Decoding interferon regulation in BKPyV-infected bladder end othelial cells

Abstract

BK polyomavirus (BKPyV) infects approximately 80% of the human population, typically establishing persistence during childhood by replicating at low levels in the urinary tract. Low Low-level activation of innate immune responses appears to support both viral control and long long-term persistence. In immunocompromised individuals, BKPyV can cause serious complications such as BK virus virus-associated nephropathy.