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DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway

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Author
Huerfano Meneses, SandraORCiD Profile - 0000-0001-5221-3014WoS Profile - G-8469-2013Scopus Profile - 6506988916
Bruštíková, KateřinaWoS Profile - HLX-3084-2023Scopus Profile - 57200960906
Rjabčenko, BorisORCiD Profile - 0000-0001-7076-256XWoS Profile - U-8964-2017Scopus Profile - 36142246600
Šroller, VojtěchORCiD Profile - 0000-0003-1534-6007WoS Profile - Q-1098-2017Scopus Profile - 23135496600
Forstová, JitkaORCiD Profile - 0000-0003-0219-506XWoS Profile - L-7328-2017Scopus Profile - 6701385419
Kenes Group

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Publication date
2024
Published in
TOLL 2024 Road to translation
Publisher / Publication place
(Nizozemsko)
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Abstract
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed patients leads to severe disease. Recently, it has been suggested that moderate innate immune responses in reservoir cells contribute to viral persistence. For BK polyomavirus (BKPyV), cells from the urinary tract are thought to act as viral reservoirs.Here, we investigated the potential role of the cGAS-STING signalling pathway in the interferon (IFN) responses launched by primary microvascular endothelial cells from bladder (HMVECs bd) in response to BKPyV infection.
Keywords
BKPyV, cGAS, STING, interferon
Permanent link
https://hdl.handle.net/20.500.14178/2424
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Full text of this result is licensed under: Creative Commons Uveďte původ 4.0 International

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