dc.contributor.author | Pimková Polidarová, Markéta | |
dc.contributor.author | Brázdová, Andrea | |
dc.contributor.author | Hirsch, Ivan | |
dc.contributor.author | Grantz Šašková, Klára | |
dc.date.accessioned | 2024-09-11T12:15:34Z | |
dc.date.available | 2024-09-11T12:15:34Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2608 | |
dc.description.abstract | The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces secretion of proinflammatory cytokines by immune cells that in turn modulate antiviral and antitumoral responses. Therefore, synthetic activators of the cGAS-STING pathway, such as STING agonists, are of therapeutic interest.We have recently demonstrated that STING agonists not only trigger cytokine production in peripheral blood mononuclear cells (PBMCs) but also induce cell death of monocytes. Here we investigated the mechanisms of monocyte death in terms of apoptosis, pyroptosis and necroptosis. | en |
dc.language.iso | en | |
dc.publisher | Wiley-VCH | |
dc.relation.url | https://doi.org/10.1002/eji.202470200 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2025-02-21T14:40:58Z | |
dc.subject.keyword | STING | en |
dc.subject.keyword | cGAS-STING | en |
dc.subject.keyword | monocyte cell | en |
dc.publisher.publicationPlace | Hoboken | |
dc.identifier.eissn | 1521-4141 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2025-02-21 | |
dc.contributor.organizer | OIC srl | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |
dc.identifier.doi | 10.1002/eji.202470200 | |
dc.identifier.utWos | 001364287303264 | |
dc.identifier.obd | 651928 | |
dc.subject.rivPrimary | 30000::30100::30102 | |
dcterms.isPartOf.name | European Journal of Immunology | |
dcterms.isPartOf.issn | 0014-2980 | |
dcterms.isPartOf.journalYear | 2024 | |
dcterms.isPartOf.journalVolume | 54 | |
dcterms.isPartOf.journalIssue | S1 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | 7th European Conference of Immunology | |
dc.description.pageRange | 1438-1438 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation | en |