Repozitář publikační činnosti UK: Recent submissions
Now showing items 81-100 of 1843
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Komunikační zdravotní gramotnost válečných uprchlíků z Ukrajiny v Česku
Communication health literacy of war refugees from Ukraine in the Czech Republic
original article
embargoed access
published version
2025
,Česká lékařská společnost J.E. Purkyně
,Časopis lékařů českých
,164
(1)
Komunikační zdravotní gramotnost je klíčová pro efektivní interakci mezi pacienty a zdravotníky. Její omezení může vést k nerovnostem v oblasti zdraví. Ukrajinští váleční uprchlíci čelí překážkám při přístupu ke zdravotní ...
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The role of glycolytic condensates in the cellular stress response during cancer progression
summarizing article
open access
published version
2025
,Elsevier
,Advances in Biological Regulation
,98
(December)
Biomolecular condensates are key organizers of the intracellular environment, which are formed through liquid-liquid phase separation. Glycolytic condensates constitute a subtype of biomolecular condensates that enable ...
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Unveiling the role of biomolecular condensates in cellular function and cancer
summarizing article
open access
published version
2025
,Elsevier
,Advances in Biological Regulation
,98
(December)
Biomolecular condensates (BMCs) are membrane-less organelles formed through liquid-liquid phase separation, primarily driven by multivalent interactions between scaffold and client molecules. These dynamic compartments ...
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Vaccinia virus mRNAs containing long 5'-poly(A)-leaders lack a canonical 5'-methylguanosine cap
original article
open access
published version
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
The vaccinia virus (VACV) is a prototypical poxvirus that was originally used to eradicate smallpox. Half a century ago, investigation into VACV mRNA substantially contributed to the fundamental discovery of the 5' mRNA ...
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Investigating NFE2L1 Activators for Targeted Protein Aggregate Clearance: A Follow-Up Study
original article
open access
published version
2025
,Royal Society of Chemistry
,RSC Medicinal Chemistry
,16
(12)
Disruption of protein homeostasis (proteostasis), whether by acute proteotoxic stress or chronic expression of mutantproteins, can lead to the accumulation of toxic protein aggregates. Such aggregation is a hallmark of ...
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Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
original article
open access
submitted version
2026
,Springer Nature
,Scientific Reports
,16
(1)
The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...
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Acute and Short-Term Hemodynamic and Echocardiography Changes During and After Left Atrial Appendage Closure
original article
open access
published version
2025
,Hindawi Limited
,Journal of Interventional Cardiology
,2025
(December)
Background: The left atrial appendage (LAA) plays an important role as a reservoir and has endocrine functions. This study aimed to assess the acute hemodynamic effects associated with LAA closure (LAAC) and ensuing ...
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Second Primary Lung Cancer Associated With Family History of Lung Cancer
original article
open access
published version
2025
,Blackwell Publishing
,Cancer Medicine
,14
(23)
BACKGROUND: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of ...
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Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
summarizing article
open access
published version
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
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Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
original article
open access
published version
2025
,Springer Nature
,Scientific Reports
,15
(1)
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, ...
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Familial risks in 317,000 prostate cancer patients in relation to metastases and survival guiding diagnostics
original article
open access
submitted version
2025
Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from ...
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Resilience českého zdravotnického systému v reakci na příchod válečných uprchlíků z Ukrajiny
The Czech Healthcare System’s Resilience in Response to the Arrival of Ukrainian War Refugees
original article
open access
published version
2025
,Sociologický ústav AV ČR v.v.i.
,Sociologický časopis / Czech Sociological Review
,61
(1)
Příchod válečných uprchlíků z Ukrajiny prověřil odolnost českého zdravotnického systému. Koncept odolnosti zdravotnického systému chápeme jako schopnost zdravotnického systému v reakci na externí krizi nadále dobře fungovat ...
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Circulation of Anaplasma phagocytophilum among invasive and native carnivore species living in sympatry in Poland
original article
open access
published version
2023
,BMC
,Parasites & Vectors
,16
(1)
Background Anaplasma phagocytophilum is characterized by a worldwide distribution and distinguished from other Anaplasmataceae by the broadest range of mammalian hosts and high genetic diversity. The role carnivores play ...
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Intratumoral MHC-I Heterogeneity: Spatiotemporal Insights into the Immune Microenvironment
abstract in e-form
open access
accepted version
2025
,ESMO Immuno-Oncology 2025 Abstract Book
The loss of major histocompatibility complex class I (MHC-I) molecules on tumor cells is a critical mechanism of resistance to cancer immunotherapy. However, the role of tumor MHC-I heterogeneity in shaping the immune ...
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From consensus to domination: inductive theorizing of the mechanisms of mini-publics deliberation on climate change
original article
restricted access
published version
2025
,Kluwer
,Climatic Change
,178
(48)
Mini-publics, including citizen panels, assemblies, and juries are increasingly being used as a way to build a bridge between elite level politics and ordinary citizens, especially on divisive and complex issues such as ...
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Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
original article
open access
published version
2023
,Springer
,Parasitology Research
,122
(10)
RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In ...
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Radiation-Induced Lymphopoenia and Treatment Outcome in Hereditary Breast Cancer Patients
original article
open access
published version
2023
,Folia Biologica
,69
(3)
Many breast cancer (BC) predisposition genes encode proteins involved in DNA damage repair (DDR). Identification of germline pathogenic va-riants (PV) in DDR genes raises the question whether their presence can influence ...
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Switch of Open-Source Automated Insulin Delivery (AID) System—AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study
original article
open access
published version
2025
,Mary Ann Liebert, Inc.
,Diabetes Technology & Therapeutics
,27
(11)
Objective: This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G ...
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Exploring the Links Between Coaches’ Education, Psychological Training and the Use of Mental Strategies in Swimming
poster
restricted access
draft
2025
This study investigated the relationships between coaches' education, psychological training and the use of mental strategies among 54 Czech swimming coaches. Using a modified TOPS 2 questionnaire, no significant differences ...
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Lysosomal Storage-Independent Fabry Disease Variants with α-Galactosidase A Misprocessing-Induced ER Stress and the Unfolded Protein Response
summarizing article
open access
published version
2025
,Nephron
,149
(10)
Background: Clinical findings in Fabry disease have classically been attributed to loss-of-function variants in the GLA gene that result in alpha-galactosidase A deficiency, intracellular accumulation of globotriaosylceramides ...
