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Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma

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Author
Shetti, Dattatrya
Mallela, Venkata RamanaORCiD Profile - 0000-0001-9664-481XWoS Profile - JJE-1216-2023Scopus Profile - 57211855900
Ye, Wenjing
Sharif Bagheri, Mahyar
Ambrożkiewicz, FilipORCiD Profile - 0000-0001-6850-780XScopus Profile - 56964276200
Trailin, AndriyORCiD Profile - 0000-0001-8888-0759Scopus Profile - 6507189062
Liška, VáclavORCiD Profile - 0000-0002-5226-0280WoS Profile - Q-4402-2017Scopus Profile - 8705914800
Hemminki, Kari JussiORCiD Profile - 0000-0002-2769-3316

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Publication date
2024
Published in
Critical Reviews in Oncology/Hematology
Volume / Issue
200 (August)
ISBN / ISSN
ISSN: 1040-8428
ISBN / ISSN
eISSN: 1879-0461
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  • Faculty of Medicine in Pilsen

This publication has a published version with DOI 10.1016/j.critrevonc.2024.104391

Abstract
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high morbidity and mortality rates. HCC is often detected at advanced stages leading to ineffective curative treatments. Recently, liquid biopsy has emerged as a non-invasive method to identify highly specific HCC biomarkers in bodily fluids such as blood, serum, urine, and saliva. Circulating cell-free nucleic acids (cfNAs), particularly cell-free DNA (cfDNA) and cell-free RNA (cfRNA), have become promising candidates for biomarkers in liquid biopsy applications. While cfDNA presented significant challenges, researchers have turned their attention to cfRNA, which can be efficiently identified through various methods and is considered a potential biomarker for cancer diagnosis and prognosis. This review primarily focuses on studies related to detecting various cfRNA in body fluids as biomarkers. The aim is to provide a summary of available information to assist researchers in their investigations and the development of new diagnostic and prognostic tools.
Keywords
Biomarker, Diagnostic, Hepatocellular carcinoma, Liquid biopsy, Prognostic, cell-free RNA
Permanent link
https://hdl.handle.net/20.500.14178/2550
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WOS:001251387100001
SCOPUS:2-s2.0-85194829527
PUBMED:38795877
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Full text of this result is licensed under: Creative Commons Uveďte původ 4.0 International

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