Unravelling head tremor mechanisms: insights from speech analysis in essential tremor and cervical dystonia

Abstract

Head tremor is a common symptom in both essential tremor (ET) and cervical dystonia (CD). Distinguishing between these two conditions can be challenging in clinical practice, particularly when head tremor is the dominant feature. Our goal was to explore the potential of speech assessment in recognizing the mechanisms of head tremor in patients with ET and CD. Objective acoustic vocal assessments of oral diadochokinesis, phonatory stability, vocal tremor, and speech timing were performed. Of the 93 patients assessed, 39 had cervical dystonia (CD) with head tremor, 38 had ET with head tremor (ET-HT), and 16 had ET with no head tremor (ET-nHT). Compared to both CD and ET-nHT, ET-HT showed irregular sequential motion rate, excessive pitch fluctuations, increased noise, and higher extent of vocal vibrato. Compared to CD, ET-HT also demonstrated slower sequential motion rate, prolonged pauses, and a slower articulation rate. Additionally, ET-HT had more pronounced vocal tremolo compared to ET-nHT. Speech assessment provided discrimination between the CD and ET-HT groups with an area under curve of 0.80. This study underscores the promising potential of speech analysis in recognizing mechanisms of head tremor in patients with ET or CD, revealing more severe and distinct speech impairments in ET-HT patients compared to those with CD.