version
2025
,Ecotoxicology and Environmental Safety
,289
(January)
Public transport represents a potential site for the transmission of resistant pathogens due to the rapid movement of large numbers of people. This study aimed to investigate the bacterial contamination of frequently touched ...
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Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters
original article
open access
accepted version
2024
,Antimicrobial Resistance and Infection Control
,13
(1)
BACKGROUND: Multidrug-resistant (MDR) bacteria pose a significant challenge to the treatment of infectious diseases. Of particular concern are members of the Klebsiella pneumoniae species complex (KpSC), which are frequently ...
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Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability
original article
open access
published version
2024
,Cancer & Metabolism
,12
(September)
BackgroundHigh-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian carcinoma. It is primarily diagnosed at stage III or IV when the 5-year survival rate ranges between 20% ...
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Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
original article
open access
published version
2024
,Journal of Molecular Medicine
,102
(11)
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma, and caused by variants in the adaptor-related protein ...
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Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients
original article
open access
published version
2024
,Molecular Cancer
,23
(1)
BACKGROUND: The BCR::ABL1 is a hallmark of chronic myeloid leukemia (CML) and is also found in acute lymphoblastic leukemia (ALL). Most genomic breaks on the BCR side occur in two regions - Major and minor - leading to ...
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
original article
open access
published version
2024
,Cancer Letters
,605
(November)
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase ...
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Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis
original article
open access
published version
2024
,Annals of the Rheumatic Diseases
,83
(11)
OBJECTIVES: B-cell depletion time after rituximab (RTX) treatment is prolonged in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with other autoimmune diseases. We investigated central and ...
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Tviblindi algorithm identifies branching developmental trajectories of human B-cell development and describes abnormalities in RAG-1 and WAS patients
original article
open access
published version
2024
,European Journal of Immunology
,54
(12)
Detailed knowledge of human B-cell development is crucial for the proper interpretation of inborn errors of immunity and malignant diseases. It is of interest to understand the kinetics of protein expression changes during ...
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Adenotonsillar pathology in mucopolysaccharidoses - lysosomal storage predominates in paracortical CD63+ cells
original article
open access
published version
2024
,Virchows Archiv
,484
(1)
Despite the adenoids are regularly removed in patients with mucopolysaccharidoses (MPS), the underlying tissue and cellular pathologies remain understudied. We characterized an (immuno)histopathologic and ultrastructural ...
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Using patterns of shared taxa to infer bacterial dispersal in human living environment in urban and rural areas
original article
open access
published version
2024
,Applied and Environmental Microbiology
,90
(10)
Contact with environmental microbial communities primes the human immune system. Factors determining the distribution of microorganisms, such as dispersal, are thus important for human health. Here, we used the relative ...
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Educational inequalities in cervical cancer screening participation in 24 European countries
original article
open access
published version
2024
,Public Health
,233
(August)
OBJECTIVES: Cervical cancer screening (CCS) is an important public health measure for early detection of cervical cancer and prevents a large proportion of cervical cancer deaths. However, participation in CCS is relatively ...
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Correlation of genotype, phenotype and mitochondrial metabolism of patients with Friedreich's ataxia with the aim of implementing innovative therapies
poster
restricted access
accepted version
2022
Title: Presentation of a cohort of 40 Czech and Slovak patients with Friedreich's ataxia with the aim of introducing innovative therapiesBackground and objectives: Friedreich's ataxia (FA) is an autosomal recessive inherited ...
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