Now showing items 761-780 of 1884

    • Understanding users’ responses to disclosed vs. undisclosed customer service chatbots: a mixed methods study 

      original article

      embargoed access

      published version

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      van der Goot, Margot

      ;

      Koubayová, Nathalie

      ;

      van Reijmersdal, Eva A.

      2024

      ,

      AI & Society

      ,

      39

      (6)

      Due to huge advancements in natural language processing (NLP) and machine learning, chatbots are gaining significance in the field of customer service. For users, it may be hard to distinguish whether they are communicating ...

    • Mouse PML protein isoforms and their role in innate antiviral immunity 

      abstract in e-form

      open access

      accepted version

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      Anderová, Karolína

      ;

      Rjabčenko, Boris

      ;

      Šroller, Vojtěch

      ;

      Horníková, Lenka

      ;

      Forstová, Jitka

      ;

      Huerfano Meneses, Sandra

      2024

      Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, multiprotein, membrane-less structures composed of the main scaffold PML protein and various stable or transient partner proteins. Beyond their diverse endogenous ...

    • ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines 

      abstract in e-form

      open access

      submitted version

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      Kanwal, Madiha

      ;

      Kasi, Murtaza Khan

      ;

      Šmahelová, Jana

      ;

      Olsen, Mark

      ;

      Tachezy, Ruth

      ;

      Šmahel, Michal

      2024

      ,

      Boston

      Cancer is associated with alterations in key cellular pathways, including the aspartate β-hydroxylase (ASPH) pathway. ASPH is an oncogene upregulated in various carcinomas, playing a vital role in tumor progression and ...

    • The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization 

      original article

      open access

      published version

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      Sztacho, Martin

      ;

      Červenka, Jakub

      ;

      Šalovská, Barbora

      ;

      Antiga, Ludovica

      ;

      Hoboth, Peter

      ;

      Hozák, Pavel

      2024

      ,

      Public Library of Science

      ,

      PLoS Genetics

      ,

      20

      (12)

      The RNA content is crucial for the formation of nuclear compartments, such as nuclear speckles and nucleoli. Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and ...

    • Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids 

      original article

      open access

      published version

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      Veselá, Kateřina

      ;

      Kejík, Zdeněk

      ;

      Abramenko, Nikita

      ;

      Kaplánek, Robert

      ;

      Jakubek, Milan

      ;

      Petrlova, Jitka

      2024

      ,

      Frontiers Media SA

      ,

      Frontiers in Medicine

      ,

      11

      (October)

      The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. ...

    • The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5-bisphosphate and long non-coding RNA HANR 

      original article

      open access

      published version

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      Miladinović, Ana

      ;

      Antiga, Ludovica

      ;

      Venit, Tomáš

      ;

      Bayona-Hernandez, Andrea

      ;

      Červenka, Jakub

      ;

      Labala, Rajendra Kumar

      ;

      Kolář, Michal

      ;

      Castaño, Enrique

      ;

      Sztacho, Martin

      ;

      Hozak, Pavel

      2025

      ,

      Advances in Biological Regulation

      ,

      95

      (January)

      The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to ...

    • The long-term impact of biogenic volatile organic compound emissions on urban ozone patterns over central Europe: contributions from urban and rural vegetation 

      original article

      open access

      published version

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      Liaskoni, Marina Despoina

      ;

      Huszár, Peter

      ;

      Bartík, Lukáš

      ;

      Prieto Perez, Alvaro Patricio

      ;

      Karlický, Jan

      ;

      Šindelářová, Kateřina

      2024

      ,

      Atmospheric Chemistry and Physics

      ,

      24

      (10. 12. 2024)

      The impact of biogenic emissions of hydrocarbons from vegetation on ozone, as well as on overall oxidative capacity of air, is analyzed for central European cities for a present-day period using a chemistry transport model. ...

    • HPV Infection: Present and Future of Diagnostic and Prognostic Surveys 

      abstract in e-form

      open access

      accepted version

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      Tachezy, Ruth

      2024

      High-risk types of Human Papillomavirus (HPV) are closely associated with various human malignancies. The ability to detect precancerous stages early significantly impacts patient outcomes, yet challenges remain in the ...

    • Post-COVID health policy responses to healthcare workforce capacities: a comparative analysis of health system resilience in six European countries 

      original article

      open access

      published version

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      Burau, Viola

      ;

      Buch Mejsner, Sofie

      ;

      Falkenbach, Michelle

      ;

      Fehsenfeld, Michael

      ;

      Kotherová, Zuzana

      ;

      Neri, Stefano

      ;

      Wallenburg, Iris

      ;

      Kuhlmann, Ellen

      2024

      ,

      Elsevier

      ,

      Health Policy

      ,

      139

      (January)

      A cross countries in Europe, health policy is seeking to adapt to the post-pandemic 'permacrisis', where high demands on the healthcare workforce and shortages continue and combine with climate change, and war. The success ...

    • Expert, experts et expertise pendant la crise de la COVID-19 – le cas tchèque 

      Experts, experts and expertise during the COVID-19 crisis - the Czech case

      chapter in a collective monograph

      open access

      published version

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      Kotherová, Zuzana

      ;

      Perottino, Michel

      2024

      ,

      Stockholm

      ,

      Stockholm University Press

      ,

      Comparing the place of experts during the first waves of the COVID-19 pandemic

      La crise de la COVID-19 a mis en lumière une catégorie d'experts déja bien connue en République tchèque, mais longtemps négligée et sous-financée : les épidémiologistes. Face a des défis que personne n'aurait pu prévoir, ...

    • Československá sociologická společnost při ČSAV v zrcadle svých Zpráv (1964–69) 

      The Czechoslovak Sociological Society of the Czechoslovak Academy of Sciences Reflected by its Periodical Zprávy (1964–69)

      original article

      open access

      published version

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      Nešpor, Zdeněk

      2024

      ,

      Lidé města / Urban People

      ,

      26

      (3)

      Autor analyzuje interní bullerin/časopis Československé sociologické společnosti, vycházející v letech 1965-69, a ukazuje, že ačkoli periodikum bylo velmi otevřené, tato otevřenost měla své limity, stejně jako nebylo plně ...

    • Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study 

      original article

      open access

      published version

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      Lőrincz, Balázs

      ;

      Vrablík, Michal

      ;

      Murali, Ramanathan

      ;

      Kubala Havrdová, Eva

      ;

      Horáková, Dana

      ;

      Krásenský, Jan

      ;

      Vaněčková, Manuela

      ;

      Uher, Tomáš

      2024

      ,

      Springer Verlag Italia

      ,

      Acta Neurologica Belgica

      ,

      124

      (6)

      Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods ...

    • Tidal Heating in a Subsurface Magma Ocean on Io Revisited 

      original article

      open access

      published version

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      Aygun, Burak

      ;

      Čadek, Ondřej

      2024

      ,

      Geophysical Research Letters

      ,

      51

      (10)

      We investigate the tidal dissipation in Io's hypothetical fluid magma ocean using a new approach based on the solution of the 3D Navier-Stokes equations. Our results indicate that the presence of a shallow magma ocean on ...

    • Identification of processes in Cu-ore heap leaching using Cu isotopes and leachate chemistry at Tschudi mine, northern Namibia 

      original article

      open access

      published version

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      Šráček, Ondra

      ;

      Ettler, Vojtěch

      ;

      Mihaljevič, Martin

      ;

      Kříbek, Bohdan

      ;

      Mapani, Ben

      ;

      Penížek, Vít

      ;

      Zádorová, Tereza

      ;

      Vaněk, Aleš

      2024

      ,

      Hydrometallurgy

      ,

      228

      (October)

      Copper isotopic fractionation (in δ(65)Cu) and leachate characterization were studied in the context of heap leaching at the Tschudi copper mine in northern Namibia. The leached solution is of Mg-SO4 type with high Al and ...

    • Contribution of chemical toxicity to the overall toxicity of microplastic particles: A review 

      summarizing article

      open access

      published version

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      Boháčková, Jana

      ;

      Cajthaml, Tomáš

      2024

      ,

      Science of the Total Environment

      ,

      957

      (December)

      Nanoplastics and microplastics are of growing research interest due to their persistence in the environment and potential harm to organisms through physical damage, such as abrasions or blockages, and chemical harm from ...

    • Thallium in Technosols from Allchar (North Macedonia): Isotopic and speciation insights 

      original article

      open access

      published version

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      Vaněk, Aleš

      ;

      Đorđević, Tamara

      ;

      Mihaljevič, Martin

      ;

      Vaňková, Maria

      ;

      Fizková, Karolína

      ;

      Zádorová, Tereza

      ;

      Vokurková, Petra

      ;

      Galušková, Ivana

      ;

      Penížek, Vít

      ;

      Drábek, Ondřej

      ;

      Tasev, Goran

      ;

      Serafimovski, Todor

      ;

      Boev, Ivan

      ;

      Boev, Blažo

      2024

      ,

      Environmental Pollution

      ,

      357

      (September)

      Allchar (North Macedonia) mining area is known for anomalous background Tl concentrations. In this study, we combine accurate detection of Tl stable isotope ratios with data on mineralogy/speciation and chemical extraction ...

    • Metal(loid)s in urban soil from historical municipal solid waste landfill: Geochemistry, source apportionment, bioaccessibility testing and human health risks 

      original article

      open access

      published version

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      Hiller, Edgar

      ;

      Faragó, Tomáš

      ;

      Kolesár, Martin

      ;

      Filová, Lenka

      ;

      Mihaljevič, Martin

      ;

      Jurkovič, Ľubomír

      ;

      Demko, Rastislav

      ;

      Machlica, Andrej

      ;

      Štefánek, Ján

      ;

      Vítková, Martina

      2024

      ,

      Chemosphere

      ,

      362

      (August)

      Landfills, especially those poorly managed, can negatively affect the environment and human beings through chemical contamination of soils and waters. This study investigates the soils of a historical municipal solid waste ...

    • Integrating vMAGs and Amplicon Sequencing: Bridging Gaps in Illumina-Based Assembly of Novel Large Viruses from Honey Bee Viromes 

      poster

      open access

      published version

      Gratis Apen Access Icon

      Kadlečková, Dominika

      ;

      Saláková, Martina

      ;

      Erban, Tomáš

      ;

      Tachezy, Ruth

      2024

      The study of viromes has been revolutionized by advanced bioinformatics methodologies that enable the precise identification of novel viruses. However, assembling complete genomes of large viruses is still challenging. To ...

    • Multiparametric analysis of the specific immune response against SARS-CoV-2 

      original article

      open access

      published version

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      Vránová, Lucie

      ;

      Poláková, Ingrid

      ;

      Vaníková, Šárka

      ;

      Saláková, Martina

      ;

      Musil, Jan

      ;

      Vaníčková, Marie

      ;

      Vencálek, Ondřej

      ;

      Holub, Michal

      ;

      Bohoněk, Miloš

      ;

      Řezáč, David

      ;

      Dresler, Jiří

      ;

      Tachezy, Ruth

      ;

      Šmahel, Michal

      2024

      ,

      Informa Healthcare

      ,

      Infectious Diseases

      ,

      56

      (10)

      Background: SARS-CoV-2, which causes COVID-19, has killed more than 7 million people worldwide. Understanding the development of postinfectious and postvaccination immune responses is necessary for effective treatment and ...

    • Infekce lidským papilomavirem (HPV) a gravidita 

      Human papillomavirus (HPV) infection and pregnancy

      original article

      open access

      published version

      Gratis Apen Access Icon

      Sehnal, Borek

      ;

      Halaška, Michael

      ;

      Vlk, Radovan

      ;

      Drochýtek, Vít

      ;

      Pichlík, Tomáš

      ;

      Hruda, Martin

      ;

      Robová, Helena

      ;

      Rob, Lukáš

      ;

      Tachezy, Ruth

      2024

      ,

      Epidemiologie, mikrobiologie, imunologie

      ,

      73

      (1)

      Lidský papilomavirus (HPV) je celosvětově nejběžnější sexuálně přenosnou virovou infekcí, která může vést ke vzniku benigních lézí nebo maligních nádorů. Prevalence HPV infekce je u těhotných žen dvakrát vyšší než u ...