Repozitář publikační činnosti UK: Poslední příspěvky

Zobrazují se záznamy 201-220 z 1882

    • The role of aspartate beta-hydroxylase in tumors associated with human papillomaviruses 

      abstrakt v konferenčním sborníku

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      Kanwal, Madiha

      ;

      Šmahelová, Jana

      ;

      Johari, Shweta Dilip

      ;

      Poláková, Ingrid

      ;

      Žucha, Barbora

      ;

      Mark, Olsen

      ;

      Krausová, Kateřina

      ;

      Pokrývková, Barbora

      ;

      Madureira Trufen, Carlos Eduardo

      ;

      Nunvář, Jaroslav

      ;

      Šťovíčková, Eliška

      ;

      Grega, Marek

      ;

      Vencálek, Ondřej

      ;

      Koucký, Vladimír

      ;

      Maléřová, Simona

      ;

      Klozar, Jan

      ;

      Kasi, Murtaza Khan

      ;

      Tachezy, Ruth

      ;

      Šmahel, Michal

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      Aspartate beta-hydroxylase (ASPH) is a transmembrane protein that is localized in the endoplasmic reticulum. It is not produced in most normal cells, but the expression is increased in tumor cells, where it can be localized ...

    • The role of miRNA-146a in antiviral immune response to TLR9 stimulation in periferal blood mononuclear cells 

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      Berehovska, Olena

      ;

      Pimková Polidarová, Markéta

      ;

      Brázdová, Andrea

      ;

      Hirsch, Ivan

      ;

      Grantz Šašková, Klára

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      Hepatitis B virus (HBV) is a major global health threat, causing acute and chronic liver disease, leading cirrhosis, and hepatocellular carcinoma, with nearly one million deaths each year. Over 250 million people worldwide ...

    • Cell-free HPV DNA as a biomarker for the treatment response monitoring in oropharyngeal cancer patients in the Czech Republic 

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      Šmahelová, Jana

      ;

      Vojtěchová, Zuzana

      ;

      Milt, Petr

      ;

      Saláková, Martina

      ;

      Lohynská, Radka

      ;

      Lacek, Michal

      ;

      Čoček, Aleš

      ;

      Krátká, Zuzana

      ;

      Tachezy, Ruth

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      Cell-free tumor DNA (cfDNA) in liquid biopsies is a promising diagnostic and prognostic biomarker for cancers, including human papillomavirus (HPV)-driven oropharyngeal carcinoma (OPC). Monitoring cfHPV DNA dynamics in ...

    • The role of β-2-microglobulin in tumor development 

      abstrakt v konferenčním sborníku

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      Žucha, Barbora

      ;

      Poláková, Ingrid

      ;

      Piataková, Adrianna Julia

      ;

      Šmahel, Michal

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      The tumor microenvironment (TME) is a dynamic ecosystem where cancer cells interact with the immune system to either promote or inhibit tumor progression.A crucial aspect of this interaction involves the major histocompatibility ...

    • Decoding interferon regulation in BKPyV-infected bladder end othelial cells 

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      Lovtsov, Alexey

      ;

      Huerfano Meneses, Sandra

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      BK polyomavirus (BKPyV) infects approximately 80% of the human population, typically establishing persistence during childhood by replicating at low levels in the urinary tract. Low Low-level activation of innate immune ...

    • TRAF6 drives parallel innate immune responses via TLR4 and cGAS-STING during MPyV infection 

      abstrakt v konferenčním sborníku

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      Biswas, Jui

      ;

      Rjabčenko, Boris

      ;

      Horníková, Lenka

      ;

      Janovec, Václav

      ;

      Bruštíková, Kateřina

      ;

      Dejmek, Milan

      ;

      Jauce, Czech

      ;

      Huerfano Meneses, Sandra

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      Polyomaviruses are small DNA viruses linked to a range of human diseases, including cancer. The murine polyomavirus (MPyV) serves as a well-established model for exploring the biology of human polyomaviruses. MPyV activates ...

    • Cross-border Reproductive Care in Czechia: Insights from National Registry Data 

      původní článek

      open access

      vydavatelská verze

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      Volejníková, Adéla

      ;

      Šťastná, Anna

      ;

      Kocourková, Jiřina

      2025

      ,

      Bundesinstitut für Bevölkerungsforschung

      ,

      Comparative Population Studies

      ,

      50

      (16.09.2025)

      This article analyses cross-border reproductive care (CBRC) in Czechia using comprehensive data from the National Registry of Assisted Reproduction (2016-2019). It identifies the main patient source countries, highlights ...

    • Associations between psychological or biological stress indicators and gut microbiota in pregnant women – findings from a prospective longitudinal study 

      původní článek

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      Kreisinger, Jakub

      ;

      Kaňková, Šárka

      ;

      Dlouhá, Daniela

      ;

      Ullmann, Jana

      ;

      Nouzová, Kamila

      ;

      Hrbáčková, Hana

      ;

      Schmiedová, Lucie

      ;

      Takács, Lea

      2025

      ,

      BioMed Central

      ,

      BMC Microbiology

      ,

      25

      (1)

      The perinatal period has been linked with higher vulnerability to stress and symptoms of depression and anxiety, as well as with dynamic changes in the composition of maternal gut microbiota. While recent studies indicated ...

    • Investigating the impact of ADAR1 on HCV replication 

      abstrakt v konferenčním sborníku

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      Kubů, Martin

      ;

      Roučová, Kristina

      ;

      Pospíšek, Martin

      ;

      Vopálenský, Václav

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      The hepatitis C virus (HCV) is a member of the Flaviviridae family. The virus is the causative agent of hepatitis C, a disease that affects tens of millions of people worldwide. New direct direct-acting antivirals (DAAs) ...

    • Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia 

      letter to the editors

      open access

      vydavatelská verze

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      Šálek, Cyril

      ;

      Hrabovsky, Stepan

      ;

      Folber, Frantisek

      ;

      Koristek, Zdenek

      ;

      Horáček, Jan Miloš

      ;

      Froňková, Eva

      ;

      Rezková Řezníčková, Leona

      ;

      Pecherkova, Pavla

      ;

      Soukup, Petr

      ;

      Dluhosova, Barbora

      ;

      Polivkova, Vaclava

      ;

      Krizkova, Jitka

      ;

      Polakova Machova, Katerina

      ;

      Vrzalova, Zuzana

      ;

      Halamova, Hana

      ;

      Trka, Jan

      ;

      Cetkovský, Petr

      ;

      Doubek, Michael

      2025

      ,

      Haematologica

      ,

      110

      (7)

      Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable ...

    • Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions 

      původní článek

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      vydavatelská verze

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      Lamoureux, Audrey-Anne

      ;

      Fisher, Michael J

      ;

      Lemelle, Lauriane

      ;

      Pfaff, Elke

      ;

      Amir-Yazdani, Pouneh

      ;

      Kramm, Christof

      ;

      De Wilde, Bram

      ;

      Kazanowska, Bernarda

      ;

      Hutter, Caroline

      ;

      Pfister, Stefan M

      ;

      Sturm, Dominik

      ;

      Jones, David T W

      ;

      Orbach, Daniel

      ;

      Pierron, Gaëlle

      ;

      Raskin, Scott

      ;

      Drilon, Alexander

      ;

      Diamond, Eli L

      ;

      Harada, Guilherme

      ;

      Zápotocký, Michal

      ;

      Zámečník, Josef

      ;

      Krsková, Lenka

      ;

      Ellezam, Benjamin

      ;

      Weil, Alexander G

      ;

      Venne, Dominic

      ;

      Barritault, Marc

      ;

      Leblond, Pierre

      ;

      Coltin, Hallie

      ;

      Hammad, Rawan

      ;

      Tabori, Uri

      ;

      Hawkins, Cynthia

      ;

      Hansford, Jordan R

      ;

      Meyran, Deborah

      ;

      Erker, Craig

      ;

      McFadden, Kathryn

      ;

      Sato, Mariko

      ;

      Gottardo, Nicholas G

      ;

      Dholaria, Hetal

      ;

      Nørøxe, Dorte Schou

      ;

      Goto, Hiroaki

      ;

      Ziegler, David S

      ;

      Lin, Frank Y

      ;

      Parsons, Donald Williams

      ;

      Lindsay, Holly

      ;

      Wong, Tai-Tong

      ;

      Liu, Yen-Lin

      ;

      Wu, Kuo-Sheng

      ;

      Franson, Andrea T

      ;

      Hwang, Eugene

      ;

      Aguilar-Bonilla, Ana

      ;

      Cheng, Sylvia

      ;

      Cacciotti, Chantel

      ;

      Massimino, Maura

      ;

      Schiavello, Elisabetta

      ;

      Wood, Paul

      ;

      Hoffman, Lindsey M

      ;

      Cappellano, Andréa

      ;

      Lassaletta, Alvaro

      ;

      Van Damme, An

      ;

      Llort, Anna

      ;

      Gerber, Nicolas U

      ;

      Spalato Ceruso, Mariella

      ;

      Bendel, Anne E

      ;

      Skrypek, Maggie

      ;

      Hamideh, Dima

      ;

      Mushtaq, Naureen

      ;

      Walter, Andrew

      ;

      Jabado, Nada

      ;

      Alsahlawi, Aysha

      ;

      Farmer, Jean-Pierre

      ;

      Coleman, Christina

      ;

      Mueller, Sabine

      ;

      Mazewski, Claire

      ;

      Aguilera, Dolly

      ;

      Robison, Nathan J

      ;

      O'Halloran, Katrina

      ;

      Abbou, Samuel

      ;

      Berlanga, Pablo

      ;

      Geoerger, Birgit

      ;

      Øra, Ingrid

      ;

      Moertel, Christopher L

      ;

      Razis, Evangelia D

      ;

      Vernadou, Anastasia

      ;

      Ducray, François

      ;

      Bronnimann, Charlotte

      ;

      Seizeur, Romuald

      ;

      Clarke, Matthew

      ;

      Resnick, Adam C

      ;

      Alves, Mélanie

      ;

      Jones, Chris

      ;

      Doz, François

      ;

      Laetsch, Theodore W

      ;

      Perreault, Sébastien

      2025

      ,

      American Association for Cancer Research

      ,

      Clinical Cancer Research

      ,

      31

      (3)

      PURPOSE: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. EXPERIMENTAL DESIGN: We conducted an international retrospective cohort ...

    • Souhrnná výzkumná zpráva projektu: Multiplatformní aplikace pro výuku a testování v hudební výchově, TAČR – TQ01000014 

      Summary research report of the project: Multiplatform applications for teaching and testing in music education

      souhrnná výzkumná zpráva

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      draft

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      Nedělka, Michal

      ;

      Bělohlávková, Petra

      ;

      Kmentová, Milena

      ;

      Kucharská, Anna

      ;

      Raušer, Jaroslav

      2025

      Dokumentace obsahující Závěrečnou zprávu o postupu prací a dosažených výsledků - včetně příloh:1) Informace o otevřeném přístupu k výsledkům a datům;2) Evaluace hodin práce s aplikací;3 a 4) Dataset odpovědí studentů - ...

    • Unveiling the complexity of pml nuclear bodies: identification of novel PML isoforms 

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      Anderová, Karolína

      ;

      Horníková, Lenka

      ;

      Šroller, Vojtěch

      ;

      Rjabčenko, Boris

      ;

      Pánek, Dalibor

      ;

      Andrikopoulos, Prokopios

      ;

      Zahradník, Jiří

      ;

      Forstová, Jitka

      ;

      Huerfano Meneses, Sandra

      2025

      ,

      Praha

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      23

      (4)

      Promyeloctic leukemia protein (PML) provides structural scaffolding within multiprotein, membraneless organelles known as PML nuclear bodies. Originally discovered as a tumor suppressor, PML is associated with diverse ...

    • Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors 

      původní článek

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      vydavatelská verze

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      Daumová, Lenka

      ;

      Manakov, Dmitry

      ;

      Petrák, Jiří

      ;

      Sovilj, Dana

      ;

      Běhounek, Matěj

      ;

      Andera, Ladislav

      ;

      Vít, Ondřej

      ;

      Součková, Olga

      ;

      Havránek, Ondřej

      ;

      Dolníková, Alexandra

      ;

      Renešová, Nicol

      ;

      Tušková, Liliana

      ;

      Winkowska, Lucie

      ;

      Bettazová, Nardjas

      ;

      Kupcová, Kristýna

      ;

      Hubálek Kalbáčová, Marie

      ;

      Sikorová, Miriama

      ;

      Trněný, Marek

      ;

      Klener, Pavel

      2025

      ,

      Cell Death Discovery

      ,

      11

      (1)

      A large body of evidence suggests that hypoxia drives aggressive molecular features of malignant cells irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common hematologic malignancies characterized by ...

    • Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma 

      původní článek

      open access

      vydavatelská verze

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      Obr, Ales

      ;

      Maláriková, Diana

      ;

      Kriegova, Eva

      ;

      Urbankova, Helena

      ;

      Zemanová, Zuzana

      ;

      Manakova, Jirina

      ;

      Petrackova, Anna

      ;

      Vatolikova, Michaela

      ;

      Berková, Adéla

      ;

      Forsterová, Kristina

      ;

      Furst, Tomas

      ;

      Hruskova, Andrea

      ;

      Flodr, Patrik

      ;

      Hanackova, Veronika

      ;

      Prochazka, Vit

      ;

      Papajik, Tomas

      ;

      Trněný, Marek

      ;

      Klener, Pavel

      2025

      ,

      North Shore-Long Island Jewish Research Institute

      ,

      Molecular Medicine

      ,

      31

      (1)

      Background: Previous studies have suggested that, after acquisition of t(11;14), mantle cell lymphoma (MCL) pathogenesis may proceed via several different genetic second hits, which may shape different mutational profiles ...

    • First Steps in the Development of a Multilevel Model of Resilience for the Czech Attitude Barometer Panel Survey (2024–2027) 

      původní článek

      open access

      vydavatelská verze

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      Lyon, Pat

      ;

      Lupač, Petr

      2025

      ,

      Karolinum

      ,

      Acta Universitatis Carolinae. Philosophica et Historica

      ,

      2025

      (2022/2)

      This paper presents a multilevel model of resilience for testing with the Czech Attitude Barometer panel survey (CAB, 2024-2027). Individual resilience is defined using the Brief Resilience Scale. Development of the ...

    • Translation initiation at the 5’-polyadenylated and uncapped mRNAs from the yeast viruslike elements 

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      Horáčková, Kamila

      ;

      Vopálenský, Václav

      ;

      Pospíšek, Martin

      2025

      ,

      Second Polish RNA Biology Meeting

      Linear cytoplasmic DNA plasmids pGKL1 and pGKL2, classified as virus-like elements (VLEs), have been found in the yeast Kluyveromyces lactis. VLEs encode a killer toxin and exhibit specific properties, including host ...

    • STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction 

      původní článek

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      vydavatelská verze

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      Pimková Polidarová, Markéta

      ;

      Plecitá-Hlavatá, Lydie

      ;

      Hirsch, Ivan

      ;

      Grantz Šašková, Klára

      ;

      Brázdová, Andrea

      2025

      ,

      Nature Publishing Group

      ,

      Cell Death Discovery

      ,

      11

      (1)

      The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in the cytoplasm, triggering the secretion of type I and III interferons and proinflammatory cytokines. However, ...

    • Trends of Cu and Co contaminated sediment dispersal along the Kafue River, the Zambian Copperbelt 

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      Bábek, Ondřej

      ;

      Sracek, Ondra

      ;

      Ettler, Vojtěch

      ;

      Kapusta, Jaroslav

      ;

      Kříbek, Bohdan

      ;

      Mihaljevič, Martin

      ;

      Nyambe, Imasiku

      ;

      Penížek, Vít

      ;

      Vaněk, Aleš

      ;

      Ziwa, Gabriel

      2026

      ,

      Elsevier

      ,

      Journal of Geochemical Exploration

      ,

      280

      (January)

      Rivers are important pathways for metal(loid) contamination in mining areas. The Kafue River flows through the Zambian Copperbelt with nearly a hundred-year history of Cu and Co mining. Nine cores down to 2.5 m deep were ...

    • Interactome of Proteins Encoded by Cytoplasmic Linear Plasmids of the Yeast Kluyveromyces lactis 

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      Netušilová, Kristýna

      ;

      Pospíšek, Martin

      ;

      Horáčková, Kamila

      ;

      Vopálenský, Václav

      2025

      ,

      Second Polish RNA Biology Meeting

      Yeast linear dsDNA plasmids are found in certain yeast species, including Kluyveromyces lactis, Debaryomyces robertsiae, and Pichia acaciae. Due to their structural and functional similarity mainly to poxviruses, these ...