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Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation

dc.contributor.authorPimková Polidarová, Markéta
dc.contributor.authorBrázdová, Andrea
dc.contributor.authorHirsch, Ivan
dc.contributor.authorGrantz Šašková, Klára
dc.date.accessioned2024-09-11T12:15:34Z
dc.date.available2024-09-11T12:15:34Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2608
dc.description.abstractThe cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces secretion of proinflammatory cytokines by immune cells that in turn modulate antiviral and antitumoral responses. Therefore, synthetic activators of the cGAS-STING pathway, such as STING agonists, are of therapeutic interest.We have recently demonstrated that STING agonists not only trigger cytokine production in peripheral blood mononuclear cells (PBMCs) but also induce cell death of monocytes. Here we investigated the mechanisms of monocyte death in terms of apoptosis, pyroptosis and necroptosis.en
dc.language.isoen
dc.publisherWiley-VCH
dc.relation.urlhttps://doi.org/10.1002/eji.202470200
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleCharacterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activationen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2025-02-21T14:40:58Z
dc.subject.keywordSTINGen
dc.subject.keywordcGAS-STINGen
dc.subject.keywordmonocyte cellen
dc.publisher.publicationPlaceHoboken
dc.identifier.eissn1521-4141
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.date.embargoStartDate2025-02-21
dc.contributor.organizerOIC srl
dc.type.obd110
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.doi10.1002/eji.202470200
dc.identifier.utWos001364287303264
dc.identifier.obd651928
dc.subject.rivPrimary30000::30100::30102
dcterms.isPartOf.nameEuropean Journal of Immunology
dcterms.isPartOf.issn0014-2980
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume54
dcterms.isPartOf.journalIssueS1
uk.faculty.primaryId115
uk.faculty.primaryNamePřírodovědecká fakultacs
uk.faculty.primaryNameFaculty of Scienceen
uk.department.primaryId1034
uk.department.primaryNameKatedra genetiky a mikrobiologiecs
uk.department.primaryNameDepartment of Genetics and Microbiologyen
uk.event.name7th European Conference of Immunology
dc.description.pageRange1438-1438
dc.type.obdHierarchyCsABSTRAKT::abstrakt::abstrakt v konferenčním sborníkucs
dc.type.obdHierarchyEnABSTRACT::abstract::abstract in conference proceedingsen
dc.type.obdHierarchyCode110::130::462en
uk.displayTitleCharacterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activationen


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