Unveiling the complexity of pml nuclear bodies: identification of novel PML isoforms

Abstract

Promyeloctic leukemia protein (PML) provides structural scaffolding within multiprotein, membraneless organelles known as PML nuclear bodies. Originally discovered as a tumor suppressor, PML is associated with diverse cellular regulatory processes and immune signalling. Intriguingly, the activity of PML is context-dependent, varying with intra- and extracellular environment. While the broad spectrum of identified interacting partners suggests potential modes of action, the molecular mechanisms underlying the diverse functions of PML nuclear bodies remain incompletely understood. Emerging evidence indicates that individual splicing variants of PML are crucial factors affecting their composition and functions, opening new perspectives in PML nuclear body reseach..