Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 1601-1620 z 2051
-
STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
abstrakt v elektronické podobě
open access
postprint
2023
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
-
Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease
původní článek
open access
vydavatelská verze
2023
,NPJ Parkinsons Disease
,9
(1)
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative ...
-
Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder
původní článek
open access
vydavatelská verze
2023
,NPJ Parkinsons Disease
,9
(1)
REM sleep without atonia (RWA) is the hallmark of isolated REM sleep behavior disorder (iRBD) and is caused by neurodegeneration of brainstem structures. Previously, quantitative susceptibility mapping (QSM) was shown to ...
-
Kapitoly z kreativní hudební výchovy
Chapters on Creative Music Education
učebnice pro VŠ
open access
vydavatelská verze
2023
,Praha
,Univerzita Karlova, Pedagogická fakulta
Vysokoškolská učebnice Kapitoly z kreativní hudební výchovy je publikačním výstupem projektu Kreativní interakce jako zdroj motivace a inovace ve výuce vysokoškolských pedagogů a v pregraduální přípravě pedagogů HV, ...
-
Understanding the Effect of Aspartate Hydroxylase Inhibition On T Cell-Mediated Immunity Using Single-Cell RNA Sequencing
abstrakt v elektronické podobě
open access
postprint
2023
,Neuvedeno
Overexpression of aspartate β-hydroxylase (ASPH) was found in 70-90% of solid tumors but is negligible in normal tissues. Increased ASPH contributes to tumor cell proliferation, migration, and invasion but can also affect ...
-
Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
původní článek
open access
vydavatelská verze
2023
,Eurosurveillance
,28
(38)
Background: The sensitivity and specificity of selected antigen detection rapid diagnostic tests (AG-RDTs) for SARS-CoV-2 were determined in the unvaccinated population when the Delta variant was circulating. Viral loads, ...
-
Human polyomaviruses in psoriasis patients on biologic treatment
abstrakt v elektronické podobě
open access
postprint
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
-
Specific Immune Response Against SARS-CoV-2
abstrakt v elektronické podobě
open access
postprint
2023
,neuveden
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide. For effective treatment and introduction of appropriate antipandemic measures, it is necessary to understand the development ...
-
Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents
původní článek
open access
vydavatelská verze
2022
,International Journal of Molecular Sciences [online]
,23
(12)
The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key regulator of hematopoiesis, whose level is influenced by transcription through its enhancers and its post-transcriptional degradation via microRNA-155 ...
-
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
původní článek
open access
vydavatelská verze
2023
,European Journal of Medicinal Chemistry
,259
(November)
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell ...
-
The crystal structure of bis(1H-pyrazole-carboxamidine-κN,N′)bis(nitrato-κO)-copper(II), C8H12CuN10O6
původní článek
omezený přístup
vydavatelská verze
2023
,Zeitschrift für Kristallographie - New Crystal Structures
,238
(2)
C8H12CuN10O6, triclinic, P1 (no. 2), a = 7.6063(5) Å, b = 9.3072(7) Å, c = 10.8485(8) Å, alpha = 81.370(2)°, beta = 75.503(2)°, gamma = 84.756(2)° V = 733.97(9) Å(3), Z = 2, R-gt(F) = 0.0515, wR(ref)(F-2) = 0.1194, T =120(2) K.
-
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease
původní článek
open access
vydavatelská verze
2022
,Leukemia
,36
(23)
Recently, we defined "CML-like" subtype of BCR::ABL1-positive acute lymphoblastic leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here we retrospectively analyzed prognostic relevance ...
-
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
letter to the editors
omezený přístup
vydavatelská verze
2023
,Blood Advances
,7
(10)
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse ...
-
Ludwig von MISES: Socialismus: ekonomická a sociologická analýza
Ludwig von MISES: Socialism: an economical and sociological analysis
recenze
open access
vydavatelská verze
2023
,Český časopis historický
,121
(1)
Reflexe hospodářsko-historické analýzy socialistického systému. Zamyšlení nad jejím možným využitím historickou obcí v současné době.
-
Umění mezi Nietzschem a Heideggerem: vůle k moci, opojení, tvorba
Art between Nietzsche and Heidegger: Will to Power, Intoxication, Creation
původní článek
open access
vydavatelská verze
2022
,Filosofický časopis
,70
(4)
Studie sleduje proměnu filosofického pojetí umění v pozdním myšlení Friedricha Nietzscheho a v díle Martina Heideggera. Svorník mezi oběma autory je veden skrze Heideggerovy přednášky o Nietzschem z druhé poloviny 30. let. ...
-
R-Type Fonticins Produced by Pragia fontium Form Large Pores with High Conductance
původní článek
embargo
vydavatelská verze
2023
,Journal of Bacteriology
,205
(1)
Fonticins are phage tail-like bacteriocins produced by the Gram-negative bacterium Pragia fontium from the family Budviciaceae. This bacterium produces contractile-type particles that adsorb on the surface of sensitive ...
-
The role of cohorts in the understanding of the changes in fertility in Czechia since 1990
původní článek
open access
vydavatelská verze
2022
,Acta Universitatis Carolinae. Geographica
,57
(1)
This article presents a detailed analysis of the fertility changes in Czechia since 1990 using the cohort approach and contributes to the overall understanding of the fertility postponement process. Because the timing of ...
-
Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer
původní článek
open access
postprint
2023
,Molecular Oncology
,17
(10)
Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling ...
-
To screen or not to screen medical students for carriage of multidrug-resistant pathogens?
původní článek
open access
vydavatelská verze
2023
,Journal of Hospital Infection
,140
(October)
BACKGROUND: The aim of the study was to investigate the intestinal and nasal carriage of multidrug-resistant pathogens among medical students and its association with their lifestyle and demographic data. MATERIALS/METHODS: ...
-
Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation
původní článek
embargo
postprint
2023
,mSphere
,8
(4)
Wild birds including raptors can act as vectors of clinically relevant bacteria with antibiotic resistance. The aim of this study was to investigate the occurrence of antibiotic-resistant Escherichia coli in black kites ...
