Zobrazují se záznamy 761-780 z 1809

    • Survival in Elderly Ovarian Cancer Remains Challenging in the Nordic Countries 

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      Hemminki, Kari Jussi

      ;

      Zitrický, František

      ;

      Försti, Asta

      ;

      Hemminki, Akseli

      2024

      ,

      Cancers

      ,

      16

      (12)

      BACKGROUND: Despite treatment having improved through intensive surgical procedures and chemotherapy-and more recently, targeted therapies-ovarian cancer is the most fatal female cancer. As such, we wanted to analyze ...

    • Does virtual reality allow for a reliable assessment of reaction speed in mixed martial arts athletes? 

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      Polechonski, Jacek

      ;

      Langer, Alan

      ;

      Šťastný, Petr

      ;

      Zak, Marcin

      ;

      Zajac-Gawlak, Izabela

      ;

      Maszczyk, Adam

      2024

      ,

      Baltic Journal of Health and Physical Activity

      ,

      16

      (3)

      Introduction: The immersive virtual reality (VR) might bring a new reliable approach to diagnosing motor abilities. Therefore, the main goal of this research was to check the intertrial reliability and diagnostic possibility ...

    • Learnability of state spaces of physical systems is undecidable 

      původní článek

      embargo

      vydavatelská verze

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      Špelda, Petr

      ;

      Střítecký, Vít

      2024

      ,

      Journal of Computational Science

      ,

      83

      (December 2024)

      Despite an increasing role of machine learning in science, there is a lack of results on limits of empirical exploration aided by machine learning. In this paper, we construct one such limit by proving undecidability of ...

    • Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis 

      kazuistika

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      Hauer, Lukáš

      ;

      Moztarzadeh, Omid

      ;

      Baghalipour, Nasimeh

      ;

      Genčur, Jiří

      2024

      ,

      Psoriasis

      ,

      14

      (23 September 2024)

      The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition ...

    • Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations 

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      open access

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      Hemminki, Kari Jussi

      ;

      Niazi, Yasmeen

      ;

      Vodičková, Ludmila

      ;

      Vodička, Pavel

      ;

      Försti, Asta

      2025

      ,

      Mutagenesis

      ,

      40

      (1)

      Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...

    • Social Mobility of Elites in East-Central Europe in Historical Perspective 

      kapitola v kolektivní monografii

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      Popovici, Vlad

      ;

      Velková, Alice

      ;

      Klečacký, Martin

      2024

      ,

      Oldenbourg

      ,

      Walter de Gruyter GmbH

      ,

      Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century

      The chapter discusses the concept of the social mobility and illustrates how historians of modern-time elites in Central and Eastern Europe coneptualize and approach social mobility in conjunction with the more conventional ...

    • Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century 

      monografie

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      vydavatelská verze

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      Popovici, Vlad

      ;

      Velková, Alice

      ;

      Klečacký, Martin

      2024

      ,

      Oldenbourg

      ,

      Walter de Gruyter GmbH

      Social mobility is about climbing the societal ladder, or switching to a better, more promising or rewarding position. But how does this work for those already atop or very close to it? The studies in the book explore ...

    • Medium-run effects of COVID-19 induced distant learning on students’ academic performance 

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      Pertold-Gebicka, Barbara

      2024

      ,

      Labour Economics

      ,

      Neuveden

      (89)

      Administrative data on bachelor students for 2014/15 to 2022/23 academic years are used to analyze their performance before, during, and - what is new in the literature - after the COVID-19 pandemic. The analysis reveals ...

    • COVID angels fighting daily demons? Mental well-being of healthcare workers and religiosity 

      původní článek

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      Barili, Emilia

      ;

      Bertoli, Paola

      ;

      Grembi, Veronica

      ;

      Rattini, Veronica

      2024

      ,

      European Economic Review

      ,

      162

      (February 2024)

      Relying on a unique survey of more than 15,000 healthcare workers conducted from June to August 2020 in Italy, we show that religious priming caused participants to have a less dramatic recollection of their distressful ...

    • Enhancing the Antimycobacterial Efficacy of Pyridine-4-Carbohydrazide: Linkage to Additional Antimicrobial Agents via Oxocarboxylic Acids 

      původní článek

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      postprint

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      Pflégr, Václav

      ;

      Konečná, Klára

      ;

      Stolaříková, Jiřina

      ;

      Österreicher, Jan

      ;

      Janďourek, Ondřej

      ;

      Krátký, Martin

      2025

      ,

      Royal Society of Chemistry

      ,

      RSC Medicinal Chemistry

      ,

      16

      (2)

      This study evaluates the antimycobacterial potential of novel "mutual" bioactive amides, combining pyridine-4-carbohydrazide (isoniazid, INH) with various antimicrobial agents (sulphonamides, 4-aminosalicylic acid, ...

    • Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review 

      přehledový článek

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      Svobodová, Gabriela

      ;

      Horní, Martin

      ;

      Velecká, Eva

      ;

      Boušová, Iva

      2025

      ,

      Archives of Toxicology

      ,

      99

      (January)

      Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is ...

    • Uncovering Relationships using Bayesian Networks: A Case Study on Conspiracy Theories 

      příspěvek v recenzovaném konferenčním sborníku

      open access

      vydavatelská verze

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      Vomlel, Jiří

      ;

      Kuběna, Aleš

      ;

      Šmíd, Martin

      ;

      Weinerová, Josefína

      2024

      ,

      Nijmegen

      ,

      Proceedings of Machine Learning Research

      ,

      Probabilistic Graphical Models

      ,

      246

      Bayesian networks (BNs) represent a probabilistic model that can visualize relationships between variables. We apply various BN structure learning algorithms to a large dataset from a Czech university entrance exam. This ...

    • Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation 

      abstrakt v elektronické podobě

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      postprint

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      Pimková Polidarová, Markéta

      ;

      Brázdová, Andrea

      ;

      Plecitá, Lydie

      ;

      Hirsch, Ivan

      ;

      Grantz Šašková, Klára

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and ...

    • Do kindergartens mitigate or exacerbate socioeconomic inequalities in language exposure? The case of home-based and kindergarten-based shared book reading activities in China 

      původní článek

      open access

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      Cui, Shujing

      ;

      Greger, David

      2024

      ,

      Humanities & social sciences communications

      ,

      11

      (1)

      Shared book reading is a well-established practice for boosting children's language exposure and enhancing early development at home and in child care settings. The present study examined the socioeconomic gaps in home-based ...

    • FosA3 emerging in clinical carbapenemase-producing C. freundii 

      původní článek

      open access

      vydavatelská verze

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      Marchetti, Vittoria Mattioni

      ;

      Venturelli, Irene

      ;

      Cassetti, Tiziana

      ;

      Meschiari, Marianna

      ;

      Migliavacca, Roberta

      ;

      Bitar, Ibrahim

      2024

      ,

      Frontiers in Cellular and Infection Microbiology

      ,

      14

      (06 August 2024)

      Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...

    • Hidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A review 

      přehledový článek

      open access

      vydavatelská verze

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      Krátký, Martin

      ;

      Houngbedji, Neto-Honorius

      ;

      Vinšová, Jarmila

      2024

      ,

      Biomedicine & Pharmacotherapy

      ,

      180

      (November)

      Hydrazinecarboxamides (semicarbazides) are increasingly recognized as a versatile scaffold in developing potential antimicrobial agents. In addition to a brief overview of the synthetic methods to prepare them, this review ...

    • ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines 

      abstrakt v elektronické podobě

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      Kanwal, Madiha

      ;

      Kasi, Murtaza Khan

      ;

      Šmahelová, Jana

      ;

      Olsen, Mark

      ;

      Tachezy, Ruth

      ;

      Šmahel, Michal

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      Cancer is associated with alterations in key cellular pathways, including the aspartate ββ-hydroxylase (ASPH) pathway, an oncogene upregulated in various carcinomas that plays a crucial role in tumor progression and ...

    • The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cancer: Pilot study 

      abstrakt v elektronické podobě

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      Vojtěchová, Zuzana

      ;

      Milt, Petr

      ;

      Saláková, Martina

      ;

      Šmahelová, Jana

      ;

      Lohynská, Radka

      ;

      Lacek, Michal

      ;

      Čoček, Aleš

      ;

      Krátká, Zuzana

      ;

      Tachezy, Ruth

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study analyses the dynamics of human papillomavirus (HPV) cell cell-free DNA (cfDNA) levels ...

    • Effect of the ADAR1 signalling pathway on HCV replication 

      abstrakt v elektronické podobě

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      Kubů, Martin

      ;

      Roučová, Kristina

      ;

      Pospíšek, Martin

      ;

      Vopálenský, Václav

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      The hepatitis C virus (HCV) is a member of the Flaviviridae family, the genome of which consists of a +RNA molecule. It causes hepatitis C, which infects tens of millions of people worldwide. Although new direct direct-acting ...

    • Unveiling viral diversity through wholevirome sequencing 

      abstrakt v elektronické podobě

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      postprint

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      Saláková, Martina

      ;

      Kadlečková, Dominika

      ;

      Šimić, Ivana

      ;

      Tachezy, Ruth

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      In the dynamic landscape of viral metagenomics, our research focuses on whole-virome sequencing using the Novel enrichment technique of viromes protocol (NetoVir protocol, 1), which we have adapted to diverse starting ...