Lékařská fakulta v Plzni
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Poslední příspěvky
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
původní článek
open access
vydavatelská verze
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
původní článek
open access
vydavatelská verze
2024
,Blood Cancer Journal
,14
(1)
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...
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Survival improvements in esophageal and gastric cancers in the Nordic countries favor younger patients
původní článek
open access
vydavatelská verze
2024
,Cancer Medicine
,13
(15)
Esophageal cancer (EC) and gastric cancer (GC) are fatal cancers with a relatively late age of onset. Age is a negative risk factor for survival in many cancers and our aim was to analyze age-specific survival in EC and ...
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Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century
původní článek
open access
vydavatelská verze
2024
,Cancer Medicine
,13
(1)
Background: Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies ...
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Survival in Elderly Ovarian Cancer Remains Challenging in the Nordic Countries
původní článek
open access
vydavatelská verze
2024
,Cancers
,16
(12)
BACKGROUND: Despite treatment having improved through intensive surgical procedures and chemotherapy-and more recently, targeted therapies-ovarian cancer is the most fatal female cancer. As such, we wanted to analyze ...
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Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis
kazuistika
open access
vydavatelská verze
2024
,Psoriasis
,14
(23 September 2024)
The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition ...
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Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations
přehledový článek
omezený přístup
vydavatelská verze
2024
,Mutagenesis
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...
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FosA3 emerging in clinical carbapenemase-producing C. freundii
původní článek
open access
vydavatelská verze
2024
,Frontiers in Cellular and Infection Microbiology
,14
(06 August 2024)
Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...
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Giant Cell Temporal Arteritis Followed by Severe Encephalopathy Induced by Immunotherapy in a Patient with Metastatic Renal Cell Carcinoma Achieving Durable Partial Response: A Case Report
kazuistika
open access
vydavatelská verze
2024
,Case Reports in Oncology
,17
(1)
Introduction: Combined immuno-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, ...
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Steady survival improvements in soft tissue and bone sarcoma in the Nordic countries through 50 years
původní článek
open access
vydavatelská verze
2024
,Cancer Epidemiology
,29
(October)
Purpose: Sarcomas are rare cancers with many subtypes in soft tissues, bone and cartilage. International survival trends in these cancers are not well known. We present 50-year survival trends for soft tissue sarcoma (STS) ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
původní článek
open access
vydavatelská verze
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Small nucleolar RNA expression profiles: A potential prognostic biomarker for non-viral Hepatocellular carcinoma
původní článek
open access
vydavatelská verze
2024
,Non-coding RNA Research
,9
(4)
Hepatocellular carcinoma (HCC) is a challenging cancer with high mortality rates, limited predictability, and a lack of effective prognostic indicators. The relationship between small nucleolar RNAs (snoRNAs) and HCC is ...
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Critical survival periods in prostate cancer in Sweden explored by conditional survival analysis
původní článek
open access
vydavatelská verze
2024
,Cancer Medicine
,13
(7)
BackroundWe wanted to characterize conditional survival in prostate cancer (PC) in Sweden around and after 2005 when the vast increase in incidence due to the opportunistic testing for prostate specific antigen (PSA) ...
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A metric for comparison and visualization of age disparities in cancer survival
původní článek
omezený přístup
vydavatelská verze
2024
,Cancer Epidemiology
,91
(August)
AIMS: Diagnostic age is an important determinant of cancer survival but the methods generally used to analyze age-group-specific survival are not developed for ready visualization of survival differences. We aim at developing ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
původní článek
open access
vydavatelská verze
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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Molecular characterization of carbapenem and ceftazidime-avibactam-resistant Enterobacterales and horizontal spread of blaNDM-5 gene at a Lebanese medical center
původní článek
open access
vydavatelská verze
2024
,Frontiers in Cellular and Infection Microbiology
,14
(19 June 2024)
Introduction: In the battle against multidrug-resistant bacterial infections, ceftazidime- avibactam (CZA) stands as a pivotal defense, particularly against carbapenemresistant (CR) Gram-negative pathogens. However, the ...
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Understanding the value of monocyte distribution width (MDW) in acutely ill medical patients presenting to the emergency department: a prospective single center evaluation
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(02 July 2024)
The monocyte distribution width (MDW) has emerged as a promising biomarker for accurate and early identification of patients with potentially life-threatening infections. Here we tested the diagnostic performance of MDW ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2024)
Thoughts of medical students. Collection of written projects (2024)
sborník
open access
vydavatelská verze
2024
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí napsaných studenty Lékařské fakulty Univerzity Karlovy v Plzni pro předmět Lékařská psychologie a etika v akademickém roce 2023/2024.
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Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma
původní článek
open access
vydavatelská verze
2024
,Critical Reviews in Oncology/Hematology
,200
(August)
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high morbidity and mortality rates. HCC is often detected at advanced stages leading to ineffective curative treatments. Recently, liquid biopsy ...
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Major improvement in thyroid cancer survival of elderly patients in the Nordic countries
původní článek
open access
vydavatelská verze
2024
,European Journal of Endocrinology
,190
(3)
Objectives We describe age-specific survival in thyroid cancer (TC) from Denmark, Finland, Norway, and Sweden over a 50-year period.Design Population-based survival study.Methods Relative 5-year survival data were obtained ...
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