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The dynamics of telomere length in primary and metastatic colorectal cancer lesions

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Author
Kroupa, Michal
Kubeček, OndřejORCiD Profile - 0000-0003-2105-625XWoS Profile - S-3542-2016Scopus Profile - 55981498300
Tomášová, Kristýna
Hanak, Petr
Krůpová, Markéta
Červená, Klára
Šišková, Anna
Rosendorf, JáchymORCiD Profile - 0000-0003-2125-0685Scopus Profile - 57193906384
Hošek, PetrORCiD Profile - 0000-0002-9359-4770Scopus Profile - 55322449500
Vodičková, LudmilaORCiD Profile - 0000-0002-8277-539XScopus Profile - 7003998960
Vodička, PavelORCiD Profile - 0000-0003-2376-1243WoS Profile - H-3370-2014Scopus Profile - 7004841464
Liška, VáclavORCiD Profile - 0000-0002-5226-0280WoS Profile - Q-4402-2017Scopus Profile - 8705914800
John, StanislavORCiD Profile - 0000-0002-7097-5028
Vymetálková, VeronikaORCiD Profile - 0000-0001-6870-6788WoS Profile - H-3167-2014Scopus Profile - 55964160100
Petera, Jiří

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Publication date
2023
Published in
Scientific Reports
Volume / Issue
13 (1)
ISBN / ISSN
ISSN: 2045-2322
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  • 1. Faculty of Medicine
  • Faculty of Medicine in Hradec Králové
  • Faculty of Medicine in Pilsen

This publication has a published version with DOI 10.1038/s41598-023-35835-9

Abstract
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length (TL) dynamics in primary colorectal cancer (CRC) tumour tissues and corresponding liver metastases. TL was measured by multiplex monochrome real-time qPCR in paired samples of primary tumours and liver metastases along with non-cancerous reference tissues obtained from 51 patients diagnosed with metastatic CRC. Telomere shortening was observed in the majority of primary tumour tissues compared to non-cancerous mucosa (84.1%, p < 0.0001). Tumours located within the proximal colon had shorter TL than those in the rectum (p < 0.05). TL in liver metastases was not significantly different from that in primary tumours (p = 0.41). TL in metastatic tissue was shorter in the patients diagnosed with metachronous liver metastases than in those diagnosed with synchronous liver metastases (p = 0.03). The metastatic liver lesions size correlated with the TL in metastases (p < 0.05). Following the neoadjuvant treatment, the patients with rectal cancer had shortened telomeres in tumour tissue than prior to the therapy (p = 0.01). Patients with a TL ratio between tumour tissue and the adjacent non-cancerous mucosa of >= 0.387 were associated with increased overall survival (p = 0.01). This study provides insights into TL dynamics during progression of the disease. The results show TL differences in metastatic lesions and may help in clinical practice to predict the patient's prognosis.
Keywords
Humans, Colonic Neoplasms, Rectal Neoplasms, Prognosis, Liver Neoplasms, Telomere/genetics/pathology, Colorectal Neoplasms/pathology, Telomere Shortening
Permanent link
https://hdl.handle.net/20.500.14178/1963
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WOS:001022891600035
SCOPUS:2-s2.0-85161171596
PUBMED:37277368
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