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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunities

dc.contributor.authorRašková, Magdalena
dc.contributor.authorLacina, Lukáš
dc.contributor.authorKejík, Zdeněk
dc.contributor.authorVenhauerová, Anna
dc.contributor.authorSkaličková, Markéta
dc.contributor.authorKolář, Michal
dc.contributor.authorJakubek, Milan
dc.contributor.authorRösel, Daniel
dc.contributor.authorSmetana, Karel
dc.contributor.authorBrábek, Jan
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/20.500.14178/1804
dc.description.abstractInterleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-κB) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.3390/cells11223698
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleThe Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunitiesen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2025-01-15T10:11:51Z
dc.subject.keywordIL-6en
dc.subject.keywordcanceren
dc.subject.keywordmetastasisen
dc.identifier.eissn2073-4409
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5102
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM/EF/EF16_019/0000785
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/FN/V-FN/V-VFN
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM/OP VVV/CZ.02.1.01/0.0/0.0/16_019/0000785
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM/LM/LM2018133
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-08-00407
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU22-D-136
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-08-00407
dc.date.embargoStartDate2025-01-15
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/cells11223698
dc.identifier.utWos000887160100001
dc.identifier.eidScopus2-s2.0-85142425788
dc.identifier.obd618890
dc.identifier.rivRIV/00064165:_____/22:10451231
dc.identifier.rivRIV/00216208:11110/22:10451231
dc.identifier.rivRIV/00216208:11310/22:10451231
dc.identifier.pubmed36429126
dc.subject.rivPrimary30000::30200::30204
dc.subject.rivSecondary10000::10600
dc.subject.rivSecondary30000::30100::30106
dcterms.isPartOf.nameCells
dcterms.isPartOf.issn2073-4409
dcterms.isPartOf.journalYear2022
dcterms.isPartOf.journalVolume11
dcterms.isPartOf.journalIssue22
uk.faculty.primaryId115
uk.faculty.primaryNamePřírodovědecká fakultacs
uk.faculty.primaryNameFaculty of Scienceen
uk.faculty.secondaryId108
uk.faculty.secondaryId53
uk.faculty.secondaryName1. lékařská fakultacs
uk.faculty.secondaryNameFirst Faculty of Medicineen
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazecs
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazeen
uk.department.primaryId1035
uk.department.primaryNameKatedra buněčné biologiecs
uk.department.primaryNameDepartment of Cell Biologyen
uk.department.secondaryId1503
uk.department.secondaryId1522
uk.department.secondaryId1488
uk.department.secondaryId5000002589
uk.department.secondaryId100025448551
uk.department.secondaryNameDermatovenerologická klinika 1. LF UK a VFNcs
uk.department.secondaryNameDepartment of Dermatology and Venereologyen
uk.department.secondaryNameKlinika pediatrie a dědičných poruch metabolismu 1. LF a VFNcs
uk.department.secondaryNameDepartment of Paediatrics and Inherited Metabolic Disorders 1. LF UK a VFNen
uk.department.secondaryNameAnatomický ústav 1. LF UKcs
uk.department.secondaryNameInstitute of Anatomyen
uk.department.secondaryNameDermatovenerologická klinika 1.LF a VFNcs
uk.department.secondaryNameDermatovenerologická klinika 1.LF a VFNen
uk.department.secondaryNameBIOCEV 1. lékařské fakultycs
uk.department.secondaryNameBIOCEV of the 1st Faculty of Medicineen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::přehledový článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::summarizing articleen
dc.type.obdHierarchyCode73::152::205en
uk.displayTitleThe Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunitiesen


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