| dc.contributor.author | Berehovska, Olena | |
| dc.contributor.author | Pimková Polidarová, Markéta | |
| dc.contributor.author | Janovec, Václav | |
| dc.contributor.author | Hirsch, Ivan | |
| dc.contributor.author | Grantz Šašková, Klára | |
| dc.date.accessioned | 2024-10-14T09:15:49Z | |
| dc.date.available | 2024-10-14T09:15:49Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14178/2658 | |
| dc.description.abstract | Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. Plasmacytoid dendritic cells (pDCs), robust producers of type I and III interferons (IFNs), 1 which are crucial for HBV clearance. However, miRNA146a, an immunosuppressive and proliferative miRNA in hepatocytes, modulates pDCs by silencing TRAF6 and IRAK1/4 proteins. | en |
| dc.language.iso | en | |
| dc.publisher | Česká společnost chemická | |
| dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.title | miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV | en |
| dcterms.accessRights | openAccess | |
| dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
| dc.date.updated | 2024-10-14T09:15:49Z | |
| dc.subject.keyword | Hepatitis B | en |
| dc.subject.keyword | virus (HBV) | en |
| dc.subject.keyword | miRNA146a | en |
| dc.identifier.eissn | 2336-7210 | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
| dc.date.embargoStartDate | 2024-10-14 | |
| dc.type.obd | 110 | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dc.identifier.obd | 653753 | |
| dc.subject.rivPrimary | 10000::10600 | |
| dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
| dcterms.isPartOf.issn | 2336-7202 | |
| dcterms.isPartOf.journalYear | 2024 | |
| dcterms.isPartOf.journalVolume | 22 | |
| dcterms.isPartOf.journalIssue | 6 | |
| uk.faculty.primaryId | 115 | |
| uk.faculty.primaryName | Přírodovědecká fakulta | cs |
| uk.faculty.primaryName | Faculty of Science | en |
| uk.department.primaryId | 1034 | |
| uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
| uk.department.primaryName | Department of Genetics and Microbiology | en |
| uk.event.name | The third annual meeting of the National Institute of Virology and Bacterology (NIVB) | |
| dc.description.pageRange | 249-249 | |
| dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v elektronické podobě | cs |
| dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in e-form | en |
| dc.type.obdHierarchyCode | 110::130::136 | en |
| uk.displayTitle | miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV | en |
