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The effect of aspartate β-hydroxylase inhibition on cancer immunotherapy

dc.contributor.authorJohari, Shweta Dilip
dc.contributor.authorKrausová, Kateřina
dc.contributor.authorŽucha, Barbora
dc.contributor.authorMadureira Trufen, Carlos Eduardo
dc.contributor.authorPoláková, Ingrid
dc.contributor.authorOlsen, Mark
dc.contributor.authorŠmahel, Michal
dc.date.accessioned2024-10-04T10:45:40Z
dc.date.available2024-10-04T10:45:40Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2644
dc.description.abstractAspartate β-hydroxylase (ASPH) is overexpressed in 70-90% of various solid tumors, contributing to tumor cell proliferation, migration, and invasion. In addition, recombinant ASPH inhibits natural killer (NK) cells, but an effect on other immune cells has not been described. Small molecule inhibitors have been developed to target tumors overexpressing ASPH. In this study, we combined ASPH inhibition with immunotherapy to enhance cancer therapy and seek out affected immune cells.en
dc.language.isoen
dc.relation.urlhttps://www.pivac-prague.cz/
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleThe effect of aspartate β-hydroxylase inhibition on cancer immunotherapyen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-10-04T10:45:40Z
dc.subject.keywordaspartate β-hydroxylaseen
dc.subject.keywordimmunotherapyen
dc.subject.keywordASPH inhibitoren
dc.subject.keywordElispot assayen
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.date.embargoStartDate2024-10-04
dc.contributor.organizerCCL-CONFERENCE CZECHOSLOVAKIA LTD.
dc.type.obd110
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.obd653499
dc.subject.rivPrimary30000::30200::30204
dcterms.isPartOf.nameNeuveden
dcterms.isPartOf.journalYear2024
uk.faculty.primaryId115
uk.faculty.primaryNamePřírodovědecká fakultacs
uk.faculty.primaryNameFaculty of Scienceen
uk.department.primaryId1034
uk.department.primaryNameKatedra genetiky a mikrobiologiecs
uk.department.primaryNameDepartment of Genetics and Microbiologyen
uk.department.secondaryId1035
uk.department.secondaryNameKatedra buněčné biologiecs
uk.department.secondaryNameDepartment of Cell Biologyen
uk.event.name23rd International Conference on Progress in Vaccination Against Cance
dc.description.pageRangenestránkováno
dc.type.obdHierarchyCsABSTRAKT::abstrakt::abstrakt v elektronické podoběcs
dc.type.obdHierarchyEnABSTRACT::abstract::abstract in e-formen
dc.type.obdHierarchyCode110::130::136en
uk.displayTitleThe effect of aspartate β-hydroxylase inhibition on cancer immunotherapyen


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