| dc.contributor.author | Johari, Shweta Dilip | |
| dc.contributor.author | Krausová, Kateřina | |
| dc.contributor.author | Žucha, Barbora | |
| dc.contributor.author | Madureira Trufen, Carlos Eduardo | |
| dc.contributor.author | Poláková, Ingrid | |
| dc.contributor.author | Olsen, Mark | |
| dc.contributor.author | Šmahel, Michal | |
| dc.date.accessioned | 2025-07-23T09:40:55Z | |
| dc.date.available | 2025-07-23T09:40:55Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14178/3141 | |
| dc.description.abstract | Aspartate β-hydroxylase (ASPH) contributes to carcinogenesis by promoting tumor cell proliferation, migration, and invasion. The enzymatic activity of ASPH can be inhibited by small molecule inhibitors that have been shown to have antimetastatic activity in rodent models. ASPH has also been shown to inhibit the activation of natural killer (NK) cells. Therefore, this study aimed to investigate the effect of ASPH inhibition on the induction of anti-tumor immunity and to analyze the immune cells involved. | en |
| dc.language.iso | en | |
| dc.relation.url | https://doi.org/10.2147/ITT.S530987 | |
| dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.title | Inhibition of Aspartate β-Hydroxylase Enhances Anti-Tumor Immunity | en |
| dcterms.accessRights | openAccess | |
| dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
| dc.date.updated | 2025-07-23T09:40:55Z | |
| dc.subject.keyword | cancer immunotherapy | en |
| dc.subject.keyword | ASPH | en |
| dc.subject.keyword | adaptive immunity | en |
| dc.subject.keyword | scRNA-seq | en |
| dc.subject.keyword | tumor microenvironment | en |
| dc.identifier.eissn | 2253-1556 | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//SVV260807 | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/GAUK/GAUK371921 | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
| dc.date.embargoStartDate | 2025-07-23 | |
| dc.type.obd | 73 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dc.identifier.doi | 10.2147/ITT.S530987 | |
| dc.identifier.utWos | 001526770200001 | |
| dc.identifier.obd | 667169 | |
| dc.identifier.pubmed | 40655119 | |
| dc.subject.rivPrimary | 30000::30200::30204 | |
| dc.subject.rivSecondary | 30000::30100::30102 | |
| dcterms.isPartOf.name | ImmunoTargets and Therapy | |
| dcterms.isPartOf.issn | 2253-1556 | |
| dcterms.isPartOf.journalYear | 2025 | |
| dcterms.isPartOf.journalVolume | 14 | |
| dcterms.isPartOf.journalIssue | July | |
| uk.faculty.primaryId | 115 | |
| uk.faculty.primaryName | Přírodovědecká fakulta | cs |
| uk.faculty.primaryName | Faculty of Science | en |
| uk.department.primaryId | 1034 | |
| uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
| uk.department.primaryName | Department of Genetics and Microbiology | en |
| dc.description.pageRange | 697-718 | |
| dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
| dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
| dc.type.obdHierarchyCode | 73::152::206 | en |
| uk.displayTitle | Inhibition of Aspartate β-Hydroxylase Enhances Anti-Tumor Immunity | en |
